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Dose-Response
Scopus
ISSN 1559-3258 · SAGE Publishing · 1,411 articles in the index
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Journal Article
The Association Between Cobalt and Osteoporosis: A Cross-Sectional Study Utilizing NHANES Data
Objective This study investigates the association between blood cobalt levels and osteoporosis prevalence in the general U.S. population, addressing critical gaps in understanding low-to-moderate environmental exposure effects. Methods We analyzed 2901 adults from NHANES 2017-2020. Blood cobalt…
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Journal Article
Phantom-Based Study on Testicular Dose Protection Using Different Thicknesses of Low-Melting-Point Lead Shields in Postoperative Radiotherapy for Seminoma
Background This phantom-based study evaluated the effects of low-melting-point lead shield thickness and field-edge distance on contralateral testicular dose. Methods A 3D-CRT plan was generated de novo on CT images of the SZMC-IV anthropomorphic phantom; no patient-derived imaging or…
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Journal Article
Integrating Longitudinal Complete Blood Count Surveillance with Occupational Hp(10) Monitoring in Healthcare Workers Exposed to Low-Dose Ionizing Radiation: A Six-Year Retrospective Pilot Study
This six-year retrospective pilot evaluated the operational and analytical feasibility of linking longitudinal complete blood count (CBC) surveillance with occupational personal dose equivalent at a depth of 10 mm, Hp(10), without inferring biological safety. Among 368 screened workers, 358 had…
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Journal Article
PPARδ-Hmgcs2 Ketone Body Signaling Mediates Intestinal Stem Cells Regeneration After IR Exposure
Background Exposure to high levels of ionizing radiation or radiotherapy involving high-dose radiation can cause severe damage to healthy intestinal tissue. Intestinal stem cells (ISCs) play a crucial role in maintaining intestinal homeostasis and promoting epithelial regeneration. Peroxisome…
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Journal Article
miRNA-Targeted Herbal Compounds Against Gastric Precancerous Evolution in Chronic Atrophic Gastritis
Gastric cancer (GC) ranks third globally in cancer mortality. It develops via a well-defined pathological sequence: normal gastric mucosa progresses sequentially to superficial gastritis, chronic atrophic gastritis (CAG), intestinal metaplasia, dysplasia, and ultimately invasive carcinoma. Given…
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Journal Article
Plant-Mediated Fabrication of Iron and Zinc Oxide Nanoparticles for Anticancer Efficacy Against HT-29 and HepG2 Cells
Objectives This study aims to valorize Fagonia arabica (Dhamasa booti) herbal waste by synthesizing bioactive iron oxide (FeO) and zinc oxide (ZnO) nanoparticles for anticancer applications. Methods Aqueous extracts of F. arabica were utilized to green-synthesize FeO and ZnO NPs. The nanoparticles…
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Journal Article
Causal Association Between Gut Microbiota, Plasma Metabolites, and Prostate Cancer: Two-Step Mendelian Randomization Study
Objectives The specific role of metabolites in mediating the relationship between gut microbiota (GM) and prostate cancer (PCa) remains unclear. In this study, we utilized Mendelian randomization (MR) analyses to investigate the causal relationship between 430 GM traits, 1,400 plasma metabolites…
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Journal Article
DMSO Protects Against Radiation-Induced Ovarian Injury by Preserving Mitochondrial Function and Alleviating DNA Damage
Background and Purpose Radiation-induced ovarian injury (RIOI) compromises the clinical utility of pelvic radiotherapy and reduces fertility in young female patients. Dimethyl sulfoxide (DMSO) exhibits antioxidant property. Hearin, we aimed to explore the protective effect and underlying mechanism…
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Journal Article
A Modern Odyssey of Prevention: Integrating Nutrition and Lifestyle in Radiation Mitigation— A Narrative Review
Ionizing radiation, though indispensable in medicine, energy, and space exploration, imposes complex biological stresses that disrupt redox homeostasis, inflammation control, and genomic integrity, ultimately contributing to fibrosis, immunosuppression, and carcinogenesis. Despite advances in…
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Journal Article
Total Extract Ameliorates Cisplatin-Induced Glioma Cell Death by Regulating Ferroptosis and Inflammation
Objectives Ferroptosis is a distinct form of programmed cell death characterized by iron (Fe)-dependent oxidative stress and the accumulation of intracellular reactive oxygen species. Cisplatin (CPT), a chemotherapeutic agent, can induce ferroptosis in glioma cells and act synergistically with…
