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Zhongguo linchuang yanjiu, Vol 39, Iss 2, Pp 320 -324 (2026)
Scopus
ISSN 1674-8182 · The Editorial Department of Chinese Journal of Clinical Research · 912 artikel di indeks
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Artikel Jurnal
Research progress of novel biomarkers in diabetic kidney disease
"Diabetic kidney disease（DKD）is one of the most severe microvascular complications of diabetes mellitus and also a major cause of end- stage renal disease. Early diagnosis and intervention are crucial for delaying disease progression，whereas traditional biomarkers have certain limitations. In…
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Artikel Jurnal
Formation mechanism and research progress of the pre-metastatic niche in breast cancer
"The pre-metastatic niche（PMN）represents a microenvironment at potential metastatic sites，whose physiological alterations determine the efficiency of tumor metastasis and organotropism. The treatment of breast cancer with distant metastasis remains a significant clinical challenge. Recent advances…
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Artikel Jurnal
Small incision，big impact：the application of right axillary mini-thoracotomy in cardiac surgery
"The advent of minimally invasive cardiac surgery represents a pivotal milestone in cardiovascular surgical evolution，fundamentally revolutionizing the therapeutic paradigm of conventional sternotomy and propelling substantial advancements in this discipline. As an innovative refinement of…
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Artikel Jurnal
Effect of lactulose combined with magnesium sodium potassium sulfate salts on bowel preparation for colonoscopy in patients with constipation
Objective To investigate the efficacy of lactulose combined with magnesium sodium potassium sulfate salts on bowel preparation for colonoscopy in patients with constipation，aiming to improve the quality of bowel cleansing.Methods Prospectively，a total of 220 constipated patients admitted to the…
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Artikel Jurnal
Carotid artery lesions，hemorheological characteristics and their correlations with hearing loss in elderly patients with sudden deafness
Objective To investigate the characteristics of cervical vascular ultrasound and hemorheology in elderly patients with sudden deafness，as well as their correlations with the severity of hearing loss，so as to provide reference for clinical diagnosis. Methods A retrospective study was conducted. A…
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Artikel Jurnal
Changes and predictive value of blood KIM-1，UACR，and lipid metabolism in diabetic patients with early kidney injury
Objective To explore the changes and predictive value of serum kidney injury molecule-1（KIM-1），urinary microalbumin-to-creatinine ratio（UACR），and lipid metabolism in patients with diabetes and early kidney injury，and to provide new ideas for the prediction of early kidney injury in diabetic…
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Artikel Jurnal
Bulleyaconitine A combined with imrecoxib alleviates osteoarthritis pain by inhibiting NLRP3 inflammasome
Objective To explore the potential mechanism of bulleyaconitine A soft capsules in relieving osteoarthritis pain based on the changes of serum NOD- like receptor pyrin domain- containing protein 3（NLRP3）inflammasome level. Methods A prospective study was conducted on 80 patients with osteoarthritis…
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Artikel Jurnal
Clinical decision-making role of a mobile spinal cord line assessment system based on MRI imaging in posterior single-door surgery for multilevel cervical spondylotic myelopathy
Objective To investigate the value of the MRI-based mobile spinal cord line（mSC-line）evaluation system in clinical decision-making for posterior single-door laminoplasty in patients with multilevel cervical spondylotic myelopathy（MCSM）. Methods A retrospective cohort study was conducted，including…
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Artikel Jurnal
Phase I shortening and replantation-Phase II limb lengthening treatment for segmental mangled injury of the lower extremities
Objective To investigate the clinical efficacy and complication rates of treating lower limb segmental mangled injuries using a two-stage approach：initial shortening and replantation followed by secondary limb lengthening. Methods A retrospective analysis was conducted on the clinical data of 12…
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Artikel Jurnal
Comparison of efficacy between short-arm and long-arm braces in the treatment of triangular fibrocartilage complex injuries with stable distal radioulnar joint
Objective To compare and analyze the efficacy differences between short-arm cast brace fixation and long-arm brace fixation in the treatment of triangular fibrocartilage complex（TFCC）injuries with stable distal radioulnar joint. Methods A retrospective analysis was conducted on the clinical data of…
