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Neike lilun yu shijian
ISSN 1673-6087 · The editorial office of the Journal of Internal Medicine Concepts & Practice · 76 artikel di indeks
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Artikel Jurnal
Exploring and practicing “integrated residency and fellowship teaching rounds” in neurology
The standardized fellowship and the standardized residency training are important components of China's post-graduation medical education system. According to the national guidelines for standardized fellowship, it is necessary to establish a structured training system, which, together with…
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Anti-inflammatory effects and safety evaluation of decursin in atherosclerosis
ObjectiveTo investigate the anti-inflammatory effects and safety of decursin in atherosclerosis, and to verify its regulatory role in macrophage inflammatory responses. MethodsAn atherosclerosis model was established using apolipoprotein E deficient (ApoE-/-) male mice fed a high-fat diet. RAW…
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SOX9 promotes proliferation of fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting miR-204/-211
ObjectiveTo investigate the effect of sex determining region Y-box transcription factor 9 (SOX9) on the function of fibroblast-like synoviocyte (FLS) in rheumatoid arthritis (RA) by inhibiting micro-ribonucleic acid (miRNA)-204 and -211, and to explore the underlying mechanism. MethodsA…
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How to accurately understand and define early diagnosis of chronic obstructive pulmonary disease
This article discusses the challenges in the early diagnosis of chronic obstructive pulmonary disease (COPD) in light of the 2024 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report. It analyzes and distinguishes between the concepts such as “early COPD” and “pre-COPD”, noting…
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Relationship between triglyceride-glucose index and risk of acute myocardial infarction in patients with atrial fibrillation
ObjectiveTo explore the relationship between triglyceride-glucose (TyG) index and the occurrence of acute myocardial infarction (AMI) in patients with atrial fibrillation (AF). MethodsA total of 4 277 hospitalized AF patients from Beijing Tongren Hospital and Beijing Friendship Hospital affiliated…
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Roxadustat-induced central hypothyroidism in hemodialysis patients: a report of two cases
Hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) is a novel class of oral medications for treating renal anemia, but adverse drug events have been reported both in China and internationally in recent years. This article reports two cases of reversible central hypothyroidism following…
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Construction of sensitivity indicators for perioperative nursing quality in percutaneous coronary intervention
ObjectiveTo develop a scientifically reasonable set of sensitivity indicators for perioperative nursing quality in percutaneous coronary intervention (PCI). MethodsDomestic and international literature was retrieved, and the Johns Hopkins evidence-based nursing practice model was employed to…
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Development of a questionnaire on adult artificial airway management competence for ICU nurses and tests of its reliability and validity
ObjectiveTo develop a questionnaire on adult artificial airway management competence for intensive care unit (ICU) nurses. MethodsA preliminary questionnaire on the competence of ICU nurses in managing adult artificial airways was formulated through literature review, Delphi expert consultation and…
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Analysis of current status and influencing factors of opportunistic infections in Crohn disease
ObjectiveTo explore the current status and influencing factors of opportunistic infections in Crohn disease. MethodsData on demographic characteristics, disease features, treatment regimens and laboratory results of 369 patients with Crohn disease admitted to a tertiary grade A hospital in Shanghai…
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Application of therapeutic drug monitoring in immunosuppressant treatment of rheumatism
Rheumatism is a group of diseases primarily characterized by chronic inflammation or pain in the joints, muscles, and bones. The etiology is complex, and the disease processes are protracted and are often accompanied by immune system disorders. Immunosuppressive drugs are widely used in the…
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Artikel Jurnal
Mechanisms of frailty in postmenopausal women and the role of menopausal hormone therapy
Frailty is an age-related geriatric syndrome characterized by multisystem functional decline, which increases vulnerability to external stressors and raises the risk of adverse health outcomes. Epidemiological studies indicate a higher prevalence of frailty in women than in men, significantly…
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Progress in diagnosis and treatment of primary mediastinal large B-cell lymphoma
Primary mediastinal large B-cell lymphoma (PMBCL) is an aggressive non-Hodgkin lymphoma originating from thymic B cells. It typically presents as a rapidly growing anterior mediastinal mass, often accompanied by local symptoms such as chest tightness and shortness of breath, as well as systemic…
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Efficacy and safety analysis of luspatercept in patients with myelodysplastic syndromes with ringsideroblasts and refractory anemia
ObjectiveTo observe the clinical efficacy and safety of luspatercept in managing refractory anemia among patients with myelodysplastic syndrome with ring sideroblast (MDS-RS). MethodsA retrospective analysis was performed on consecutive MDS-RS patients with refractory anemia who were treated with…
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Teaching practice of endotracheal intubation in emergency department standardized residency training guided by the outcome-based education concept
ObjectiveTo evaluate the effect of outcome-based education (OBE) approach on endotracheal intubation training for emergency department residents during the standardized residency training. MethodsFrom August 2023 to July 2024, 48 emergency department residents undergoing standardized training at…
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Progress in noninvasive assessment of cardiac amyloidosis
Amyloidosis is a group of disorders caused by misfolded proteins that deposit in tissues and impair the function of vital organs. Systemic amyloidosis frequently involves the heart and is a leading cause of death in affected patients. Cardiac amyloidosis is difficult to diagnose and carries a poor…
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Research progress on the pathogenesis and clinical features of secondary acute myeloid leukemia
Secondary acute myeloid leukemia (sAML) refers to AML that occurs on the basis of a pre-existing hematological disease, or in patients with previous solid tumors who have undergone chemotherapy or radiotherapy. Compared with primary AML, the incidence of this type of disease is lower, but its…
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Diabetic cardiomyopathy: an underrecognized complication of diabetes mellitus
Diabetic cardiomyopathy initially referred to myocardial structural or functional abnormalities associated with type 2 diabetes mellitus (T2DM) in the absence of coronary heart disease, hypertension and/or obesity. However, relatively few T2DM patients can be diagnosed with diabetic cardiomyopathy…
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Research progress on biomarkers of acute mesenteric ischemia
Acute mesenteric ischemia (AMI) is a critical clinical emergency with an extremely high mortality rate. Early diagnosis and prognosis assessment are essential for improving patient outcomes. This article reviews the research progress on various biomarkers in the diagnosis and prognostic evaluation…
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Application of a digital ankle pump exercise check-in program in elderly patients with gastrointestinal cancer at high risk of venous thromboembolism
ObjectiveTo investigate the clinical application value of a digital check-in program-based ankle pump exercise intervention protocol in enhancing lower limb hemodynamics, improving exercise compliance, and preventing thrombosis in elderly gastrointestinal cancer patients at high risk of venous…
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Artikel Jurnal
Multi-omics technologies in the study of clinical heterogeneity of metabolic associated fatty liver disease
Metabolic associated fatty liver disease (MAFLD) is the most prevalent chronic liver disease worldwide and has become an important public health issue. MAFLD not only impairs liver function but is also closely associated with an increased risk of multi-system diseases, including cardiovascular…