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Frontiers in Endocrinology
Scopus
ISSN 1664-2392 · Frontiers Media S.A. · 21.207 artikel di indeks
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Artikel Jurnal
Implementation of guideline-recommended organ-protective therapy in people with type 2 diabetes and cardiovascular disease, heart failure, or kidney disease: real-world evidence from a German University Hospital
BackgroundOrgan-protective therapy with sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1RA) is recommended for people with type 2 diabetes (PwT2D) and cardiorenal comorbidities, yet real-world uptake remains uncertain.MethodsUsing the University…
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Artikel Jurnal
Case Report: Diabetic ketoacidosis in a patient with Klinefelter syndrome: a rare and complex presentation
BackgroundKlinefelter syndrome (KS) is a sex chromosome abnormality disease, with a reported incidence of 0.1%–0.2%, while the prevalence of KS in male infertility patients is about 3.1%. Patients with KS are prone to experience metabolic abnormalities over time, such as obesity, diabetes, and…
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Artikel Jurnal
Low HDL cholesterol is associated with elevated TNFR1 and TNFR2 levels in early diabetic kidney disease
BackgroundEarly diabetic kidney disease (DKD) remains difficult to diagnose accurately since microalbuminuria lacks sensitivity and specificity. Tumor necrosis factor receptors (TNFRs), especially TNFR1 and TNFR2, have emerged as potential markers of renal inflammation and injury. Dyslipidemia…
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Artikel Jurnal
The triglyceride-glucose index modulates the association between diabetes duration and insulin resistance in type 2 diabetes: a large cross-sectional study
BackgroundThe longitudinal impact of diabetes duration on the progression of insulin resistance (IR) in type 2 diabetes (T2DM) remains to be fully elucidated. It is also unclear whether this relationship is uniform across all patients or modified by specific metabolic factors.ObjectiveTo…
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Artikel Jurnal
Shared immune-inflammatory gene networks and drug prediction in polycystic ovary syndrome and type 2 diabetes mellitus: a bioinformatics and experimental validation study
BackgroundPolycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 diabetes mellitus (T2DM), and the risk of PCOS increases in patients with T2DM of reproductive age. The bidirectional link between PCOS and T2DM has been confirmed through experimental and epidemiological…
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Artikel Jurnal
Associations of METS-VF and BRI with risk of osteoarthritis in patients with diabetes or prediabetes: evidence from the NHANES 1999–2020
ObjectiveThis study aimed to explore the relationship between METS-VF and BRI with OA risk in DM or Pre-DM patients, evaluate their predictive value, and assess the additive effect of their combined application.MethodsWe utilized data from the NHANES 1999-2020, including adult participants…
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Artikel Jurnal
Predicting resection success in giant pituitary adenomas: morphologic determinants and a preoperative multivariate model
IntroductionGiant pituitary adenomas present significant therapeutic challenges due to their size, complex morphology, and frequent extension into critical neuroanatomical regions. Endoscopic transsphenoidal surgery (ETSS) has become the preferred first-line treatment, yet factors determining…
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Artikel Jurnal
The multifaceted role of AIF-1 in metabolic dysregulation: bridging inflammation, insulin resistance, and obesity
Allograft inflammatory factor-1 (AIF-1), a cytokine secreted by activated monocytes, macrophages, and lymphocytes, has emerged as a critical regulator of pathological processes spanning renal diseases, rheumatoid arthritis, cancer, cardiovascular disorders, neurological pathologies, and…
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Artikel Jurnal
Effect of polyethylene glycol loxenatide on weight loss in super-obese patients with type 2 diabetes: a randomized controlled trial
ObjectiveTo investigate the efficacy and safety of polyethylene glycol loxenatide (PEG-Loxe) for weight reduction and metabolic improvement in super-obese patients with type 2 diabetes mellitus (T2DM).MethodThis was a single-center, single-blind, randomized, controlled clinical trial. A total of…
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Artikel Jurnal
Skip metastases in papillary thyroid carcinoma: evidence from a multicenter European retrospective study
IntroductionPapillary thyroid carcinoma (PTC) frequently involves cervical lymph nodes. Lateral nodal involvement without central compartment disease (Skip Metastasis, SM) poses diagnostic and staging challenges. We aimed to characterize clinicopathological features of SM in a large multicenter…
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Artikel Jurnal
Association between glycated hemoglobin variability and risk of diabetic kidney disease and diabetic retinopathy in diabetic patients: a systematic review and meta-analysis
ObjectiveTo provide a scientific basis for the early prevention of diabetic kidney disease and diabetic retinopathy progression in diabetic patients by systematically evaluating the relationship between glycated hemoglobin (HbA1c) variability and diabetic kidney disease and diabetic retinopathy in…
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Artikel Jurnal
Targeting the gut microbiome for type 2 diabetes management: a scoping review of systematic reviews and meta-analyses
BackgroundThe Gut Microbiome (GM) is now a novel target for the treatment of Type 2 Diabetes Mellitus (T2DM), and several systematic reviews and Meta-analyses have provided evidence on the efficacy and safety of modulating GM in T2DM, but this evidence has not been consolidated.ObjectiveThe purpose…
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Artikel Jurnal
Optimizing mature oocyte yield in IVF: clinical comparison of r-hFSH+r-hLH and HMG in women with a stimulation dosage of at least 300 IU of gonadotropins
ObjectiveTo study the impact of luteinizing hormone (LH) in stimulation medication on the mature oocyte yield obtained in in women receiving ovarian stimulation (OS) with a dosage of at least 300 IU gonadotropins.DesignRetrospective cohort study (01/2016-05/2024).SettingTertiary assisted…
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Artikel Jurnal
Construction and verification of a risk prediction model for diabetic retinopathy patients complicated with deep capillary plexus diabetic macular ischaemia
BackgroundTo explore the risk factors for deep capillary plexus diabetic macular ischaemia (DCP-DMI) in patients with diabetic retinopathy and to establish and validate a risk prediction model.MethodsDiabetic retinopathy patients who visited the ophthalmology department of Suining Central Hospital…
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Artikel Jurnal
Identification of maturity-onset diabetes of the young through targeted next-generation sequencing in Thai patients with atypical diabetes in real-world practice
IntroductionMaturity-onset diabetes of the young (MODY) is often misdiagnosed as either autoimmune type 1 diabetes (T1D) or polygenic type 2 diabetes (T2D), resulting in missed diagnosis and inappropriate treatment. Differentiating MODY from T2D is challenging in Asians with low body mass index…
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Artikel Jurnal
[68Ga]Ga-DOTATATE PET/CT and PET/MR enhances the detection of pituitary ACTH-secreting adenomas in cushing’s disease
IntroductionThis study aimed to evaluate the diagnostic performance of [68Ga]Ga-DOTATATE PET/CT or PET/MR in comparison to dynamic MR (dMR) in locating ACTH-secreting pituitary adenomas in Cushing's disease (CD). The utility of PET and MR semi-quantitative parameters was additionally explored as…
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