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Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College
ISSN 1563-3241 · KARACHI MEDICAL AND DENTAL COLLEGE · 560 artikel di indeks
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Objective Study of Surgical Outcome of Unilateral Cleft Lip Repair
Objective: The objective of study was to perform an objective assessment of postoperative aesthetic outcomes in patients undergoing unilateral cleft lip repair using Millard rotation advancement technique in patients who were operated in year 2016-2023. Methods: In this study we evaluated surgical…
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Anxiolytic and Antidepressant Potential of Euryale Ferox Seeds; A Pre-clinical Study
Objective: The current study was designed to assess the anxiolytic and anti-depressant effects of Euryale ferox seeds in mice. Methods: The study included a Control group, a Reference group (Diazepam & Fluoxetine), and two Test groups. Anxiolytic effects were evaluated using the Light/Dark Box and…
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Assessment of Internet Addiction among University Students: A Cross-Sectional Analysis of Socio-Demographic and Behavioral Factors
Objective: This study aimed to assess the prevalence of Internet addiction and examine its association with socio-demographic and behavioral factors among university students in Karachi, Pakistan. Methodology: A cross-sectional study was conducted from August 2023 to January 2024 involving 553…
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Early Childhood Caries Status and its relationship with Socio-Behavioral Factors among preschool children – A Cross-Sectional Survey
Objective: The study aims to identify the frequency of early childhood caries (ECC) and evaluate its relationship with socio-demographics, oral hygiene and dietary practices in preschool children of Karachi. Methods: This descriptive, observational, cross-sectional study was executed in two public…
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Preparation and Properties of Electrospinning Carrier Loaded with Taraxasterol-Bovine Serum Albumin-Chitosan Protein Nanoparticles
Objective: This study aimed to develop and characterize novel electrospun thin-film drug carriers. The primary innovation involved incorporating synthesized taraxasterol–bovine serum albumin–chitosan protein nanoparticles (TBC NPs) as functional reinforcing agents within a biocompatible…
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Diagnostic Accuracy of MRI for Diagnosis of Perianal FistulaTaking Operative Findings as Gold Standard AT Tertiary Care Hospital
Objective: To assess the diagnostic accuracy of MRI for detecting perianal fistulas using intraoperative findings as the reference standard, evaluate interobserver agreement in MRI interpretation, and determine the frequency of associated MRI findings. Methods: This cross-sectional study included…
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Therapeutic Potential of Herbal Medicine for Male Infertility in Pakistan from 1995 to 2025: A Systemic Review and Meta Analysis
Male-infertility is a major health issue, being a significant contributor in Pakistani couples. It is a culmination of hormonal, genetic, environmental, and lifestyle factors. Traditional therapies are expensive and unavailable to formerly resource-restrained areas. Herbal-medicines, considered…
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To Evaluate the Basic Knowledge of Emergency Health among Parents Visiting a Tertiary-level healthcare institution in Karachi, Pakistan: Cross-sectional study
Objective: To evaluate the awareness and basic knowledge of emergency health among parents of young children aged 0-8 years visiting a tertiary-level health care institute in Karachi, Pakistan. Methods: A quantitative cross-sectional survey was carried out among 211 parents from March 2025 to June…
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No association of Clotting Factor 5 gene mutation F5 A6755G (rs6027) in angiographically demonstrated coronary artery disease among the Pakistani population
Objective: To determine the correlation of genetic polymorphisms of the clotting factor V gene rs6027 among individuals with angiographically diagnosed coronary artery disease (CAD). Methods: This case-control study was conducted from December 2022 to October 2023 at the National Institute of…
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Prevalence of Malocclusion in Prehistoric, Iron Age, Medieval, and Bronze Age Populations: A Systematic Review
Malocclusion is a condition characterized by misalignment of the teeth and jaws that affects oral function and oral health. Although extensively studied in modern contexts, its patterns in historical populations remain poorly characterized. A systematic review was conducted using three databases to…
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Immune Checkpoint Inhibitor–Induced Seronegative Myasthenia-Like Syndrome Following Pembrolizumab Therapy: A Novel Adverse Drug Reaction
Immune checkpoint inhibitors (ICIs), including pembrolizumab, are increasingly associated with immune-related adverse events (irAEs), though neuromuscular complications remain rare. We report a distinctive case of pembrolizumab-induced seronegative myasthenia-like syndrome (ICI-MLS) in a…
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Analyzing The Factors Affecting Sleep Quality Among Hemodialysis Patients: A Single Center Study
Objective: To evaluate factors associated with poor sleep quality among patients receiving maintenance hemodialysis. Methods: This cross-sectional observational study was conducted from April to July 2025 at the Department of Nephrology, Tabba Kidney Institute. Adults aged 18–80 years with CKD…
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Cephalometric Assessment of Skeletal and Dental Determinants ofAnterior Open Bite in Saudi Populations
Objective: To evaluate craniofacial and dental cephalometric characteristics associated with anterior open bite and compare them with individuals exhibiting normal occlusion among the Saudi population. Methods: A retrospective cross-sectional study was conducted at the department of Orthodontics…
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Vitamin D Status in Patients with Type 2 Diabetes Mellitus: Relationship with Glycemic Control
Objective: The objective of this study is to assess the serum vit D3 levels in type 2 diabetic patients and its association with glycemic index, duration of disease and other anthropometric and metabolic profile variables in our region. Methods: It is a cross-sectional study in which 467 type 2…
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Burnout in HealthCare
Burnout is a critical concern among healthcare professionals and students. WHO defines burnout as a syndrome caused by chronic workplace stress that has not been managed, consisting of exhaustion, cynicism, checked out mental state and reduced professional efficacy. It also notes that it is an…
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Survey of Knowledge, Attitudes, and Practices Concerning RadiationExposure Among Pregnant Women and Children in Tabuk, Saudi Arabia
Objective: To assess the knowledge, attitudes, and practices of residents in Tabuk, Saudi Arabia, regarding radiation exposure during diagnostic imaging, with particular focus on the risks to pregnant women and children, who are more susceptible to the harmful effects of ionizing radiation. Methods…
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Impact of Asthma Severity and Asthma Control on Health-Related Quality of Life in Adult population
Objective: The objective of study was to compare the health -related quality of life (HRQoL) in controlled, partially controlled and poorly controlled asthmatic patients and to determine the most affected domains of HRQoL in asthma patients. Methods: This cross-sectional study was conducted in…
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Perceptual Assessment Of Velo Pharyngeal Insufficiency After Superior Based Pharyngeal Flap: Non Randomized Control Trial
Objective: To evaluate the speech outcomes following superiorly based pharyngeal flap surgery in non-syndromic cleft lip and palate patients using perceptual speech assessment. Methods: This study was conducted on 22 patients operated between 1st January 2022 and 31st December 2022 by a senior…
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From Genes to Gums: The Possible Potential Role of Vitamin D Receptor Polymorphisms in Periodontal Inflammatory Pathways
Objective: This study aimed to investigate the association between VDR gene variants (EcoRV[rs4516035], FokI [rs2228570], and Cdx2 [rs11568820]) and susceptibility to periodontitis, as well as their relationship with GCF cathelicidin levels. Methods: This is a prospective case-control study with…
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Histopathological Diagnosis of Women Presenting with Abnormaluterine Bleeding in Peri-menopausal Age
Objective: To determine the histopathological diagnosis of endometrial changes in perimenopausal women with abnormal uterine bleeding (AUB) and to assess the association with age in a secondary care setting in Karachi, Pakistan. Methods: This descriptive cross-sectional study was carried out at the…