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Лечащий Врач
ISSN 1560-5175 · Open Systems Publication · 1,507 articles in the index
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Journal Article
Large ovarian fibroma in the patient with Meigs' syndrome. Clinical case
Background. The relevance of the problem of ovarian tumors is difficult to overestimate. The incidence of benign ovarian tumors is 13.3% of all gynecological pathology. Cystadenomas account for 80% of all ovarian neoplasms. Sex cord and stromal tumors are detected in 14.9%, among them granulosa…
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Journal Article
Neonatal hyperammonemia: the evolution of views on pathogenesis, diagnosis and treatment
Background. Neonatal hyperammonemia is a condition caused by an increased content of ammonia in the blood of a newborn, both as a result of certain hereditary metabolic diseases and occurring against the background of severe pathology of the perinatal period. Neonatal hyperammonemia is defined as…
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Journal Article
Neurological complications of measles: a case of measles meningitis
Background. Measles is a pressing problem in modern medicine. At present, there is an epidemic problem with measles. The main reason for the current situation is considered to be a decrease in the coverage of the population with planned immunization. It is known that the acute period of measles is…
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Journal Article
IBS-like symptoms in inflammatory bowel diseases: clinical necessity or a terminological compromise?
Background. Despite the availability of effective therapeutic strategies aimed at inducing and maintaining remission in inflammatory bowel disease, a subset of patients continues to experience persistent gastrointestinal symptoms, including recurrent abdominal pain and alterations in stool…
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Journal Article
Type 2 diabetes mellitus and comorbid conditions: from clinical recommendations to daily practice
Background. Managing patients with type 2 diabetes mellitus with comorbidities remains a major challenge in real clinical practice. Cardiovascular disease and progressive decline in glomerular filtration rate are the leading causes of mortality in type 2 diabetes. According to international and…
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Journal Article
Features of liver damage in Niemann — Pick disease type A, A/B and B (deficiency of acidic sphingomyelinase)
Background. Acid sphingomyelinase deficiency (Niemann – Pick disease) leads to the intracellular accumulation of sphingomyelin within the mononuclear phagocyte system, including liver, spleen, lungs and bone marrow. Liver involvement represents one of the earliest and persistent visceral…
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Journal Article
Development and validation of a modified questionnaire for vector assessment of female sexual constitution
Background. The assessment of the sexual constitution is an important stage in the assessment of a woman's psychosexual development. Classical scales developed in the second half of the 20th century require revision and modification due to acceleration, changes in social norms and the emergence of…
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Journal Article
The current state of the issue of pressure ulcers: relevant pathophysiological and clinical aspects
Background. Pressure ulcers remain one of the most pressing problems in patients in a prolonged unconscious state, leading to significant medical and social consequences. The prevalence of the condition among hospitalized patients reaches 18%. At the same time, in intensive care unit patients, the…
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Journal Article
A complication of acute suppurative otitis media in the form of atypical apical cervical mastoiditis: treatment experience
Background. Acute suppurative otitis media is a common form of otitis media, involving all the compartments of the middle ear. Without appropriate management, acute suppurative otitis media extends to adjacent anatomical structures, resulting in complications such as facial nerve palsy…
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Journal Article
Iron deficiency in autoimmune gastritis
Background. IIron deficiency (nonanemic iron deficiency and iron-deficiency anemia) remains the most common condition in the general clinical practice. Iron deficiency negatively affects the prognosis of the underlying disease and reduces the quality of patient’s life. One of the most common and…
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Journal Article
Possibilities of hepatotoxicity prevention in the treatment of acute lymphoblastic leukemias in children
Background. Traditionally, supportive therapy is used to reduce severe reactions and complications during chemotherapy for acute leukemias. One of the frequent complications is the development of toxic hepatitis, which requires dose reduction or chemotherapy discontinuation until biochemical…
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Journal Article
Eponymous symptoms of skin lesions and their appendages in thyroid pathology
Background. Skin is the largest organ in the human body, closely intertwined anatomically and physiologically with all other organs and systems. The thyroid gland, as one of the largest endocrine glands, is no exception. The thyroid-skin connection is morphologically determined by the presence of…
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Journal Article
Restoring of vaginal microbiota in the bacterial vaginosis therapy: the efficacy of butyric acid and inulin. A prospective randomized study
Background. Bacterial vaginosis remains one of the most common vaginal microbiome disorders, affecting from 20% to 30% women of reproductive age worldwide. Despite standard antibiotic guidelines, recurrence rates can reach up to 50% within 12 months posttherapy. This necessitates the search for new…
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Journal Article
Features of the course of extrapulmonary tuberculosis in pregnant women (clinical case)
Background. Extrapulmonary tuberculosis represents organ and tissue damage caused by Micobacterium tuberculosis. It can occur in the absence of pulmonary tuberculosis or it can be associated with concurrent pulmonary involvement. Tuberculosis can affect any organ system, with the exception of…
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Journal Article
Lysosomal acid lipase deficiency in children: dynamics of clinical and laboratory parameters on the background of enzyme replacement therapy
Background. Lysosomal acid lipase deficiency (LALD) is a chronic, progressive disease based on a defect in the LIPA gene encoding lysosomal acid lipase, leading to impaired lipid metabolism. Currently, enzyme replacement therapy (ERT) has been developed.Objective. To evaluate the dynamics of…
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Journal Article
The role of cytological examination in the early diagnosis of non-pigmented skin melanoma: two clinical cases
Background. Cutaneous melanoma, originating from epidermal melanocytes, is one of the most aggressive tumors that metastasizes both via lymphatic and hematogenous routes. The tumor is brown or black in color, as melanoma cells continue to synthesize the pigment melanin. However, in some cases, the…
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Journal Article
Study of the cytoprotective effect of low molecular weight chitosan on a model of indomethacin gastropathy in rats
Background. Currently, gastropathy (band and punctate erosions) caused by the use of nonsteroidal anti-inflammatory drugs are the most common complications of drug therapy for acute respiratory viral infections and rheumatoid diseases. With prolonged use of nonsteroidal anti-inflammatory drugs and…
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Journal Article
Pregnancy complicated by cervical cancer: modern treatment approaches in the russian literature
Background. Cervical cancer is one of the most common forms of malignant tumors diagnosed in women of reproductive age, including during pregnancy. Due to the relative rarity of this disease in combination with pregnancy and the limited number of randomized clinical trials, the development of…
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