21 results
Showing 1–20 · 0.32 seconds · RSS
Ageing Research Reviews
Scopus
ISSN 1568-1637 · Elsevier BV · 21 articles in the index
-
Journal Article Full text
Pathogenesis, diagnostics, and therapeutics for Alzheimer's disease: Breaking the memory barrier
Alzheimer's disease (AD) is the most common cause of dementia and accounts for 60-70 % of all cases. It affects millions of people worldwide. AD poses a substantial economic burden on societies and healthcare systems. AD is a progressive neurodegenerative disorder characterized by cognitive…
-
Journal Article
Trends and cross-country inequalities in the global burden of osteoarthritis, 1990–2019: A population-based study
OBJECTIVE: To evaluate the trends and cross-country inequalities of global osteoarthritis (OA) burden over the last 30 years, and further predicted its changes to 2035. METHODS: The estimates and 95 % uncertainty intervals (UIs) for incidence, prevalence, and disability-adjusted life-years (DALYs)…
-
Journal Article
Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance
Neurodegenerative disorders (NDs) are expected to pose a significant challenge for both medicine and public health in the upcoming years due to global demographic changes. NDs are mainly represented by degeneration/loss of neurons, which is primarily accountable for severe mental illness. This…
-
Journal Article Full text
Stress and telomere shortening: Insights from cellular mechanisms
Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead to disease through many pathways, and research from in vitro studies to human longitudinal studies has pointed to stress-induced telomere damage as an important pathway. However, there has not been a…
-
Journal Article Full text
Autophagy in Alzheimer’s disease pathogenesis: Therapeutic potential and future perspectives
Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the most common cause of human dementia. AD is characterized by accumulation of abnormal protein aggregates including amyloid plaques (composed of beta-amyloid (Aβ) peptides) and neurofibrillary tangles (formed by…
-
Journal Article Full text
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
-
Journal Article Full text
Mitochondria: Their relevance during oocyte ageing
The oocyte is recognised as the largest cell in mammalian species and other multicellular organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and mitochondrial architecture is different in oocytes than in somatic cells, characterised by a rounder appearance and…
-
Journal Article Full text
Targeting immune dysfunction in aging
Human aging is a multifactorial phenomenon that affects numerous organ systems and cellular processes, with the immune system being one of the most dysregulated. Immunosenescence, the gradual deterioration of the immune system, and inflammaging, a chronic inflammatory state that persists in the…
-
Journal Article Full text
Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology
Our incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive…
-
Journal Article Full text
Hypoxia and brain aging: Neurodegeneration or neuroprotection?
The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary disease. Hypoxia is pivotal to the pathogeneses of myriad neurological disorders, including Alzheimer's…
-
Journal Article Full text
Sarcopenia – Molecular mechanisms and open questions
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and generalized degenerative loss of skeletal muscle mass, quality, and strength occurring during normal aging. Sarcopenia patients are mainly suffering from the loss in muscle strength and are faced with mobility…
-
Journal Article Full text
The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to changes in the inflammatory microenvironment and may play a key role in cartilage degeneration and OA progression…