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Hematology
Scopus
ISSN 1607-8454 · Taylor & Francis Group · 759 artikel di indeks
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Artikel Jurnal
Improvement in anemia and symptoms after switching from crovalimab to iptacopan in paroxysmal nocturnal hemoglobinuria
Objectives Paroxysmal nocturnal hemoglobinuria (PNH) may develop breakthrough hemolysis (BTH) despite C5 inhibition. Although iptacopan, an oral factor B inhibitor, has demonstrated efficacy in phase 3 trials, switching from crovalimab has not been reported. We describe the first clinical case of…
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Artikel Jurnal
Apoptosis-related genes influence prognosis and immune characteristics of diffuse large B-cell lymphoma
Objectives Dysregulation of apoptosis-related genes (ARGs) may contribute to tumorigenesis and impact patient prognosis, but their specific influence on prognosis and immune characteristics in diffuse large B-cell lymphoma (DLBCL) remains unclear.Methods Gene expression profiles were collected from…
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Artikel Jurnal
Age-dependent clinical, molecular, and prognostic differences in patients with AML: a retrospective study
Objectives: This study aimed to compare clinical, and molecular features between acute myeloid leukemia (AML) patients aged
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Artikel Jurnal
Effect of autoimmune diseases on aplastic anemia: a bidirectional two-sample Mendelian randomization study
Objectives: Numerous observational research avenues have identified a possible correlation between aplastic anemia and autoimmune diseases, rooted in analogous dysfunctional immune responses. Nevertheless, causal link between autoimmune diseases and aplastic anemia remains elusive. The study aims…
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Artikel Jurnal
Proportion and characteristics of bone marrow dysplasia in advanced HIV infection
Purpose This study aims to determine the proportion of bone marrow dysplasia in advance of HIV infection.Patients and methods A cross-sectional study was conducted on advanced HIV patients, stage III and IV, with cytopenia at Hasan Sadikin General Hospital, Bandung, from January 2021 to November…
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Artikel Jurnal
XPO1 Inhibition enhances sensitivity to platinum-based chemotherapy in germinal-center B-cell-like-DLBCL cells
Purpose: Platinum-based chemotherapy is considered as salvage therapy to relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients. However, treatment failure due to drug resistance occurs in some patients, particularly those with Exportin 1 (XPO1) overexpression. This study investigates…
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Artikel Jurnal
Efficacy and mechanism of action of sovleplenib for aplastic anemia
Objective: This study aimed to investigate the therapeutic potential of sovleplenib, a selective SYK inhibitor, in aplastic anemia (AA), focusing on its effects on immune modulation and the cGAS-STING-NF-κB inflammatory axis.Methods: An immune-mediated AA mouse model was established and treated…
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Artikel Jurnal
GNE-related thrombocytopenia (Thrombocytopenia-12) in a 3-month-old from a Middle Eastern background infant: a case report
Background Congenital thrombocytopenia represents a diagnostically challenging group of disorders due to overlapping clinical presentations among various etiologies.Case Presentation A 3-month-old infant presented with severe thrombocytopenia (platelet count 6,000/μL), neutropenia, and bone marrow…
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Artikel Jurnal
Fluorescence in situ hybridization supplements to conventional karyotype for detecting aberration of chromosome 5, 7, or 17 in newly diagnosed acute myeloid leukemia
Objectives To investigate the clinical significance of Fluorescence in situ hybridization (FISH) in detecting aberration of chromosome 5, 7, or 17 in newly diagnosed acute myeloid leukemia (AML) patients.Methods We retrospectively evaluated the clinical features and outcomes of 77 adult newly…
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Artikel Jurnal
Neutrophil extracellular trap-related genes in PTCL: identification, prognosis and drug interaction prediction via bioinformatics-machine learning
Objective: This study aimed to identify neutrophil extracellular trap-related genes (NET-RGs), explore their prognostic significance, and predict drug interactions in peripheral T-cell lymphoma (PTCL).Methods: Differentially expressed NET-RGs (DE-NRGs) between PTCL and normal tissues were screened…
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Artikel Jurnal
