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Journal of Applied Hematology
Scopus
ISSN 1658-5127 · Wolters Kluwer Medknow Publications · 546 artikel di indeks
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Artikel Jurnal
Methemoglobinemia with an Oxygen Saturation Gap Secondary to Favism in a Newly Diagnosed Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency worldwide, with the highest prevalence in African, Asian, and Mediterranean populations, typically presenting with hemolytic anemia. On the other hand, methemoglobinemia is a potentially life-threatening…
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Red Blood Cell Metabolism in Hemoglobinopathies of Sickle Cell Disorder and Thalassemia Patients in the State of Odisha
BACKGROUND: Hemoglobinopathies are highly prevalent in Odisha, India and are associated with red blood cell (RBC) physiology through chronic hemolysis, oxidative stress, and altered energy metabolism. However, data on RBC glucose metabolism and redox status on hemoglobin variants are limited. AIMS…
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ABO and Rh Blood Groups Association with Hemoglobin and Serum Ferritin Levels in Patients with Iron Deficiency Anemia: A Cross-Sectional Study
BACKGROUND: Iron-deficiency anemia (IDA) is a common and widespread disease; but the role of blood groups ABO and Rh in affecting haemoglobin (Hb) and ferritin is unclear and has yet to be found. OBJECTIVE: To explore the relationship between ABO and Rh blood group systems and serum Hb and ferritin…
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Case Report of Severe Clostridium difficile Infection Presenting with Incidental Finding of Isolated Pulmonary Embolism
Clostridium difficile infection is a leading cause of healthcare-associated diarrhea with significant morbidity and mortality, particularly in immunocompromised and elderly patients. Due to inflammation-induced hypercoagulability and depletion of anticoagulant proteins, emerging links to…
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Prevalence of Stroke and Outcome in Relation to Risk Factors and Comorbidities in Children with Sickle Cell Disease
BACKGROUND: Stroke is a major cause of morbidity in children with sickle cell disease (SCD). We aimed to characterize clinical and demographic features, risk factors, and outcomes of pediatric SCD patients who developed stroke at a tertiary center in Saudi Arabia. METHODOLOGY: We conducted a…
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A 2-year Review of Hemoglobinopathies using High-performance Liquid Chromatography at a Single Tertiary Center in Baghdad, Iraq
BACKGROUND: Hemoglobinopathies are among the most common inherited disorders worldwide and represent a significant health burden in Iraq. High-performance liquid chromatography (HPLC) is considered a reliable and fast method for screening and diagnosis of β-thalassemia and hemoglobin variants. This…
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Predictive Utility of a Noninvasive Serum Biomarker Panel for the Diagnosis of Myelodysplastic Syndrome
BACKGROUND: Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder that predominantly affects the elderly and is characterized by bone marrow dysplasticity and cytopenia of the peripheral blood. Prompt and accurate diagnosis is essential for effective management and improvement…
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Pediatric Familial Erythrocytosis Type 2 due to a Homozygous von Hippel–Lindau Variant Presenting with Cerebral Infarcts
Familial erythrocytosis type 2 (ECYT2), also known as Chuvash polycythemia, is a rare autosomal recessive disorder caused by pathogenic variants in the von Hippel–Lindau (VHL) gene, resulting in dysregulated oxygen sensing and increased erythropoietin (EPO) production. Pediatric cases are uncommon…
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Effect of Interleukin 6 Levels on Allogeneic Stem Cell Transplantation
BACKGROUND: Interleukin (IL)-6 has been shown to be an inducer of the acute phase response and to play a role in the pathogenesis of several diseases, including graft versus host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). MATERIALS AND METHODS: The relationship…
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Revisiting the “1 g/dL Rule:” Physiological Variability in Hemoglobin Increment after Single-Unit Red Blood Cell Transfusion
