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Pediatric Rheumatology Online Journal
Scopus
ISSN 1546-0096 · BMC · 1,930 articles in the index
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Journal Article
The emerging role of clinimetrics in pediatric rheumatology
Abstract In recent years, there has been increasing interest in the clinimetrics of pediatric rheumatic diseases. Clinimetric assessments convert the findings of clinical evaluations into standardized quantitative data, enabling more accurate monitoring of disease course and child health status and…
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Journal Article
Leveraging the PEDSnet clinical research network and electronic health record data to enhance efficiency of trial enrollment for a rare pediatric rheumatic disease
Abstract Background We evaluated the PEDSnet clinical research network for study enrollment of juvenile spondyloarthritis, a rare rheumatic disease that includes enthesitis-related arthritis (ERA) and psoriatic arthritis (PsA). Methods An electronic health record (EHR)-based typology was developed…
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Journal Article
The impact of time to diagnosis on health service use, cost, and quality of life for patients with juvenile idiopathic arthritis: a cost-utility analysis
Abstract Background Timely referral and diagnosis of Juvenile Idiopathic Arthritis (JIA) by a pediatric rheumatologist ensures early intervention to minimize long-term joint damage and disability. This study aimed to quantify the impact of delays in diagnosis on health service use, health-related…
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Journal Article
Serum bile salt-stimulated lipase levels associates with systemic inflammation and declines with effect of treatment in juvenile idiopathic arthritis
Abstract Background Juvenile idiopathic arthritis (JIA) is among the most common autoimmune diseases in children, yet its pathophysiology remains incompletely understood. Reliable biomarkers are needed to assess disease activity and guide therapy. Bile salt-stimulated lipase (BSSL), originally…
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Journal Article
Urinary ALCAM signatures define renal activity and therapeutic response in juvenile lupus nephritis
Abstract Background Lupus nephritis (LN) remains a major cause of morbidity in childhood-onset systemic lupus erythematosus (SLE). Reliable non-invasive biomarkers for early diagnosis and disease monitoring are still limited. Activated leukocyte cell adhesion molecule (ALCAM) has emerged as a…
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Journal Article
Juvenile Behçet’s disease 2014–2024: multicenter study in Colombia
Abstract Introduction Juvenile Behçet’s disease (JBD) is a rare multisystem inflammatory disorder that primarily affects the oral and genital mucosa, as well as vessels of any caliber. Between 4% and 26% of Behçet’s disease cases begin before the age of 16. JBD remains underreported, with only 55…
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Journal Article
A retrospective study of pediatric rheumatology referrals reveals large discrepancies in referring providers’ musculoskeletal exams
Abstract Background Children with inflammatory arthritis face delayed access to care, partially because of a critical provider shortage. This may be further compounded by referrals for joint pain without associated joint swelling. This study aims to investigate referring providers’ chief concern…
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Journal Article
TeMPRA: advancing continuing professional development in pediatric rheumatology in Japan
Abstract Background In the context of the global shortage of pediatric rheumatologists, mid-career specialists who can play key roles in regional education, research, and clinical practice have become increasingly important. In Japan, the Team of Mid-career Pediatric Rheumatologists Alliance…
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Journal Article
JAK inhibitors for the treatment of juvenile localized scleroderma: a case report and literature review
Abstract Background Juvenile localized scleroderma (JLS) is a chronic autoimmune and fibrosing disease that can cause significant damage and impairments. Currently, management of JLS is challenging due to the paucity of antifibrotic drugs. In patients with severe JLS, systemic glucocorticoids(GCs)…
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Journal Article
Muscle mass, strength, and sarcopenia in juvenile idiopathic arthritis: a scoping review
Abstract Background Muscle deficits are a recognized complication of juvenile idiopathic arthritis (JIA), but the long-term consequences of these alterations into adulthood are not well defined. This scoping review aims to synthesize the current evidence on both muscle mass and muscle strength…
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Journal Article
Evaluation of adalimumab tapering regimens in children and adolescents with juvenile idiopathic arthritis in remission: a simulation study
Abstract Background Adalimumab (ADM) in children with juvenile idiopathic arthritis (JIA) is usually dosed using fixed weight-based bands (label dosing: 20 mg for 9 mg/L further increased proportion with target exposure to 56–63% while keeping the proportion of patients with trough concentrations
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Journal Article
“Why did you choose that score?” – Associations between patient global assessment scores and mental health symptoms in patients with juvenile idiopathic arthritis and systemic lupus erythematosus
Abstract Background Rheumatic disease significantly alters a child’s quality of life. Rheumatologists often apply a patient global assessment score (PGA) in real time to gauge quality of life, effectiveness of treatment, and disease activity for clinical and research purposes. Previous studies…
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Journal Article
Identifying outcome measures for clinical trials in juvenile idiopathic arthritis associated uveitis for the MIWGUC proposal: a scoping review to create domains from existing outcome measures
Abstract Background and aims Chronic anterior uveitis represents the most important extra-articular manifestation of Juvenile Idiopathic Arthritis (JIA). Previous reviews have shown that outcome measures for this condition are widely heterogeneous. Therefore, our aim was to update the 2019…
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Journal Article
Anakinra use in pediatric kawasaki disease: inflammation control, coronary artery outcomes, and safety
Abstract Kawasaki disease is an acute systemic vasculitis that predominantly affects children under 5 years old and represents the leading cause of their acquired heart disease. The most serious complication involves the coronary arteries, leading to the formation of coronary artery aneurysms. The…
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Journal Article
Clinical characteristics and vascular involvement of Takayasu arteritis versus Kawasaki disease in infants and young children
Abstract Background Childhood-onset Takayasu arteritis (c-TAK) in infants and young children often presents with systemic inflammation rather than ischemic symptoms, and its clinical features overlap with intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD). To aid in early…
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Journal Article
Morning stiffness duration is associated with physician active joint count in juvenile idiopathic arthritis
Abstract Background The aim of this study was to assess whether there is an association between morning stiffness duration and the presence of active arthritis in children with Juvenile Idiopathic Arthritis (JIA). Methods A single-center retrospective observational study was conducted using data…
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Journal Article
Characteristics of JIA-associated uveitis at the age of transition
Abstract Background Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Uveitis is the most frequent extra-articular manifestation of JIA and a major cause of visual morbidity. Despite advances in immunomodulatory therapy, many patients reach adulthood with active…
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Journal Article
Investigating the utility of sarcopenia associated SARC-F and MSRA questionnaires in identifying falls and self-reported functional impairment in juvenile idiopathic arthritis
Abstract Introduction Chronic inflammation associated with ageing contributes to sarcopenia-related risk of falls and multimorbidity. The SARC-F questionnaire, based on strength, ambulation, rising from a chair, climbing stairs and falling, and MSRA (mini sarcopenia risk assessment) are validated…
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