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Journal of Immunotoxicology
Scopus
ISSN 1547-6901 · Taylor & Francis Group · 184 artikel di indeks
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Artikel Jurnal
The beneficial properties of glycomacropeptide in management of atopic dermatitis and extenuating skin aging
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by impaired skin barrier function, persistent inflammation, and increased vulnerability to environmental irritants. Chronic inflammation in AD can also contribute to premature skin aging by promoting collagen degradation…
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Associations between patient risk factors, disease severity, and inflammatory markers in community-acquired pneumonia
Community-acquired pneumonia (CAP) remains a major cause of morbidity and mortality, particularly in older adults and patients with chronic co-morbidities. Cytokine patterns and simple hematological indices may improve risk stratification beyond conventional clinical scores. In this prospective…
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Species differences influencing the safety assessment of CD3 T-cell engagers
Bispecific CD3 T-cell engagers (TCE) redirect endogenous T-cells to tumor cells and have demonstrated substantial clinical activity, but their mechanism of action also drives immune-mediated toxicities that are often underpredicted in nonhuman primate (NHP) studies. To investigate the biological…
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Seasonal variation in cytokine profiles in atopic dermatitis patients treated with dupilumab
Atopic dermatitis (AD) is primarily a TH2-driven pathology, yet seasonal factors may activate additional immune pathways. This study examined seasonal variation in plasma cytokines in adults with AD treated with dupilumab (N = 20), AD patients without systemic therapy (N = 15), and healthy controls…
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Predicting cross reactivity between the fire ant venom allergen Sol i 3 and the antigen 5 from vespid venoms based on molecular modeling computing
The fire ant Solenopsis invicta is an aggressive invasive species whose venom frequently triggers hypersensitivity reactions, including severe anaphylaxis. In endemic regions, its stings represent a significant cause of Hymenoptera-related allergy. Four venom allergens have been identified –…
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Molecular sensitization patterns in atopic dermatitis: linking food and airborne allergens using ISAC
Objective The aim of our study is to evaluate the laboratory results of sensitization to molecular components in atopic dermatitis patients and to show if there is the significant relation between the sensitization to molecular components of food allergens (regardless of the occurrence of clinical…
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Embryonic exposure to ambient concentrations of PFAS impairs the innate immune response in zebrafish and fathead minnow
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants associated with immunotoxicity; however, their effect on innate immune function in fish at ambient concentrations remains unclear. Perfluorooctane sulfonic acid (PFOS) and perfluorohexane sulfonic acid (PFHxS) are…
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Prolonged brain cytokine elevation and microgliosis following exposure to World Trade Center dust particulate matter in male spontaneously hypertensive rats
Exposure to World Trade Center (WTC) dust following the September 11, 2001 attacks has been linked to numerous negative health outcomes in First Responders, including cognitive impairment disproportionately impacting First Responders with aging. However, the mechanisms underlying neurocognitive…
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Imazalil at high plasma concentrations: implications for neutrophil immunophenotype
Neutrophil functions are tightly regulated by numerous membrane receptors, the activation of which determines the appropriate response to various endogenous and exogenous factors. Accumulating evidence indicates that environmental endocrine-disrupting chemicals (EDC) can modulate immune system…
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Artikel Jurnal
Modification of the dextran sodium sulfate model to identify agents that induce or exacerbate inflammatory bowel disease
Exposure to environmental agents has been linked to inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD) in humans. In these studies, we describe a modification of an experimental model used historically in the pharmaceutical industry to help identify…
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Micro- and nanoplastics-mediated immunometabolic reprogramming: a systemic nexus for chronic inflammation and multi-organ disease risk
Micro- and nanoplastics (MNP) are ubiquitous environmental stressors increasingly detected in human tissues and directly linked to clinical cardiovascular events. This review proposes immunometabolic reprogramming as the central nexus through which MNP drive systemic immune dysregulation and…
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Lung microbiota dysbiosis mediates PM2.5-induced pulmonary inflammation through antibiotic-reversible mechanisms
Fine particulate matter (PM2.5) exposure contributes to over 4 million premature deaths annually, yet the mechanistic role of lung microbiota in PM2.5-induced pulmonary inflammation remains poorly understood. In collaboration of 16S rRNA and single-cell RNA multi-omics analysis and in vivo/in vitro…
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Evaluating miRNAs as predictive biomarkers for drug-induced autoimmune toxicity in D-penicillamine induced autoimmune diseases animal model
Drug-induced autoimmune (DIA) toxicity represents a significant challenge in drug safety evaluation, and traditional autoantibody biomarker antinuclear antibodies (ANA) exhibits limitations in DIA assessment, highlighting the urgent need for more reliable biomarkers. This study employed…
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Evaluation of the immunotoxicity of atrazine and its chloro-metabolites: relevance for human cancer
This review was undertaken because it is known that high doses of atrazine activate the HPA axis, leading to increased corticosterone secretion, which could result in immunosuppression. The mammalian immunotoxicity of atrazine was evaluated based on in vitro and in vivo studies and the association…
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A four-week study on the toxicity of repeated intramuscular administration of plant-based BA-CoV2-0301 vaccine against SARS-CoV-2 in Sprague-Dawley rats
In December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China, leading to the global Coronavirus Disease pandemic. The rapid spread of SARS-CoV-2 highlighted the urgent need for effective vaccines. However, the high cost, cold storage…
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Artikel Jurnal
Soy allergy in patients with atopic dermatitis, sensitivity of ALEX2 Allergy Xplorer examination
The aim of the current study was to evaluate the incidence of soy allergy in patients with atopic dermatitis (AD) and to evaluate the results of specific IgE against molecular components of soy. Altogether, 100 AD patients were examined. Soy allergy was confirmed in an open exposure test (history)…
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Artikel Jurnal
Evaluating impacts of the trichloroethylene metabolite S-(1,2-dichlorovyinyl)-L-cysteine on transcriptomic responses and cytokine release in a macrophage model: implications for pregnancy outcomes
Trichloroethylene (TCE) is a volatile synthetic chemical used in various industrial processes like metal degreasing. Large amounts of TCE have been released into the environment. Exposure to TCE can occur through routes, such as inhalation for workers using TCE or ingestion of drinking water in…