118 hasil
Menampilkan 1–20 · 1,19 detik · RSS
Cell Metabolism
Scopus
ISSN 1550-4131 · Cell Press · 118 artikel di indeks
-
Artikel Jurnal
Metabolic reprogramming in liver fibrosis
Chronic liver diseases, primarily metabolic dysfunction-associated steatotic liver disease (MASLD), harmful use of alcohol, or viral hepatitis, may result in liver fibrosis, cirrhosis, and cancer. Hepatic fibrogenesis is a complex process with interactions between different resident and…
-
Artikel Jurnal Teks lengkap
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT). Indeed, specific lipids can harm CD8 + T cell (CTL) mitochondrial integrity, leading to defective antitumor responses. However, the extent to which lipids can affect the CTL functions and fate remains…
-
Artikel Jurnal
Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis
Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about a quarter of the global population. Recently, host-gut microbiota metabolic interactions have emerged as distinct mechanistic pathways implicated in the development of NAFLD. Here, we report that a group of gut…
-
Artikel Jurnal
Tryptophan metabolism in health and disease
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function…
-
Artikel Jurnal Teks lengkap
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept
With an increasing prevalence of obesity, there is a need for new therapies to improve body weight management and metabolic health. Multireceptor agonists in development may provide approaches to fulfill this unmet medical need. LY3437943 is a novel triple agonist peptide at the glucagon receptor…