BACKGROUND: Red blood cell (RBC) transfusion is commonly expected to increase hemoglobin concentration by approximately 1 g/dL/unit transfused. However, considerable variability in posttransfusion hemoglobin response is observed in routine clinical practice. Understanding the physiological factors…
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Serum Cytokeratin-18 as a Noninvasive Biomarker of Hepatocellular Injury in Patients with β-thalassemia
BACKGROUND: Chronic transfusion therapy in β-thalassemia causes progressive iron overload and oxidative hepatocellular injury. Conventional markers, such as serum ferritin and aminotransferases, are limited by their lack of specificity, highlighting the need for reliable, noninvasive biomarkers of…
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Biochemical and Statistical Predictors of Iron-deficiency Anemia among Patients with Normochromic Normocytic Anemia
BACKGROUND: The chronic illness anemia is often mild-to-moderate normocytic normochromic anemia, which changes with time to become hypochromic or microcytic. OBJECTIVE: The objective of this study was to identify the biochemical and statistical predictors of iron-deficiency anemia (IDA) among…
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Assessing Iron-deficiency Anemia among Female University Students in a Single Center
BACKGROUND: Gynecological and nutritional factors are key contributors to the development of iron deficiency anemia (IDA) in women. OBJECTIVE: This study was conducted to assess IDA among female university students in Saudi Arabia. DESIGN: Cross-sectional study. SETTING: University. PATIENTS AND…
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B-cell Maturation Antigen-directed Therapies versus Standard Regimens in Lenalidomide-refractory Relapsed or Refractory Multiple Myeloma After 1-3 Prior Lines: A Systematic Review and Network Meta-analysis of Phase 3 Trials
The therapeutic landscape for relapsed or refractory multiple myeloma (RRMM) has evolved with the introduction of B-cell maturation antigen (BCMA)-directed agents and novel triplet combinations; however, robust comparative evidence in lenalidomide-refractory patients with early relapse remains…
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Artikel Jurnal
The Correlation between Helicobacter pylori Chronic Gastritis in Adults and Anemia in GIT Center in Baghdad City
BACKGROUND: Helicobacter pylori is a widespread gastric bacterium that is linked to ulcers, chronic gastritis, and iron deficiency anemia (IDA); this paper examines its connection with anemia and determines the diagnostic value of histopathological biopsy in patients with a Baghdad GIT Center in…
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Clinical Safety and Legal Accountability of Artificial Intelligence in Hematology Diagnostic Laboratories: Risks, Failure Modes, Medicolegal Challenges, and Budgeting for Implementation
BACKGROUND: Artificial intelligence (AI) is increasingly embedded in hematology diagnostic laboratories, where it supports blood smear interpretation, flow cytometry, genomic analysis, and clinical decision support. While these tools can enhance efficiency and diagnostic accuracy, their deployment…
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Artikel Jurnal
Cancer-associated Microangiopathic Hemolytic Anemia in Lung Adenocarcinoma with Bone Marrow Metastasis
A 60-year-old woman with previous lung adenocarcinoma had bicytopenia and fragmented red blood cells (schistocytes) on a peripheral blood smear, indicating microangiopathic hemolytic anemia (MAHA). A bone marrow biopsy revealed metastatic adenocarcinoma. The identification of cancer-associated MAHA…
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Artikel Jurnal
Data Driven Prediction of EuroQol Five-dimension Five-level Outcomes in Hemophilia through Algorithmic Modeling of Quality of Life
BACKGROUND: Hemophilia is an inherited X-linked bleeding disorder, characterized by the deficiency of coagulation factor VIII (hemophilia A) or factor IX (hemophilia B), leading to recurrent bleeding, chronic joint damage, and functional impairment. Beyond clinical manifestations, hemophilia…
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Artikel Jurnal
Hematological Abnormalities among Pediatric Patients with Helicobacter pylori Infection: A Retrospective Study from Jazan, Saudi Arabia
OBJECTIVES: To describe hematological abnormalities, particularly anemia and related red blood cell indices, among pediatric patients with biopsy-confirmed Helicobacter pylori infection. METHODS: A retrospective, single-center, and cross-sectional study was conducted at King Fahad Central Hospital…