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Neural Regeneration Research
Scopus
ISSN 1673-5374 · Wolters Kluwer Medknow Publications · 5,083 articles in the index
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Journal Article
R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma
Glaucoma is characterized by chronic progressive optic nerve damage and retinal ganglion cell death. Although extensive research has been conducted on neuroprotection for retinal ganglion cells, there is still no treatment for clinical use. Recent evidence shows that extracellular vesicles isolated…
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Journal Article
Small extracellular vesicles derived from hair follicle neural crest stem cells enhance perineurial cell proliferation and migration via the TGF-β/SMAD/HAS2 pathway
Peripheral nerve defect repair is a complex process that involves multiple cell types; perineurial cells play a pivotal role. Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling; however, their clinical applications are limited by…
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Journal Article
Drug delivery strategies for neuroprotective therapy in ischemic stroke: Application of nanotechnology
The mechanisms underlying the pathophysiology of ischemic stroke are complex and multifactorial and include excitotoxicity, oxidative stress, inflammatory responses, and blood–brain barrier disruption. While vascular recanalization treatments such as thrombolysis and mechanical thrombectomy have…
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Journal Article
Tracing motor neurons and primary sensory afferents of the monkey spinal cord with cholera toxin subunit B
Nonhuman primates are increasingly being used as animal models in neuroscience research. However, efficient neuronal tracing techniques for labeling motor neurons and primary sensory afferents in the monkey spinal cord are lacking. Here, by injecting the cholera toxin B subunit into the sciatic…
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Journal Article
Latest progress and challenges in drug development for degenerative motor neuron diseases
Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions. They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage. The main types include amyotrophic lateral…
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Journal Article
Lnc_011797 promotes ferroptosis and aggravates white matter lesions
Recent evidence suggests that ferroptosis plays a crucial role in the occurrence and development of white matter lesions. However, the mechanisms and regulatory pathways involved in ferroptosis within white matter lesions remain unclear. Long non-coding RNAs (lncRNAs) have been shown to influence…
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Journal Article
Deep brain stimulation for the treatment of Alzheimer’s disease: A safer and more effective strategy
Alzheimer’s disease is the most common type of cognitive disorder, and there is an urgent need to develop more effective, targeted and safer therapies for patients with this condition. Deep brain stimulation is an invasive surgical treatment that modulates abnormal neural activity by implanting…
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Journal Article
Differential plasticity of excitatory and inhibitory reticulospinal fibers after spinal cord injury: Implication for recovery
The remodeling of axonal connections following injury is an important feature driving functional recovery. The reticulospinal tract is an interesting descending motor tract that contains both excitatory and inhibitory fibers. While the reticulospinal tract has been shown to be particularly prone to…
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Journal Article
Synaptic pruning mechanisms and application of emerging imaging techniques in neurological disorders
Synaptic pruning is a crucial process in synaptic refinement, eliminating unstable synaptic connections in neural circuits. This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms. The pruning process involves multiple molecular signals…
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Journal Article
Novel therapies for myasthenia gravis: Translational research from animal models to clinical application
Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting acetylcholine receptor, muscle-specific kinase, or related…
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Journal Article
Mitochondrial dynamics dysfunction and neurodevelopmental disorders: From pathological mechanisms to clinical translation
Mitochondrial dysfunction has emerged as a critical factor in the etiology of various neurodevelopmental disorders, including autism spectrum disorders, attention-deficit/hyperactivity disorder, and Rett syndrome. Although these conditions differ in clinical presentation, they share fundamental…
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Journal Article
Interleukin-17 family in health and immune diseases: From origin to clinical implications
The interleukin-17 family is the key group of cytokines and displays a broad spectrum of biological functions, including regulating the inflammatory cascade in various autoimmune and inflammatory diseases, such as multiple sclerosis, neuromyelitis optica spectrum disorder, myasthenia gravis…
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Journal Article
Neuroinflammation in neurodegenerative diseases: Focusing on the mediation of T lymphocytes
Neurodegenerative diseases are a group of illnesses characterized by the gradual deterioration of the central nervous system, leading to a decline in patients’ cognitive, motor, and emotional abilities. Neuroinflammation plays a significant role in the progression of these diseases. However, there…
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