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International Journal of Analytical Chemistry
Scopus
ISSN 1687-8779 · Wiley · 857 articles in the index
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Journal Article
Greenness, Whiteness, and Blueness Assessment With a Novel and Fully Validated HPLC Method for Simultaneous Analysis of Lumacaftor and Ivacaftor in Sweat
Sweat is an alternative biological fluid to plasma, urine, hair, and saliva, and it is promising for various pharmaceutical research types. Excessive sweating is one of the symptoms of cystic fibrosis, a hereditary disease. In this study, an easy, simple, applicable, and economical HPLC method was…
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Journal Article
Development and Validation of a Robust RP-HPLC Method for Quantifying Dasatinib in Self-Microemulsifying Drug Delivery Systems
Dasatinib, a therapy for chronic myeloid leukemia, suffers from poor bioavailability. Self-microemulsifying drug delivery systems (SMEDDSs) are used to improve its dissolution. This study aimed to develop and validate a novel reverse-phase high-performance liquid chromatography (RP-HPLC) method for…
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Journal Article
Determination of Eight Benzene Homologs in Ambient Air and Indoor Air in Residential Areas by Secondary Thermal Desorption–Gas Chromatography
This study developed and comprehensively validated an optimized analytical method based on secondary thermal desorption–gas chromatography (STD-GC) for the simultaneous determination of eight key benzene homologs in ambient and indoor air of residential areas. Compared to solvent desorption and…
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Journal Article
Validated RP-HPLC-UV Method for Simultaneous Quantification of Aminophenazone, Dipyrine, and Chlorpheniramine Maleate in Pharmaceutical Formulations Considering Dipyrine Decomposition
Aminophenazone, dipyrine, and chlorpheniramine maleate combined drug is used as antipyrine and analgesic. In this study, a rapid, robust, and straightforward high-performance liquid chromatographic (HPLC) technique was developed, optimized, and validated for simultaneous analysis of aminophenazone…
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Journal Article
Analysis of Fingerprint Profiles of Flavonoid Compounds in Rock Tea of Different Ages
This study established a chromatographic fingerprint analysis method for aged rock tea using ultra-high performance liquid chromatography–mass spectrometry (UPLC–MS) technology to profile its chemical components. The chromatographic separation showed excellent performance, with more than 30…
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Journal Article
Greenness Evaluation of Piracetam Detection Through Spectrofluorimetric Method With Shilajit-Derived Metal Oxide Nanosensors
Piracetam (PRM) is a nootropic commonly used to improve cognitive function, memory, and learning ability. This method introduces a new spectrofluorimetric strategy for the identification of PRM, using metal oxide nanomaterials from Shilajit extract in a micellar medium. The technique is based on a…
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Journal Article
A High-Performance Liquid Chromatography Method for Simultaneous Analysis of Naringin, Ascorbic Acid, and Caffeine: Design, Development, and Validation
The simultaneous quantification of ascorbic acid, caffeine, and naringin is of significant interest due to their potential therapeutic applications, particularly in the prevention and management of colorectal cancer. While numerous HPLC methods exist for the individual determination of each…
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Journal Article
Schiff Base–Derived Colorimetric Chemosensor for Fe3+ Detection: Synthesis, Mechanistic Insights, and Real-World Applications in Water Quality Monitoring
A Schiff base colorimetric chemosensor (H2L), synthesized from 2-hydroxy-1-naphthaldehyde and anthranilic acid, was developed for selective Fe3+ detection. In a DMF:H2O (9:1, v/v) medium, H2L exhibited a distinct and selective response to Fe3+ among common competing cations, producing a visible…
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Journal Article
Quantification of 24,25-Dihydroxyvitamin D3 in Serum Using LC–MS/MS With Derivatization and Lipid-Removal Filtration
Accurate assessment of vitamin D metabolism is crucial not only for the diagnosis and treatment of disorders related to bone health and calcium homeostasis but also for understanding its broader physiological roles in immunity, cellular differentiation, cardiovascular regulation, and endocrine…
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Journal Article
