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Natural Product Communications
Scopus
ISSN 1555-9475 · SAGE Publishing · 7.432 artikel di indeks
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Artikel Jurnal
Research Advances on Natural Polysaccharides in the Prevention and Treatment of Alcoholic Liver Disease via the “Gut-Liver Axis”
Alcoholic liver disease (ALD) remains a globally prevalent hepatic disorder requiring safer and more effective therapeutic approaches. Natural polysaccharides, with their low toxicity and multi-target bioactive properties, show particular promise in modulating the “gut-liver axis” to mitigate ALD…
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Artikel Jurnal
Traditional Herbal Medicine Used by Iraqi Herbalists in Managing Diabetes Mellitus Type II: A Cross-Sectional Survey in the Middle Euphrates Area
Background Conventional medicine is widely used to manage diabetes, but little research has examined herbal medicines used for diabetes management in southern Iraq. Therefore, this study was designed to gather ethnobotanical data on medicinal plants used to manage diabetes in the Middle Euphrates…
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Artikel Jurnal
Astragaloside IV as a Multi-Target Neuroprotective Candidate in Ischemic Stroke and Cerebral Ischemia-Reperfusion Injury: Molecular Mechanisms and Therapeutic Perspectives
Ischemic stroke (IS) and cerebral ischemia-reperfusion injury (CIRI) involve overlapping but temporally distinct pathological processes, including oxidative stress, neuroinflammation, regulated cell death, impaired neurovascular repair, and systemic risk-factor regulation. Astragaloside IV (AS-IV)…
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Artikel Jurnal
Antimalarial Potential of the Stem Bark of (DC.) Harms: Antimalarial Activity of Hydroethanol Extract and Antiplasmodial Activity of Bioactive Constituents
Objective This study evaluated the antimalarial activity of the stem bark extract of Amphimas pterocarpoides , isolated bioactive compounds from its most active fraction, and assessed the interactions of these constituents with the Plasmodium falciparum lactate dehydrogenase (pfLDH) in silico…
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Artikel Jurnal
Health Benefits of : Insights Into Bioactive Compounds and Therapeutic Mechanisms
Elettaria cardamomum is a medicinally significant spice widely used in traditional healing practices due to its therapeutic potential. It is referred to as “Queen of Spices” which has drawn more scientific attention as scientists continue to work to confirm its health qualities using evidence-based…
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Artikel Jurnal
Self-Nanoemulsifying Systems Containing L. Extract: Development and Characterization
Background The aerial parts of Passiflora incarnata L. contain at least 1.5% total flavonoids with pharmacological activity. These compounds, acting synergistically with plant alkaloids, contribute to central nervous system (CNS) modulation and sedative effects. However, the oral delivery of…
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Artikel Jurnal
Traditional Antimalarial Medicinal Plants of Sudan: A Review of Ethnopharmacology, Antiplasmodial Extracts and Phytochemicals, Toxicology, and Future Prospects
Malaria remains a critical global health challenge and a primary cause of mortality, particularly in developing nations. The rapid emergence of antimalarial drug resistance mandates the urgent discovery of novel therapeutics, for which chemically diverse natural products remain a primary source…
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Artikel Jurnal
Polysaccharide Ameliorate Ulcerative Colitis in Mice via Regulating Sphingolipid Metabolism
Objective This study aimed to investigate the therapeutic effects of Pharbitis nil polysaccharides (PNP) on ulcerative colitis (UC) and elucidate the underlying mechanisms. Methods PNP were extracted using water extraction and alcohol precipitation. Acute UC was induced in mice by administration of…
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Artikel Jurnal
The Untapped Potential of Natural Products to Target G6PD and Disrupt the Inflammation-Cancer Axis
Glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway (PPP), plays a crucial role in cellular metabolism and maintaining oxidative homeostasis. In recent years, G6PD has gained attention as a therapeutic target in chronic inflammatory diseases…
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Artikel Jurnal
Limonoids From Cultivated Y. Nakaj. ex H. Ohba
