55.770 hasil
Menampilkan 1–20 · 0,60 detik · RSS
Frontiers in Immunology
Scopus
ISSN 1664-3224 · Frontiers Media S.A. · 55.770 artikel di indeks
-
Artikel Jurnal
Detection of RBC-bound antibodies using flow cytometry and their correlation with HLA polymorphism
BackgroundThe immune response in elderly individuals is influenced by genetic factors, particularly polymorphisms in major histocompatibility complex (MHC), such as human leukocyte antigen (HLA). Age-related changes in immune function, referred to as immunosenescence, can lead to the formation of…
-
Artikel Jurnal
De novo and quiescent cGVHD are distinguishable in a prognostic biomarker panel
Chronic graft-versus-host disease (cGVHD) remains the most significant long-term complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), despite increasing insights into its pathogenesis. The development of reliable prognostic biomarkers is essential for identifying…
-
Artikel Jurnal
Macrophage polarization in acute myocardial infarction: multidimensional regulation and emerging therapeutic opportunities
Macrophage polarization is a central determinant of the inflammatory response and tissue repair following acute myocardial infarction (AMI). The dynamic transition from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype is critical for limiting myocardial injury and promoting…
-
Artikel Jurnal
Distribution of granzyme-expressing NK cells in tuberculosis reflects subset and compartment-specific remodeling
IntroductionNatural killer (NK) cells contribute to immunity against Mycobacterium tuberculosis (Mtb), yet their granzyme expression and subset distribution in TB remain poorly defined.MethodsNK cell subsets and the expression of granzymes (GZMA, GZMB, and GZMK) and CCR5 were analyzed by…
-
Artikel Jurnal
Large-scale proteome profiling identifies circulating biomarkers for disease activity and organ involvement in ANCA-associated vasculitides
ObjectiveAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are chronic, relapsing inflammatory diseases, yet reliable biomarkers for detecting relapse and organ involvement remain limited. This study aimed to identify plasma protein biomarkers that distinguish active disease…
-
Artikel Jurnal
A self-perpetuating neuron-intrinsic GSDMD–mtDNA–AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury
IntroductionTraumatic brain injury (TBI) is a leading cause of mortality and long-term disability worldwide, producing acute neurological deficits and lasting cognitive impairment. Post-injury neuroinflammation is a principal driver of secondary damage and contributes substantially to TBI-induced…
-
Artikel Jurnal
Pathological neutrophil extracellular traps hinder postoperative anal fistula wound healing and are attenuated by Zuoqing granule via suppression of the Nox4 pathway
BackgroundThe impaired healing of postoperative anal fistula wounds often complicated by a contaminated environment and persistent inflammation. The key pathological immune events that sustain this chronic inflammatory milieu remain largely unknown. We hypothesized that dysregulated neutrophil…
-
Artikel Jurnal
Single-cell transcriptomics of Pacific white shrimp (Litopenaeus vannamei) hepatopancreas reveal immune and metabolic responses to AHPND-causing Vibrio parahaemolyticus
BackgroundThe shrimp aquaculture industry is severely impacted by acute hepatopancreatic necrosis disease (AHPND) caused by the bacterium Vibrio parahaemolyticus. The hepatopancreas is a multi-functional organ with roles in digestion, immunity, molting and reproduction. The mechanism by which the…
-
Artikel Jurnal
Safety and efficacy of B-cell therapy in older people with multiple sclerosis
BackgroundThe MS population is aging, with nearly one-third now over 55 years. This group is underrepresented in trials and less often prescribed high-efficacy therapy (HET). Although phase III studies of ocrelizumab and ofatumumab confirmed efficacy in younger patients, the risk–benefit profile in…
-
Artikel Jurnal
Kidney transplantation beyond immunosuppression: shifting the focus from graft survival to patient health
Kidney transplantation has traditionally focused on maximizing graft survival, with immunosuppressive therapy as the cornerstone of care. However, long-term patient health requires a broader perspective that addresses the prevention and management of post-transplant complications. This review…
-
Artikel Jurnal
Integrated analysis of single-cell and bulk transcriptomes reveals the prognostic value of polyamine metabolism biomarkers and immune microenvironment features in gastric cancer
BackgroundGastric cancer (GC) remains a lethal malignancy with limited prognostic biomarkers. Dysregulated polyamine metabolism promotes tumor progression and immune evasion, yet its clinical implications in GC are poorly characterized.MethodsWe conducted an integrative analysis using bulk RNA-seq…
-
Artikel Jurnal
The promise of IL-1β modulation in NSCLC clinical context
Emerging preclinical evidence challenges the long-standing assumption that Interleukin-1β (IL-1β) uniformly promotes non–small cell lung cancer (NSCLC). We show that, in the context of chemo-immunotherapy, IL-1β enhances anti-tumor immunity by inducing tumor-cell CXCL10 expression and recruiting…
-
Artikel Jurnal
Role of PBAF and Mediator kinase module in the RELA-dependent activation of CXCL1–3 inflammation genes of the NF-kB pathway
IntroductionThe transcription of inflammatory genes is rapidly induced by extracellular stimuli through coordinated actions of transcription factors and large coactivator complexes. However, the mechanistic interplay between specific chromatin remodelers and kinase modules in driving the…
-
Artikel Jurnal
Aberrant signaling in tonsillar B cells producing pathogenic O-glycoforms of IgA1 in IgA nephropathy
IgA nephropathy (IgAN) is a mesangioproliferative glomerulonephritis characterized by IgA1-containing immune-complex deposits wherein IgA1 is enriched for galactose-deficient IgA1 (Gd-IgA1) glycoforms. IgAN pathogenesis involves mucosal immune system, as IgAN onset and activity are associated with…
-
Artikel Jurnal
The dual roles of ferroptosis in digestive tract tumors: mechanisms, microenvironment regulation, and therapeutic integration with emphasis on immune interactions
Malignant tumors of the digestive tract are a major global health burden, characterized by high incidence and mortality rates, limited treatment options for advanced patients, and poor prognosis. Ferroptosis is an iron-regulated form of cell death driven by lipid peroxide (LPO) accumulation, and it…
-
Artikel Jurnal
Mechanistic investigation into the differences in growth performance and resistance to spring viremia of carp virus in common carp
IntroductionSpring viremia of carp virus (SVCV) is a highly infectious pathogen threatening common carp (Cyprinus carpio). Hence, implementing protective measures is crucial to safeguard aquatic species and minimize economic impacts, including pharmaceuticals, vaccines, and breeding of resistant…
-
Artikel Jurnal
Immunomodulatory properties of human dental pulp stromal cells: the role of IL-6/JAK/STAT3 pathway and PD-L1
IntroductionHuman Dental Pulp Stromal Cells (hDPSCs) of neural-ectodermal origin hold immunomodulatory properties which make them a source for MSC-based therapies for the treatment of autoimmune diseases.MethodsIn this study hDPSCs were exposed to inflammatory conditions mimicked by co-culture with…
-
Artikel Jurnal
Meningeal lymphatic vessel dysfunction exacerbates brain injury in CVST mice via endoplasmic reticulum and oxidative stress pathways
ObjectiveMeningeal lymphatic vessels (mLVs) play a significant role in neurological homeostasis and disease. However, their contribution to brain injury following cerebral venous sinus thrombosis (CVST) remains unknown. This study investigated whether mLV dysfunction influences the pathological…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.