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PLoS Pathogens
Scopus
ISSN 1553-7366 · Public Library of Science (PLoS) · 26,357 articles in the index
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Journal Article
A humanized IFN-γ mouse model reveals skin eschar formation, enhanced susceptibility and scrub typhus pathogenesis.
Scrub typhus, caused by Orientia tsutsugamushi (Ot) bacteria, is a serious acute febrile illness associated with significant mortality. No effective vaccine is currently available, largely due to the complex Ot strain diversity and an incomplete understanding of protective immune mechanisms. To…
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Journal Article
Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions.
Prion diseases are invariably fatal neurodegenerative diseases that occur when the prion protein misfolds into a pathogenic form. There are currently no clinical treatments or cures for prion disease. Current challenges in the development of prion therapeutics include prion strain specificity…
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Journal Article
Targeting of interaction between BB0323-BB0238 informs new paradigms in Lyme disease therapeutics.
Borrelia burgdorferi, one of the most prevalent tick-borne pathogens, can cause a complex and multisystem illness called Lyme disease, where there has been an unmet need for novel therapeutic or preventive strategies. We previously identified an essential protein-protein interaction (PPI) event in…
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Journal Article
Natural genetic variation of a single amino acid in beet necrotic yellow vein virus P31 protein modulates evasion of plant ubiquitination-mediated antiviral immunity.
Plant virus evolution frequently leads to the emergence of highly virulent strains, posing persistent threats to global crop production. However, the mechanisms by which viral evolution enables evasion of plant defense responses remain poorly understood. Here, we found that Benyvirus necrobetae…
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Journal Article
Broadly neutralizing antibody responses in a Chinese acute HIV-1 infection cohort of men who have sex with men.
Numerous broadly neutralizing antibodies (bnAbs) have been isolated from individuals with chronic HIV-1 infection, yet eliciting bnAbs through active immunization remains challenging. Investigating naturally infected patients whose plasma exhibits broadly neutralizing activity may reveal the…
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Journal Article
A BRCT domain-containing protein induced in early phagocytosis plays a crucial role in the pathogenesis of the mucoralean Rhizopus microsporus.
Mucormycosis, caused by mucoralean fungi, is among the most lethal fungal diseases, and a deeper understanding of its pathogenesis is urgently needed. Transcriptomic profiling of virulent strain (WT) and an RNAi-deficient strain (r3b2Δ) of M. lusitanicus during phagocytosis uncovered thousands of…
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Journal Article
Metarhizium anisopliae: A fungal biocontrol agent against Rhipicephalus microplus.
Also available at: DOAJ
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Journal Article
Adenovirus phagocytosis by neutrophils triggers a pro-inflammatory response.
Adenoviruses are common pathogens that have been engineered and used for medical purposes. While their recognition by innate immune cells such as macrophages and dendritic cells is well characterized, interactions with neutrophils remain poorly understood. Using cytometry,confocal and electron…
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Journal Article
Single-cell profiling of HDAC inhibitor-induced EBV lytic heterogeneity defines abortive and refractory states in B lymphoblasts.
Epstein-Barr virus (EBV) is associated with multiple malignancies including Burkitt lymphoma (BL), Hodgkin's lymphomas, nasopharyngeal carcinomas (NPC), and gastric cancers. Canonically, EBV positive tumors display latent gene expression programs that are difficult to target pharmacologically. To…
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