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Hereditas
Scopus
ISSN 1601-5223 · BMC · 663 articles in the index
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Journal Article
PTTG1 regulates the TGF-β/Smad pathway to promote the growth and metastasis of gastric cancer cells
Abstract Background Pituitary tumor-transforming gene 1 (PTTG1) has been implicated in multiple malignancies; however, its precise role and regulatory mechanism in gastric cancer remain unclear. This study aimed to determine how PTTG1 regulates cell proliferation, migration, and…
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Journal Article
Analysis of the biological mechanism of Gurigumu-13 in the treatment of non-alcoholic fatty liver disease based on network pharmacology
Abstract Context Gurigumu-13 (GR) was a classical Mongolian medicinal compound widely used in clinical practice for the treatment of non-alcoholic fatty liver disease (NAFLD). Objectives This study aimed to investigate the underlying mechanism by which GR exerted its therapeutic effects against…
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Journal Article
Unraveling the complexities of caffeine: metabolism, genetics, evolution, and health
Abstract Caffeine (1,3,7-trimethylxanthine) is the most widely consumed psychoactive substance globally, yet individuals differ strikingly in their physiological and health responses. These differences arise from the combined effects of genetic variation, evolutionary history, lifestyle exposures…
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Journal Article
LncRNA GAS6-AS2 regulates vascular smooth muscle cell senescence through the miR-138-5p/AKT1 axis and serves as a diagnostic and prognostic marker for atherosclerosis
Abstract Background Atherosclerosis (AS) is a leading cause of cardiovascular-related death worldwide. The role and regulatory mechanism of GAS6-AS2 in AS remain unclear. Aim To investigate the diagnostic/prognostic value of GAS6-AS2 in AS and clarify its molecular mechanism. Methods 107 AS…
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Journal Article
Multi-omics integration in deciphering non-small cell lung cancer drug resistance: current status, challenges, and future prospects
Abstract Lung cancer is the leading cause of cancer-related deaths globally. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases, and drug resistance severely undermines treatment efficacy. This review summarizes recent advances in elucidating NSCLC…
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Journal Article
Mechanistic insights into miR-4775-mediated regulation of pancreatic cancer cell invasion and migration through BRMS1L
Abstract Background and aims This study aims to investigate the effects of miR-4775 on pancreatic cancer cell (PC) invasion and migration, and to elucidate the underlying molecular mechanisms. Methods Quantitative Real-Time Reverse Transcription (RT-qPCR) was performed to analyze miR-4775 and…
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Journal Article
Unveiling cholesterol metabolism-related gene ACOX2: a multi-omics discovery of a novel biomarker in IgA nephropathy
Abstract Background The role of cholesterol metabolism in IgA nephropathy (IgAN) remains poorly understood. Methods We applied a multi-omics integrative framework to systematically identify key regulatory genes. This approach combined genome-wide association study (GWAS), summary-data-based…
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Journal Article
NSUN2 restrains gastric cancer cell apoptosis and ferroptosis by promoting the m5C modification of EPYC
Abstract Background Epiphycan (EPYC) has been confirmed to play an oncogenic role in many cancers. However, its role and mechanism in gastric cancer (GC) progression has not been explored. Methods The levels of EPYC and NOP2/Sun domain 2 (NSUN2) were detected by qRT-PCR and western blot. Cell…
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Journal Article
Mechanisms of Luoshi Neiyi prescription (LSNYP) in endometriosis: a network pharmacology and experimental study
Abstract Background Luoshi Neiyi prescription (LSNYP) is a traditional Chinese medicine that has a clinical effect on endometriosis (EMs). This study combined network pharmacology with experimental validation to explore its potential molecular mechanisms. Methods The primary components of LSNYP…
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Journal Article
OGT-mediated O-GlcNAcylation of MAGI1 exacerbates high glucose-triggered inflammation and dedifferentiation of vascular smooth muscle cells by activating the PI3K/AKT pathway
Abstract Background Vasculopathy is a vital complication of diabetes mellitus (DM), and the dysfunction of vascular smooth muscle cells (VSMCs) is a central event in its pathogenesis. O-GlcNAc transferase (OGT), the enzyme catalyzing O-GlcNAcylation, is implicated in diabetic complications, yet its…
