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Iraqi Journal of Pharmaceutical Sciences
Scopus
ISSN 1683-3597 · College of Pharmacy University of Baghdad · 1.257 artikel di indeks
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Artikel Jurnal
Assessing the Clinical Significance of Monocyte Chemoattractant Protein 1 and Protein Oxidation Products in Patients with Chronic Periodontitis
An essential chemokine called monocyte chemoattractant protein-1 (MCP-1) is in charge of initiating, controlling, and mobilizing monocytes to the sites of active severe periodontal inflammation. The purpose of the current study is to assess the serum levels of MCP-1 and protein oxidation products…
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Novel Variants in the MDR1 Gene with the Potential to Discriminate Steroid Responsiveness in Iraqi Children with Idiopathic Nephrotic Syndrome
Steroid-resistant idiopathic nephrotic syndrome (SRNS) is a leading cause of childhood end-stage renal disease, with diverse histological features and a challenging diagnosis. SRNS has been suggested to develop due to variations in the multidrug resistance 1 (MDR1) gene, with variable results from…
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Rizatriptan Benzoate Mucoadhesive Nasal Delivery for Targeting the Brain Pharmacokinetics of Nasal Delivery and Intravenous Solution in Wistar Rats
Owing to the restricted oral bioavailability of antimigraine drugs Rizatriptan Benzoate (RNB), nasal delivery was employed in lieu of enhancing the bioavailability and brain targeting through utilizing spanlastics nanovascular. This work sought to formulate RNB as mucoadhesive spanlastics…
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Tizanidine Cubosomal Nano Carriers as Transdermal Delivery System: Preparation and Characterization
Cubosomes are lipid-based nanostructured aqueous dispersions that form through a highly organized spontaneous self-assembly process. these lipid-based dosage forms can serve as effective carriers for lipophilic, hydrophilic drugs, thereby improving the therapeutic effectiveness of the drugs…
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Stevia-Derived Diterpenoids as Potential Dopamine D2 Receptor Antagonists for Insomnia and Schizophrenia Therapy: An In Silico Study
Insomnia is the second most common mental disorder and causes several health risks. Stevia water extract is a popular natural sweetener and promotes health benefits including antioxidant, anti-inflammatory, antimicrobial, antidiabetic, anticancer, anti-hypertension. This study investigates the…
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Exploring the In vivo Antiangiogenic Activity via CAM Assay and In vitro Cytotoxic Effects of Iraqi cultivated Leonotis leonurus Methanol Leaf Extract Against A2780 Human Ovarian Cancer Cells
The in vivo antiangiogenic activity and in vitro cytotoxic effects of methanol leaf extract of Leonotis leonurus (Lamiaceae) against A2780 human ovarian cancer cells are investigated in this work. Leonotis leonurus (L. leonurus), a fellow of the Lamiaceae family and commonly Referred to as "wild…
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Assessment of Adherence, Quality of Life, and Self-efficacy Among Iraqi Patients with Systemic Lupus Erythematosus: A Single-center Study
Systemic Lupus Erythematosus (SLE) is an immune-mediated disease with severe morbidity and tissue damage. Adherence to therapy in SLE patients remains a significant problem, and nonadherence can lead to poor disease outcomes and decreased quality of life. Self-efficacy is also a critical aspect of…
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Identifying Medication-Related Risk Factors among Iraqi Hospitalized Older Patients with Cardiovascular Disease: A Cross-Sectional Study
Cardiovascular drugs are the most commonly prescribed therapeutic classes among older adults, reflecting the high burden of cardiovascular diseases in those patients. Prescribing in elderly people is challenging due to age-related physiological changes, geriatric syndromes, and multi-morbidity…
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Optimization of Processing Parameters for the Preparation of Nimodipine-Loaded Transferosomes by Solvent Evaporation-Hydration Method
Nimodipine is a vasodilator medicinal agent approved for the prevention of cerebral vasospasm, a major risk factor that causes deaths in patients diagnosed with subarachnoid hemorrhage. The current marketed products of this drug are associated with challenges such as frequent dosing orally, or…
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The Potential for Enhanced Systemic Delivery of Nimodipine Loaded Polymeric Nanoparticles via Bilayer Dissolving Microneedles
Nimodipine (NID) is used for the prevention of ruptured intracranial aneurysms and subarachnoid haemorrhage (SAH). The objective of study using the benefits of a combined approach of polymeric nanoparticles and microneedles to fabricate NID as polymeric nanoparticles (NID-NPs) loaded in a bilayer…
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Investigate the Factors Influencing the Formulation of Aceclofenac-Loaded Nanosponges Based on Eudragit L100
Among the many NSAIDs generated from phenyl acetic acid is Aceclofenac, or ACE. Its antipyretic, analgesic, and anti-inflammatory effects are noteworthy. However, the substance's delayed dissolution, limit permeability, and inadequate bioavailability are caused by its low solubility in water, which…
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Formulation and Evaluation of Lercanidipine HCL Loaded Nanomicelles
Among the strong calcium channel blockers, lercanidipine hydrochloride (LER) has been shown to be useful in reducing blood pressure by acting on L-type calcium channels. Nevertheless, the main drawback of lercanidipine is that it is a BCS class II medication with poor solubility and a 10% oral…
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