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Journal Article
Glucose Limitation Promotes Breast Cancer Cell Metastasis via Induction of LRRC15 Expression by C/EBPα
Background Cancer cells depend on a plentiful glucose supply to sustain rapid proliferation. When glucose becomes limited, they undergo adaptive changes to survive and metastasize, yet the underlying molecular mechanisms remain poorly defined. Methods LRRC15 expression was assessed in breast cancer…
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Journal Article
Shape-Restricted Detection of Natural Product Hormesis: A Re-Analysis of Complex Botanical Mixtures
Introduction Botanical supplements are consumed to improve health despite the mystery of their mechanisms. One possible effect is hormesis, defined as a beneficial and stimulatory health effect at a low dose and detrimental effect at a high dose, or vice versa. Hormesis is usually discovered by…
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Journal Article
Efficacy and Safety of Sintilimab in Combination With Anlotinib and Chemoradiotherapy as First-Line Treatment for Driver Gene-Negative Oligometastatic Non-small Cell Lung Cancer: A Real-World Cohort Study
Objective This study aimed to evaluate the efficacy and safety of sintilimab combined with anlotinib and chemoradiotherapy as first-line treatment for driver gene-negative oligometastatic non-small cell lung cancer (NSCLC). Methods This retrospective study included patients with driver…
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Journal Article
Red Blood Cell Distribution Width-To-Albumin Ratio and 90-Day Mortality in Sepsis Patients with and Without Sepsis-Induced Coagulopathy: A Retrospective Observational Study Using the MIMIC-IV Database
Background The red blood cell distribution width-to-albumin ratio (RAR) has emerged as a novel prognostic biomarker in critically ill patients. However, its association with mortality in sepsis patients, particularly in the context of sepsis-induced coagulopathy (SIC), remains unclear. Methods This…
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Journal Article
The LNT Model and ALARA in Diagnostic Imaging: A Critical Review of Scientific Evidence in the Low-Dose Range
Background The Linear No-Threshold (LNT) model and the As Low As Reasonably Achievable (ALARA) principle form the cornerstone of contemporary radiation protection. Although these frameworks were designed as conservative regulatory tools, their extrapolation to the low-dose and dose-rate (LDDR)…
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Journal Article
Carbon Ion Irradiation Suppresses Tumor Growth, Migration and Invasion in X-ray Resistant Melanoma and
Objectives To investigate whether carbon ion irradiation (CIR) can overcome the inherent radioresistance of melanoma and suppress metastasis, we evaluated its effects on B16F10 cells in vitro and in vivo . Methods B16F10 cells and C57BL/6J tumor-bearing mice were irradiated with either 4-MV X-rays…
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Journal Article
Integrating “Xiang–Hou Mutual Referencing” for Precision Pattern Differentiation in Sepsis
This commentary discusses the application of “Xiang–Hou mutual referencing” to precision syndrome differentiation in sepsis. By integrating tongue appearance, facial complexion, and pulse features with underlying pathological patterns, this framework may help characterize the dynamic transformation…
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Journal Article
DYNLRB1: A Potential Prognostic Biomarker Associated With an Immunosuppressive Microenvironment in Hepatocellular Carcinoma
Objectives To investigate the expression pattern, prognostic significance, immune relevance, and biological function of Dynein Light Chain Roadblock-Type 1 (DYNLRB1) in hepatocellular carcinoma (HCC). Methods Publicly available datasets and analytical platforms, including TCGA, GTEx, TIMER2.0…
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Journal Article
Daphnetin Attenuates Inflammatory and Apoptotic Responses Induced by High Glucose/High Free Fatty Acids and Lipopolysaccharide in an HK-2 Cell–Neutrophil Co-Culture System
Objectives The present study aimed to investigate the protective effect of daphnetin (dap) against high glucose and high free fatty acids (HGHF) and lipopolysaccharide(LPS)-induced injury in the aforementioned co-culture system under normal control conditions (normal glucose and no exogenous FFA…
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Journal Article
Research Progress on Dietary Intervention in Radiation Protection
The application of nuclear technology in energy, healthcare, and aerospace sectors is increasingly widespread, causing radiation protection to be an important topic for public health and biomedical research. Ionizing radiation causes harm by damaging cells directly or indirectly. Traditional…
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