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Artikel Jurnal
Efficacy and safety of flumatinib as frontline treatment in elderly patients with newly diagnosed chronic myeloid leukemia in real-world
Objective To investigate efficacy and safety of flumatinib as frontline treatment in elderly patients with newly diagnosed chronic myeloid leukemia in real-world，providing a basis for clinical medication. Methods A total of 48 elderly patients with newly diagnosed chronic myeloid leukemia admitted…
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Artikel Jurnal
Value of left atrial volume index in predicting new-onset atrial fibrillation in patients with first attack acute myocardial infarction
Objective To investigate the clinical significance of July relationship between left atrial volume index（LAVI）and new-onset atrial fibrillation（NOAF）in patients with first attack acute myocardial infarction（AMI）.Methods A total of 214 AMI patients admitted to Cardiovascular Department of Huai’an…
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Relationship between remnant cholesterol and atrial fibrillation in patients with coronary atherosclerotic heart disease
"Objective To investigate the risk factors of coronary atherosclerotic heart disease（CHD）complicated with atrial fibrillation（AF）and its correlation with remnant cholesterol（RC）. Methods A retrospective analysis was conducted on 816 patients diagnosed with CHD in the Cardiovascular Department of…
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Artikel Jurnal
Risk factors and prognostic analysis of early atrial arrhythmias after lung transplantation
Objective To investigate the risk factors for early atrial arrhythmias（AAs）after lung transplantation and their impact on 1-year postoperative survival. Methods Clinical data of 307 adult patients who underwent lung transplantation at the Affiliated Wuxi People’s Hospital of Nanjing Medical…
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Artikel Jurnal
Comparison of cardiovascular disease risk prediction models in university staff based on carotid atherosclerosis biomarkers
Objective To systematically compare the predictive efficacy of different cardiovascular disease risk assessment models in university staff and identify an optimized tool for precision health management. Methods A retrospective cohort study was conducted，including university staff who consecutively…
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Artikel Jurnal
Individualized interventional treatment strategy selection and efficacy analysis for visceral artery aneurysms
Objective To analyze the interventional treatment and medium to long-term efficacy of visceral artery aneurysm（VAA），and to provide a reference for clinical selection of appropriate interventional treatment options.Methods A retrospective analysis was conducted on the clinical data of 67 VAA…
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Artikel Jurnal
Clinical analysis of 5 cases complicated with mediastinal ectopic parathyroid gland after surgery for secondary hyperparathyroidism
Objective To investigate the clinical characteristics of mediastinal ectopic parathyroid glands complicated after parathyroidectomy（PTX）in patients with secondary hyperparathyroidism（SHPT）. Methods From August 2016 to November 2024，among 321 patients who underwent PTX due to SHPT in China-Japan…
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Artikel Jurnal
Molecular mechanisms and translational applications of leader cell-mediated collective cell migration regulating re-epithelialization：functional integration and targeting strategies for lipid metabolism
"Wound healing is a spatiotemporally orchestrated biological process involving inflammatory regulation，proliferative repair，and tissue remodeling. Its core lies in the dynamic interplay between collective cell migration and metabolic networks. Re-epithelialization，the pivotal phase of wound…
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Artikel Jurnal
Analysis of the use of novel antitumor drugs in lung cancer treatment at Nanjing Chest Hospital from 2019 to 2023
Objective To monitor the clinical use and trend of novel antitumor drugs in the treatment of lung cancer，and provide references for improving the standardization and rationality of drug use and the optimization of relevant medical insurance policies. Methods A retrospective method was used to…
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Artikel Jurnal
Thermal ablation combined with gemcitabine and cisplatin regimen in patients with non-small cell lung cancer
Objective To explore the clinical efficacy of microwave thermal ablation combined with gemcitabine and cisplatin（GP）regimen in the treatment of non-small cell lung cancer（NSCLC）and its influence on the levels of circulating tumor DNA（ctDNA）and serum exosome markers. Methods A total of 82 NSCLC…