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Linchuang shenzangbing zazhi
ISSN 1671-2390 · Editorial Department of Journal of Clinical Nephrology · 2,758 articles in the index
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Journal Article
Advances in risk‑prediction models for IgA nephropathy
IgA nephropathy （IgAN） is a common glomerular disease in China with heterogeneous clinical presentations and pathological changes. Disease course and outcomes vary widely between individuals. Renal biopsy remains essential for diagnosis， and the presence of dominant or codominant IgA deposition on…
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Journal Article
A study of the atherogenic index of plasma and risk of incident kidney disease in middle‑aged and elderly patients with diabetes mellitus
ObjectiveTo investigate whether a higher atherogenic index of plasma （AIP） is associated with an increased risk of incident kidney disease in middle‑aged and elderly patients with diabetes mellitus.MethodsWe analyzed 2，119 middle‑aged and elderly diabetic participants who completed three waves…
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Journal Article
Comparison of CD19+ B‑cell depletion and relapse rates in children with frequently relapsing or steroid‑dependent nephrotic syndrome treated with different rituximab regimens
ObjectiveTo investigate the relationship between the number of rituximab （RTX） infusions， the duration of CD19+ B‑cell depletion， and relapse rates in children with frequently relapsing or steroid‑dependent nephrotic syndrome （FRNS/SDNS）， and to analyze the association between the time to first…
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Journal Article
Advances in research on endothelin‑1 in acute kidney injury
Acute kidney injury （AKI） is a clinical syndrome characterized by a rapid decline in renal function caused by various etiologies， and it is associated with high morbidity and mortality. Despite continuous improvements in renal replacement therapy， the rate of progression from AKI to chronic kidney…
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Journal Article
Advances in the study of immune cell function in patients with chronic kidney disease
Chronic kidney disease （CKD） is a common chronic condition in China with complex etiologies and pathogenic mechanisms. Immune system dysregulation is an important contributor to the onset and progression of renal disease. Immune responses mediated by diverse immune cell populations form a…
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Journal Article
Clinical value of the prognostic nutritional index combined with the neutrophil-to-lymphocyte ratio for assessing frailty in maintenance hemodialysis patients and improvement of a predictive model
ObjectiveTo investigate the associations of the prognostic nutritional index （PNI） and the neutrophil-to-lymphocyte ratio （NLR） with frailty in maintenance hemodialysis （MHD） patients， and to develop and validate a predictive model.MethodsThis retrospective study enrolled 400 patients receiving…
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Journal Article
Construction of a peritoneal dialysis catheter‑associated peritonitis model and optimization of peritoneal tissue sampling methods
ObjectiveCurrent animal models of peritoneal dialysis （PD） catheter‑associated peritonitis face issues including heterogeneity of catheter materials， complicated assembly， leakage， and occlusion， and there is a lack of a reliable method for harvesting peritoneal tissue. This study aimed to develop…
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Journal Article
Clinical characteristics and risk factors of infection in patients with ANCA‑associated vasculitis
ObjectiveTo investigate the distribution of pathogens and risk factors for infection in patients with antineutrophil cytoplasmic antibody⁃associated vasculitis （AAV）.MethodsWe retrospectively reviewed 135 AAV inpatients treated at Zigong First People's Hospital between January 2015 and December…
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Journal Article
C-reactive protein-albumin-lymphocyte index predicts prognosis in IgA nephropathy： a retrospective cohort study
ObjectiveTo evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte （CALLY） index in patients with IgA nephropathy （IgAN）.MethodsWe retrospectively enrolled 266 patients with biopsy-proven IgAN treated at the South Campus of the First Affiliated Hospital of USTC （Anhui Provincial…
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Journal Article
Mendelian randomization study of the causal relationship between Sjögren's syndrome and glomerulonephritis
ObjectiveTo investigate the causal relationship between Sjögren's syndrome （SS） and glomerulonephritis （GN） using Mendelian randomization （MR）.MethodsGenome‑wide association study （GWAS） summary data for relevant diseases were obtained from public databases. Single nucleotide polymorphisms （SNPs）…
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Journal Article
Efficacy of low‑， medium‑， and standard‑dose rituximab in the treatment of membranous nephropathy
ObjectiveTo evaluate the efficacy of low， medium， and standard doses of rituximab in patients with membranous nephropathy （MN）.MethodsThis retrospective study included 100 MN patients treated with rituximab in the Department of Nephrology at Huaihai Hospital Affiliated to Xuzhou Medical University…
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Journal Article
Podocyte hypertrophy in IgA nephropathy： associations with clinical features and prognosis
ObjectiveTo investigate the clinicopathological features of podocyte hypertrophy （PH） in IgA nephropathy （IgAN） patients with S1 lesions （≥1 glomerulus with segmental sclerosis or adhesion） and to assess the independent and combined predictive value of PH and the International IgAN Risk Prediction…
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Journal Article
Screening and Identification of Early Pathogenic Genes of diabetes Kidney Disease Based on Multiomics
ObjectiveBased on bioinformatics， this study explored the related genes and pathways of diabetes kidney disease （DKD） from a multi group perspective， aiming to enrich the research of DKD related genes and potential pathogenesis， dig out biomarkers that are helpful to the diagnosis of DKD， and…
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Journal Article
Mindin protein regulates macrophage M1 polarization and mediates the development of acute kidney injury
ObjectiveTo investigate the role and mechanism of Mindin protein in acute kidney injury （AKI）.MethodsFive AKI-related datasets from the Gene Expression Omnibus （GEO） database （GSE30718， GSE139061， GSE227970， GSE248078， and GSE61739） were jointly analyzed to identify differentially expressed genes…
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Journal Article
Screening status and determinants of chronic kidney disease among high-risk individuals in a community in Chengdu
ObjectiveTo assess the screening status of high-risk individuals for chronic kidney disease （CKD） in a community in Chengdu and to identify the main factors associated with incident CKD， thereby providing evidence for community-based CKD prevention and control strategies.MethodsClinical data were…
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Journal Article
Recent advances in the genetics of anti-neutrophil cytoplasmic antibody-associated vasculitis
Anti-neutrophil cytoplasmic antibody （ANCA）-associated vasculitis （AAV） is a common systemic necrotizing small-vessel vasculitis， but its pathogenesis has not yet been fully elucidated. At present， genetic factors are considered to play an important role in risk prediction and disease…
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Journal Article
Advances in the diagnosis and treatment of peritoneal dialysis-associated peritonitis
Peritoneal dialysis-associated peritonitis is a common and serious complication in patients undergoing peritoneal dialysis. The occurrence of peritonitis not only increases hospitalization rates and length of hospital stay， but also raises patient mortality. Early diagnosis of peritoneal…
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