Post-transplant cyclophosphamide as graft-versus-host disease prophylaxis for matched related donor hematopoietic stem cell transplantation in acute leukemia: a systematic review and meta-analysis
Although allogeneic hematopoietic stem cell transplantation (HSCT) offers curative potential for acute leukemia, graft-versus-host disease (GVHD) remains a major obstacle to optimal clinical outcomes. Evidence for post-transplant cyclophosphamide (PTCy) in the matched related donor (MRD) setting is…
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Artikel Jurnal
Measuring the neuropsychological consequences of thrombotic thrombocytopenic purpura: a rapid literature review
Objectives Thrombotic thrombocytopenic purpura (TTP) is a hematological disorder associated with potentially severe long-term health outcomes, including neuropsychological consequences. Guidelines recommend cognitive assessment for people with TTP, and an understanding of how the condition affects…
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Artikel Jurnal
Whole transcriptome sequencing reveals differences in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia
Objectives Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are closely related hematologic malignancies. However, the transcriptomic distinctions between them are not fully elucidated. This study aimed to identify transcriptional differences between MDS and AML using whole…
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Artikel Jurnal
The correlation between cardiac T2*MRI and B-Type natriuretic peptides in patients with transfusion-dependent anemias and systemic iron overload: a systematic review and meta-analysis
Objectives Systemic iron overload in transfusion-dependent anemias leads to progressive myocardial iron accumulation, a major cause of morbidity and mortality. This study evaluated the relationship between cardiac T2* magnetic resonance imaging (MRI) values and natriuretic peptide levels in…
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Artikel Jurnal
High body-mass index and multiple myeloma risk: insights from the global burden of disease 2021 study and identification of core target genes
Background: High Body mass index (BMI) is a well-established risk factor for various hematological malignancies. However, the relation and mechanism between high BMI and multiple myeloma remain largely unknown.Methods: This study investigates the global disease burden of multiple myeloma (MM)…
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Artikel Jurnal
Propofol and/or etomidate-induced immune thrombocytopenia: A case report
Objective: To report a case of severe immune-mediated thrombocytopenia highly suspected to be induced by propofol and/or etomidate.Clinical Features: A 62-year-old female patient developed acute, severe thrombocytopenia following two separate general anesthesia events in 2025. The first episode…
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Artikel Jurnal
Switching patients with PNH from pegcetacoplan to iptacopan: a case series
Objectives Limited published data exist on switching therapy from pegcetacoplan to iptacopan in patients with paroxysmal nocturnal hemoglobinuria (PNH).Methods Three patient cases were collected from the Mayo Clinic, Cleveland Clinic, and Levine Cancer Institute.Results Patient 1 is a 57-year-old…
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Artikel Jurnal
Chronotype and sleep duration in relation to leukaemia subtypes: a two-sample Mendelian randomization analysis
Objectives Several observational studies have suggested an association between sleep traits and leukaemia. This study aimed to determine the causal association between sleep traits and leukaemia using two-sample Mendelian Randomization (MR) analysis.Methods Publicly available databases were used to…
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Artikel Jurnal
HOTAIR promotes the progression of B-cell acute lymphoblastic leukemia by regulating the miR-326/IGF-1R axis and activating the PI3K/AKT signaling pathway
Background: B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematological malignancy. Long non-coding RNAs (lncRNAs) play important roles in hematological diseases; nevertheless, their mechanistic contributions to B-ALL are still poorly defined.Purpose: This study aimed to investigate…
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Artikel Jurnal
Secondary poor graft function after autologous stem cell transplantation in multiple myeloma: a case-based expert review and successful rescue with secondary autologous stem cell infusion
Introduction: Secondary poor graft function (PGF) after autologous hematopoietic stem cell transplantation (Auto-HSCT) for multiple myeloma (MM) is rare, often delayed in recognition, and lacks standardized salvage algorithms.Areas covered: Using a case-based expert-review format, we summarize…