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Клиническая микробиология и антимикробная химиотерапия
Scopus
ISSN 1684-4386 · Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy · 471 articles in the index
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Antimutant activity of the combination of colistin and rifaximin in selective digestive decontamination: validation in a dynamic flow-through system
Objective. Introduction. Selective digestive decontamination of the digestive tract (SDD) with non-absorbable antibiotics is considered a promising approach to reduce the risk of infections in critically ill patients. However, the widespread circulation of multidrug-resistant microorganisms…
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Lower respiratory tract microbiome in patients with pulmonary tuberculosis and HIV coinfection
Objective. To investigate the bacterial and fungal microbiota of the lower respiratory tract in hospitalized patients with tuberculosis and HIV coinfection. Materials and Methods. A total of 378 sputum samples from 147 patients at the Novosibirsk Tuberculosis Research Institute (Ministry of Health…
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Immunogenetic predictors of severe sepsis: role of functional polymorphisms
Objective. To identify associations between functional polymorphisms in genes of the immune, endothelial, and coagulation systems and the severity and outcomes of sepsis to validate genetic risk predictors. Materials and Methods. This single-center prospective study included 124 patients aged of 1…
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Etiological structure of community-acquired urinary tract infections in children and adolescents in Krasnoyarsk region and antibiotic resistance of the leading pathogen – Escherichia coli
Objective. To study structure of pathogens of community-acquired urinary tract infections (UTI) in children and adolescents under 18 years of age subpopulation of the Krasnoyarsk region as well as the activity of antimicrobials against the leading pathogen in order to optimize local empirical…
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Contribution of antimicrobial use surveillance to the prevention of resistance selection
The spread of drug-resistant pathogens, especially multidrug resistant ones, dictates a reassessment of approaches to antimicrobials’ use in the Russian healthcare system. Antimicrobial pharmacotherapy surveillance providing healthcare specialists with up-to-date information is a crucial tool for…
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Machine learning methods in predicting antimicrobial resistance
Antimicrobial resistance poses a significant global threat to healthcare systems worldwide. The high cost and short lifespan of new antibiotics due to the rapid evolution of resistance exacerbate this crisis, prompting exploration of diverse strategies to combat AMR. Within the context of AMR…
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Evaluation of linezolid pharmacokinetics and pharmacodynamics in preterm infants
Objective. To study pharmacokinetics (PK) and develop a pharmacokinetic/pharmacodynamic (PK/PD) model of linezolid for preterm infants, based on therapeutic drug monitoring (TDM) data. Materials and Methods. The PK/PD analysis included data from therapeutic drug monitoring (TDM) of 24 premature…
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Resolution of the Round Table Pneumonia. From penicillin to the present day: what has changed over the last hundred years
As part of the VIII scientific and practical conference with international participation, "Modern Challenges in Infection Therapy (SVETI 2026)," held in Moscow on March 27, 2026, a roundtable discussion entitled "Pneumonia. From Penicillin to the Present Day: What Has Changed in the Last Hundred…
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Etiological structure of respiratory tract infections in patients of different age groups with primary ciliary dyskinesia
Objective. To study etiological structure of respiratory tract infections in patients with primary ciliary dyskinesia (PCD) across different age groups. Materials and Methods. A total of 173 patients with a confirmed diagnosis of PCD from various regions of the Russian Federation were examined from…
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Current concepts of the role of viruses as an etiological factor in sepsis
Sepsis is a life-threatening condition resulting from a dysregulated immune response to infection and characterized by multiple organ dysfunction. Historically, the contribution of viruses to sepsis pathogenesis has been underestimated, largely due to diagnostic limitations and the established…
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Local treatment of wound infection: what’s new in the last decade?
Local treatment of wound infections remains the preferred method of therapy, reducing the risk of adverse systemic reactions while providing high therapeutic concentrations in wound tissues. This article is an analysis of clinical studies of local therapy of acute and chronic wounds over the past…
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Genome-based analysis of the taxonomic structure of the genus Stenotrophomonas
Objective. To analyze the current taxonomic structure of the genus Stenotrophomonas based on genomic data, taking into account limitations associated with nomenclatural validation processes. Materials and Methods. A reference dataset was constructed using taxonomic information from LPSN (List of…
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Macrocidins A and Z: assessment of antibacterial and antibiofilm activity
Objective. To compare antibacterial activity of macrocidins A and Z against staphylococci and their effect on staphylococcal biofilms. Materials and Methods. The antibacterial activity of macrocidins A and Z produced by Didymella baileyae VIZR 1.53 was studied by serial dilution method against 120…
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An outbreak of Ralstonia insidiosa infection: a case series and an epidemiologic investigation in a pediatric hospital
Ralstonia insidiosa is not usually considered an etiologically significant microorganism capable of causing infections. This article presents a retrospective analysis of a series of hospital-acquired infections caused by R. insidiosa in 8 comorbid patients at a pediatric hospital from August 2023…
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PIKAP study: physicians’ preferences for drug selection and management of pregnant women with bacterial genitourinary infections
Objective. To analyze physicians’ preferences regarding the pharmacotherapy of bacterial genitourinary infections (UTI) in pregnant women and assess their compliance with current clinical guidelines. Materials and Methods. The study was conducted over 2018–2022 using an anonymous questionnaire…
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Antimicrobial resistance – are we aware of all the sources?
The problem of antimicrobial resistance represents one of the most urgent and complex problems of modern healthcare. The measures that are being taken today to control antimicrobial resistance, however, cannot be considered satisfactory, and we are seeing an increasing prevalence of…
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Regional distribution of antibiotic resistance in Bacteroides spp. and Clostridium perfringens strains isolated from coloproctological patients in the Russian Federation
Objective. To study susceptibility of clinical Bacteroides spp. and Clostridium perfringens isolates to antimicrobial agents across different regions of the Russian Federation and to identify regional patterns of antimicrobial resistance. Materials and Methods. The study included 1,685 isolates of…
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Drug susceptibility of Mycobacterium avium isolated from patients with mycobacteriosis with positive and negative HIV status
Objective. Comparative assessment of in vitro susceptibility of M. avium isolated from patients with mycobacteriosis (MB) with positive and negative HIV status. Materials and Methods. M. avium isolates of were revealed during 2018–2023 from clinical samples of 402 adult patients (≥ 18 years old) in…
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Comparative analysis of antimicrobial resistance monitoring methodologies at the local healthcare level
Despite ongoing efforts by various countries to combat antimicrobial resistance (AMR), the problem remains a global-scale threat, particularly in the context of nosocomial infections, where resistant pathogens are associated with high mortality. Global (GLASS) and national (AMRmap) AMR monitoring…
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How to choose an appropriate probiotic: a guide for clinicians
The annual increase in probiotic usage is nothing short of phenomenal. Given the large volume of information on beneficial microorganisms, it can be challenging for clinicians to select the most suitable probiotic for a patient. This article provides specific advice on probiotic selection for…