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Journal Article
Ginsenoside Rg1 delays the senescence of adipose-derived stem cells: network pharmacology and experimental validation
Abstract Background Mesenchymal stem cell (MSC) senescence limits their therapeutic potential. Adipose-derived stem cells (ADSCs), though easily accessible, are prone to senescence under oxidative or inflammatory stress. Ginsenoside Rg1, with antioxidant and anti-inflammatory properties, may…
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Journal Article
miR-596 as a novel prognostic biomarker and tumor suppressor in breast cancer through targeting EIF5AL1
Abstract Background In terms of global incidence and mortality, breast cancer continues to surpass all other cancers affecting women. Methods To explore the role of miR-596, qRT-PCR was applied to measure its expression in tissue and cell samples from 137 enrolled subjects. The regulatory…
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Journal Article
Ferroptosis-dependent small extracellular vesicles ULK1 enhances mitophagy and suppresses breast cancer migration
Abstract Background Breast cancer progression is closely influenced by the tumor microenvironment, including macrophage polarization. Small extracellular vesicles (sEVs) derived from tumor cells serve as key mediators of intercellular communication that regulate immune responses. Ferroptosis…
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Journal Article
TRV130 inhibits colon cancer progression via suppressing the Hedgehog signaling pathway: in vitro and in vivo evidence
Abstract Background Colon cancer, characterized by high incidence and mortality, faces clinical challenges due to high recurrence rates and drug resistance. Aberrant activation of Hedgehog (Hh) signaling pathway is a key driver of colon cancer progression, making it a promising therapeutic target…
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Journal Article
Efficacy of nano-silver small intestine submucosa repair of osteochondral defect in rabbit model by the AMPK-mTOR-ULK1 pathway
Abstract Objective This study evaluated the regenerative potential of nano-silver small intestine submucosa (NSSIS) scaffolds with a 4-D porous structure for repairing osteochondral defects in rabbit knee joints. Methods NSSIS scaffolds were prepared using nanosilver, fresh pig-derived small…
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Journal Article
Linc01748 regulates the prognosis and related mechanisms of gastric cancer by targeting miR-130a-5p
Abstract Objective The purpose of this study is to investigate the expression of linc01748 in gastric cancer (GC) tissues and cell lines, and to reveal the influence and potential mechanism of linc01748 on the biological behavior of GC cells. Methods Linc01748 levels in GC were predicted through…
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Journal Article
Yishen Gushu formula exerts osteoprotective effects in OVX-Induced PMOP rats: role of ferroptosis Inhibition and iron metabolism correction
Abstract Background Postmenopausal osteoporosis (PMOP) is a common bone disease among middle-aged and elderly women. Ferroptosis, a form of programmed cell death, plays a crucial role in the regulation of bone metabolism. Yishen Gushu Formula (YSGSF), a traditional Chinese medicine (TCM) compound…
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Journal Article
Clinical relevance and mechanistic investigation of miR-1908-5p as a prognostic biomarker in colorectal cancer
Abstract Background Colorectal cancer (CRC) is characterized by a complex pathogenesis and substantial heterogeneity in prognosis. Objective This study aims to elucidate the clinical significance of miR-1908-5p in CRC, as well as its association with clinicopathological parameters and patient…
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Journal Article
Genetic polymorphism of long non-coding RNA TUG1 and susceptibility to polycystic ovary syndrome: a case-control study
Abstract Background Dysregulated expression of long non-coding RNA (lncRNA) TUG1 participates in the etiopathogenesis of polycystic ovary syndrome (PCOS). This study analyzed the genetic association of the TUG1 rs5749201 polymorphism in PCOS patients. Methods Genotype and allele distributions of…
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Journal Article
Identification and validation of energy metabolism-related genes in diabetic kidney disease through integrated bioinformatics and in vivo analysis
Abstract Background The primary renal complication of diabetes mellitus is diabetic kidney disease (DKD). The precise pathogenic mechanisms of DKD remain poorly elucidated. The aim of this study was to identify potential energy metabolism-related genes associated with DKD. Methods The GSE30529 and…