Analysis of Illicit Street Heroin Seized in Pakistan by Gas Chromatography–Mass Spectrometry (GC-MS) for Identification of Adulterants and Impurities
Heroin abuse poses a significant public health and law enforcement challenge globally, with concerns in Pakistan due to the prevalence of illicit street heroin and limited data on its composition. This study analyzed 706 heroin samples seized between 2017 and 2022 using gas chromatography–mass…
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Journal Article
Formulation and Delivery Systems of Cocaine and Methamphetamine Scent Mimics
Narcotic scent mimics, which are chemicals that emit a perceivable scent similar to that of the illicit drug but do not possess the health and addiction risks of the drug, have applications ranging from canine training in law enforcement agencies to antinarcotic public education. However, low-cost…
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Journal Article
Optimizing Fuel-Based Environmental Strategies for Stack Emissions From Zigzag and Fixed Chimney Bull’s Trench Kiln (FCBTK) Brick Kilns: A Comparative Analysis
Pakistan has around 20,000 brick kilns, constituting 3% of global brick production. Consequently, air pollution and air quality indicators have significantly deteriorated. In this study, we examined the effect of different fuel types, such as coal, coal + wheat straw, and coal + rice straw, on…
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Journal Article
Assessment of Groundwater Quality Using the Water Quality Index (WQI) in Woreillu Town, Ethiopia
Groundwater is a vital source of drinking water in Woreillu Town, Ethiopia; however, its quality may be affected by both natural hydrogeochemical processes and anthropogenic activities. This study evaluated the suitability of groundwater for drinking purposes using physicochemical parameters and…
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Journal Article
Level of Ascorbic Acid, Total Phenolic, Flavonoid, Tannin, and Antioxidant Activity of Lady Finger (Abelmoschus esculentus) From Addis Ababa, Ethiopia
Oxidative stress, resulting from an imbalance between reactive oxygen species and cellular defense mechanisms, is the fundamental driver of various chronic metabolic disorders. Consequently, the consumption of antioxidant-rich vegetables is essential for public health as a strategy to mitigate free…
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Journal Article
Innovative Biosensor Platforms for the Detection of Metformin in Diabetes Management
Metformin, a widely prescribed antihyperglycemic agent, plays a crucial role in the management of Type 2 diabetes by reducing hepatic glucose production and increasing insulin sensitivity. Its effectiveness in glucose regulation has made it a cornerstone in diabetes care, necessitating precise…
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Journal Article
Preliminary Descriptive Study on the Conservation of Human Sweat Odor: Impact of Storage Temperature and Duration on the Stability of Volatile Organic Compounds in Sorbent Samples
Volatile organic compounds (VOCs) emitted in human matrices have gained attention for their potential in noninvasive disease detection, utilizing canine olfaction and chemical analysis. However, the stability of these VOCs under various storage conditions remains poorly understood, presenting a…
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Journal Article
A Stability-Indicating RP-HPLC Method for Simultaneous Determination of Triclabendazole and Levamisole in Oral Suspension Formulation
A fast, simple, and precise stability-indicating high-performance liquid chromatographic (HPLC) method was developed for analysis of triclabendazole (TBZ) and levamisole (LEV) in oral suspension. Using a mobile phase composed of acetonitrile, methanol, and water (50:40:10, v/v/v), with the pH…
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Journal Article
Measurement of Stable Carbon Isotope Ratio of Volatile Organic Compounds Using Thermal Desorption-Gas Chromatography-Combustion-Isotope Ratio Mass Spectrometry
This paper presents a method combining a thermal desorption (TD) unit with gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) to determine compound specific δ13C values of seven VOCs (benzene, toluene, ethylbenzene, m/p-xylene, o-Xylene, styrene, and cumene). The main…
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Journal Article
Heavy Metal Concentration in Swiss Chard (Beta vulgaris ssp. cicla L.) Cultivated Along River Banks in Addis Ababa, Ethiopia
This study employed flame atomic absorption spectrophotometry to determine the levels of selected heavy metals in Swiss chard. Samples were collected from three vicinities of Addis Ababa: Akaki, Sebeta, and Kotebe. A 0.5-g dried and powdered sample was analyzed using the wet digestion method with…