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Frontiers in Integrative Neuroscience
Scopus
ISSN 1662-5145 · Frontiers Media S.A. · 1,228 articles in the index
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Journal Article
Kiperin Mind Focus supplement mitigates chronic stress–induced neuroinflammation and molecular dysregulation and improves stress-related affective and exploratory behaviors in rats
BackgroundChronic stress is known to impair emotional regulation and adaptive behavioral responses through neuroinflammatory activation, oxidative imbalance, and dysregulation of neuroplasticity-related genes. Kiperin Mind Focus, a nootropic nutraceutical containing L-theanine, citicoline…
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Journal Article
Photobiomodulation in chronic pain: a systematic review of randomized clinical trials
IntroductionPhotobiomodulation (PBM) stands out as a promising therapeutic alternative for the management of chronic pain, but there is still controversy regarding its efficacy and safety, given the diversity of protocols and populations evaluated.ObjectivesTo critically review the available…
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Journal Article
Somato-Psychic Pathway: a universal developmental trajectory linking somatic structural–functional integrity, autonomic regulation, and the emergence of mind
The Somato-Psychic Pathway (SPP) is proposed as a universal ontogenetic developmental trajectory through which somatic structural–functional integrity and autonomic regulation shape the emergence and stability of the mind under both physiological and pathological conditions. Integrating insights…
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Journal Article
Phase-specific postural adjustments in children and adults during a challenging balance task
IntroductionAnticipatory postural adjustments (APAs) stabilize the body before voluntary movement. Although present early in life, their refinement continues into adolescence, especially during complex balance tasks.AimThis study examined developmental differences in APA control between typically…
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Journal Article
Bilateral rhythmic stimulation as a possible modulator of meningeal lymphatic flow: a regulatory T cell–centered neuroimmune hypothesis of eye movement desensitization and reprocessing
Eye Movement Desensitization and Reprocessing (EMDR) is an established therapeutic intervention for post-traumatic stress disorder and related conditions, yet its neurobiological mechanisms remain incompletely understood. While prevailing models emphasize cognitive processes such as working memory…
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Journal Article
Systematic review and meta-analysis reveal positive therapeutic effects of music in brain damage rehabilitation
Brain damage (BD) caused by stroke, traumatic brain injury (TBI), or neurodegenerative conditions often results in persistent cognitive, motor, and emotional impairments. Music-based interventions (MI) have been explored as adjunctive rehabilitation strategies; however, the evidence remains…
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Journal Article
Chronic dizziness: neuro-sensitization and psycho-sensitization
This review aims to investigate the potential mechanisms driving the transition from acute vestibular events to chronic dizziness, focusing on the roles of neural sensitization and psychological sensitization in symptom persistence. The evolution of vestibular dizziness is analyzed from the…
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Journal Article
Emergent flow theory: autonomic coherence as a gain parameter for the temporal architecture of conscious integration
Contemporary neuroscientific theories of consciousness—including Global Neuronal Workspace Theory (GNW), Integrated Information Theory (IIT), and the Predictive Processing/Free Energy Principle (PP/FEP)—have not formalized autonomic and neuromodulatory state as explicit dynamic control parameters…
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Journal Article
Fatigue relief is possible
Chronic fatigue is widely discussed across clinical and non-clinical contexts, yet its definition and measurement remain heterogeneous and debated. In this fragmented landscape, adopting an efficacy-informed perspective grounded in mitigating interventions offers a reliable pathway to delineate the…
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Journal Article
Cervico-suboccipital sensorimotor convergence as an upstream autonomic pathway in bilateral rhythmic stimulation
Rhythmic bilateral stimulation is a defining procedural feature of Eye Movement Desensitization and Reprocessing (EMDR), yet its physiological significance remains unresolved. Existing accounts have mainly emphasized rapid cognitive and attentional mechanisms during traumatic memory processing…
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Journal Article
Clinical efficacy and putative analgesic mechanism of heat-sensitive moxibustion for chronic nonspecific low back pain: a single-arm before-after study based on the brain-gut-immune axis
BackgroundChronic nonspecific low back pain (CNLBP) is one of the leading causes of disability worldwide. Growing evidence implicates brain-gut-immune axis dysregulation in the pathogenesis and perpetuation of chronic musculoskeletal pain. Heat-sensitive moxibustion (HSM), a refined form of…
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Journal Article
Interception of visible and occluded ballistic trajectories: differential contributions by areas MT/V5, V6, V6A and the vestibular premotor cortex evaluated by TMS
IntroductionSeveral cortical regions have been implicated in the control of interceptive actions, such as area MT/V5, posterior parietal areas, a vestibular area in the temporo-parietal junction (TPJ) involved in an internal representation of gravity, and premotor areas. Here, we assessed the…
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Journal Article
Persistent Afferent Bias: a mechanistic link between somatic disruption and autonomic dysregulation
Persistent Afferent Bias (PAB) represents a state-dependent alteration in sensory weighting through which Somatic Disruption influences Autonomic Regulation. While the classical concept of the facilitated spinal segment provided an early neurophysiological explanation for somatic dysfunction…
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Journal Article
Reconceptualizing bipolar disorder through an integrative biological lens: synthesis, convergence, and emerging directions
Bipolar disorder (BD) is a highly complex, chronic psychiatric illness marked by episodic disturbances of mood. While historically conceptualized as a disorder of neurotransmitter imbalance, converging evidence suggests it is better understood as a disorder of dynamic dysregulation across multiple…
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Journal Article
Hemispheric asymmetries in rodent models of neurological diseases: a systematic review
IntroductionHemispheric asymmetries are a core organizational principle of the vertebrate brain, but they are still not fully integrated into the study of preclinical models of neurological disease. Although many rodent models naturally include lateralization through unilateral interventions…
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Journal Article
Integrative perspectives on electroacupuncture modulation of vagal–cholinergic and neuro–immune–metabolic regulation in long COVID
Long COVID is increasingly recognized as a multisystem condition involving persistent inflammation, autonomic dysregulation, and metabolic disturbance. The vagus nerve–mediated cholinergic anti-inflammatory pathway (CAP) provides a biologically plausible link between neural regulation and immune…
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Journal Article
The nucleus tractus solitarii across vertebrates: developmental origins, comparative organization, and supranuclear modulation in humans
The nucleus tractus solitarii (NTS) is a highly conserved brainstem structure that has served as a principal hub for visceral sensory integration across vertebrate evolution. While the NTS has long been described as a relay for cardiovascular and respiratory reflexes, recent work increasingly…
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