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EXCLI Journal : Experimental and Clinical Sciences
Scopus
ISSN 1611-2156 · IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund · 387 artikel di indeks
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Artikel Jurnal Teks lengkap
Phyto-derived interferons: a promising frontier in antiviral therapy development
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Artikel Jurnal
MAPK/ERK Signaling in Tumorigenesis: mechanisms of growth, invasion, and angiogenesis
The significance of ERK1/2 in the process of tumorigenesis has attracted considerable interest owing to its essential role in a variety of cellular mechanisms, especially in relation to cancer initiation and progression. The Ras-Raf-MAPK signaling cascade, responsible for the activation of ERK1/2…
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The role of redox-active iron, copper, manganese, and redox-inactive zinc in toxicity, oxidative stress, and human diseases
Given the key importance played by the redox-active metals iron (Fe), copper (Cu), and manganese (Mn) in vital cellular processes, such as DNA synthesis, oxidative phosphorylation, the detoxification of reactive oxygen species (ROS), and angiogenesis, it is not surprising that their dysregulation…
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Polyphenols bind G4-Quadruplex structures and act as epigenetic modifiers with anti-cancer effects
G4-quadruplexes (G4s) are non-canonical structures of nucleic acids that develop in guanine rich regions of DNA and RNA. Due to their presence in oncogenic promoters and telomeres, G4s represent attractive targets in anti-cancer drug designs. G4s have also been the subject of recent research…
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Artikel Jurnal
Incomplete and mismatching descriptors of scanning electron microscopy (SEM) and SEM microscopes: a case study
The post-publication scrutiny of the literature occasionally reveals errors that have filtered past the scrutiny of peer reviewers and editors. Microscopes, as used in scanning electron microscopy (SEM), form an integral part of the evidence-based methodology of many biomedical studies. A 2025…
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Artikel Jurnal
Exploring the role of mTOR pathway in aging and age-related disorders
Aging is a highly intricate biochemical process. There is strong evidence suggesting that organismal aging, age-dependent diseases, and cellular senescence are related to the mammalian target of rapamycin (mTOR) signaling pathway. The signaling pathway of mTOR has become a prominent regulatory hub…
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Artikel Jurnal
Targeting metabolic vulnerabilities in breast cancer cells by combining PEDF and doxorubicin: pathway insights from GC/MS-based metabolomics
Breast cancer (BC), characterised by its diverse subtypes and molecular heterogeneity, remains a major challenge in oncology. Despite advances in chemotherapy, such as doxorubicin (Dox), limitations persist due to toxicity and drug resistance. Pigment epithelium-derived factor (PEDF) is a…
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Artikel Jurnal
Reassessing sepsis research: new clues for old players and new players for an old symptom to improve patient outcomes
Sepsis remains a global health problem that causes millions of deaths each year. A rapid and accurate diagnosis is highly desired to allow a rapid use of appropriate antibiotics. A better understanding of the associated pathophysiology has been achieved these recent years. The initial appropriate…
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Artikel Jurnal
Advancing cancer research through 3D cell culture models
Cancer is a multifactorial disease with cellular proliferative molecular networks and immune evasion properties. The well-known cancer intra- and inter-tumoral heterogeneity presents a notable limitation of the current histological and diagnostic techniques. Thus, biasing the risk of invasiveness…
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Metabolic syndrome: risk factors and molecular drug targets
Metabolic syndrome (MetS), is a non-communicable disorder caused by impaired management and storage of energy, primarily associated with unhealthy diets, sedentary lifestyles and stress. It is diagnosed when any three of the following conditions are observed, obesity (primary factor)…
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Artikel Jurnal
Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function
Polyphenols are naturally occurring compounds that can be found in plant-based foods, including fruits, vegetables, nuts, seeds, herbs, spices, and beverages, the use of which has been linked to enhanced brain health and cognitive function. These natural molecules are broadly classified into two…
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Artikel Jurnal
Dual targeting of TIGIT and VISTA in non-small-cell lung cancer immunotherapy
This study investigated the therapeutic impact of dual immune checkpoint inhibition targeting TIGIT and VISTA in non-small cell lung cancer (NSCLC). Current monotherapies have failed to produce consistent and durable responses owing to tumor heterogeneity and immune evasion. By evaluating the…
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Artikel Jurnal
Berberine pharmacological properties and therapeutic potential across cancer, digestive, metabolic, cardiovascular, and neurological diseases: an update review
Berberine (BBR) is a plant-derived alkaloid that has been traditionally used in Chinese medicine to treat diarrhea. In recent years, accumulating evidence has highlighted its broad therapeutic potential across multiple organ systems. This review systematically examines the pharmacological…