Background The chemical constituents of Citrus × sphaerocarpa Y. Nakaj. ex H. Ohba, a cultivated Citrus species, remain insufficiently characterized despite its agricultural relevance. To expand knowledge of bioactive metabolites in Citrus plants, a methanol extract of C. × sphaerocarpa peels was…
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Artikel Jurnal
A Bibliometric Analysis of Global Trends and Research Hotspots in Medicine Food Homology
Background Medicine Food Homology (MFH) represents a fundamental concept in traditional health systems, describing natural substances with dual nutritional and therapeutic value. Despite growing global interest in MFH as a complementary health approach, a comprehensive analysis of its research…
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Artikel Jurnal
Evaluation of Glycyrrhizin on MCF 7 Breast Cancer Cells: A Molecular and Pharmacological Analysis
Introduction Breast cancer remains a leading cause of cancer-related morbidity worldwide, necessitating continued exploration of alternative therapeutic agents. Plant-based resources have been increasingly exploited because of their pharmacological usefulness. This study aimed to comparatively…
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Artikel Jurnal
Discovery of a Cryptic Secondary Metabolite, Plantazine, From the Mesophilic Plant Pathogen
Objectives Cryptic secondary metabolites from bacteria mostly remain undetected under standard cultivation conditions because their biosynthetic gene clusters are not expressed or are only weakly expressed. The present study aimed to discover cryptic secondary metabolites from Burkholderia…
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Artikel Jurnal
Short-Term Effects of a Single Dose of Black Tea on Tear Film Stability and Quality in Healthy Adults: An Interventional Study
Objective Black tea contains caffeine and polyphenols, which affect the tear film. The impact of these substances on the tear film was evaluated using the standard patient evaluation of eye dryness (SPEED) questionnaire, as well as noninvasive tear breakup time (NITBUT), tear meniscus height (TMH)…
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Artikel Jurnal
Extract Inhibits LPS-Induced Inflammatory Response in RAW264.7 Macrophage Cells
Purpose Chronic inflammation is a key contributor to the development of various metabolic and cardiovascular diseases, underscoring the importance of identifying effective anti-inflammatory agents. Natural products are gaining increasing attention as potential sources of bioactive compounds with…
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Artikel Jurnal
Editorial - Mechanisms of Action of Natural Products Against Resistant Microorganisms
Antimicrobial resistance is a major public health threat driving the search for new therapeutic options. This special collection compiles studies on natural products active against resistant microorganisms. The results show that natural compounds rarely act on a single target, instead affecting…
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Artikel Jurnal
Chemical Components and Anti-Inflammatory Activity of Branches: A Multidimensional Analysis Through Bioinformatics, Metabolomics, and In Vitro Experiments
Objective To comprehensively investigate the chemical composition and potential anti-inflammatory mechanisms of Nauclea officinalis in the management of chronic pneumonia. Methods Untargeted metabolomics was used to identify the chemical constituents of aqueous and ethanol extracts of N…
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Artikel Jurnal
Modulatory Effects of Salacinol Intake on Intestinal Putrefactive Products: A Double-Blind, Randomized, Parallel-Group Comparative Study
Objective To evaluate the effects of salacinol on stool levels of putrefactive products and intestinal function in healthy adults. Methods We conducted a double-blind, randomized, parallel-group comparative study to examine changes in stool characteristics and defecation-related symptoms associated…
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Artikel Jurnal
Discovery of Apigenin as a Multi-Target Therapeutic Drug for Osteoarthritis Complicated With Type 2 Diabetes Mellitus: Based on Network Pharmacology and in Vitro Experimental Validation
Background Osteoarthritis (OA) frequently coexists with type 2 diabetes mellitus (T2DM), and both diseases share common pathological mechanisms, particularly chronic inflammation and metabolic dysregulation. However, the shared molecular networks and potential multi-target therapeutic agents remain…
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