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International Journal of Cell Biology
Scopus
ISSN 1687-8884 · Wiley · 330 artikel di indeks
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Artikel Jurnal
Integrative Meta-Analysis and WGCNA Reveal Candidate Diagnostic Hub Genes in Clear Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC) remains poorly understood at the genetic level. In this study, 12 GEO microarray datasets were combined, and meta-analysis and multiparameter gene prioritization were used to reveal candidate diagnostic biomarkers. Improved preprocessing and analysis were…
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The HDAC Inhibitor Butyrate Reduces SOD1 Aggregation and Improves Motor Function in C. elegans and Cellular Models of ALS
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterised by motor neuron loss and protein aggregation, commonly driven by mutations in superoxide dismutase 1 (Sod1). Recent evidence implicates gut microbiota–derived metabolites, such as butyrate, in modulating…
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Radioprotective Effects of Vitamin C, Cimetidine, and Famotidine on Lipid Peroxidase and Hepatic Glutathione Levels in Mouse Liver
Radiation therapy is one of the most effective treatments for approximately 60% of patients with cancer. During radiation exposure, the overproduction of reactive oxygen species (ROS) disrupts the lipid layer of the membrane, leading to subsequent peroxide radical formation. Cimetidine (Cim) and…
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Preservative Effectiveness of Lactic Acid Bacteria on Fruits and Vegetables
Conclusion: LAB are highly effective in preserving fruits and vegetables through multiple mechanisms, offering significant benefits in terms of extended shelf life, improved safety, enhanced nutritional value, and better sensory qualities. Ongoing research and technological advancements are…
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Important Aspects of siRNA Design for Optimal Efficacy In Vitro and In Vivo
siRNA is a versatile tool with practical applications in various fields, such as fundamental research, therapeutic development, and plant genetics. A few siRNA therapeutics have been FDA-approved, such as Onpattro (patisiran) and Leqvio (inclisiran) to treat hereditary transthyretin amyloidosis and…
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The Effect of Exposure to Mobile Phones on Electrical Cardiac Measurements: A Multivariate Analysis and a Variable Selection Algorithm to Detect the Relationship With Mean Changes
Conclusion: The observed modifications in cardiac electrical measurements due to mobile phone EMF exposure are attributed to the effects of EMF itself, with no impact from BMI on the extent of these changes.
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A Short Post-Reattachment Ultrasensitive Window of Time in Human Cancer Cells as Therapeutic Target of Prolonged Low-Dose Administration of Specific Compounds
Prolonged low-dose administration (PLDA) of several FDA-approved drugs for noncancer conditions or dietary compounds is associated with a lower incidence of specific types of cancers and with the lower formation of metastasis. However, the underlying mechanism is unknown; there is a discrepancy…
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A Comparative Study on the Effects of Mesenchymal Stem Cells and Their Conditioned Medium on Caco-2 Cells as an In Vitro Model for Inflammatory Bowel Disease
Recent research indicates that mesenchymal stem cells (MSCs), known for their anti-inflammatory and anti-infectious properties, could be a promising alternative for treating inflammatory diseases such as inflammatory bowel disease (IBD). This study examined how MSCs and their derivatives, when…
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Mitotic Kinases Aurora-A, Plk1, and Cdk1 Interact with Elk-1 Transcription Factor through the N-Terminal Domain
Elk-1 is a member of the ETS domain transcription factor superfamily that is phosphorylated upon mitogen-activated protein kinase (MAPK) pathway activation, which in turn regulated its interaction with partner protein serum response factor (SRF), leading to formation of a ternary complex with DNA…
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The Role of Bcl-2 Family Proteins and Sorafenib Resistance in Hepatocellular Carcinoma
Liver cancer has been reported to be one of the most malignant diseases in the world. It is late diagnosis consequently leads to a difficult treatment, as the cancer reached an advanced stage. Hepatocellular carcinoma (HCC) is the primary type of cancer diagnosed in the liver, with deadly…
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Visual Neuroprostheses for Impaired Human Nervous System: State-of-the-Art and Future Outlook
Aim of the Study: This review discusses four main types of visual neuroprosthesis approaches, including retinal approaches, lateral geniculate nucleus (LGN) approaches, optic nerve approaches, and cortical approaches, along with their constituent electrodes, metals, and stimulation patterns. Using…
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Acute Genetic Damage Induced by Ethanol and Corticosterone Seems to Modulate Hippocampal Astrocyte Signaling
Astrocytes maintain CNS homeostasis but also critically contribute to neurological and psychiatric disorders. Such functional diversity implies an extensive signaling repertoire including extracellular vesicles (EVs) and nanotubes (NTs) that could be involved in protection or damage, as widely…
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Comparative Transcriptomic Analyses of a Vero Cell Line in Suspension versus Adherent Culture Conditions
The Vero cell line is the most used continuous cell line for viral vaccine manufacturing. Its anchorage-dependent use renders scaling up challenging and operations very labor-intensive which affects cost effectiveness. Thus, efforts to adapt Vero cells to suspension cultures have been invested, but…
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The Molecular Basis of Wnt/β-Catenin Signaling Pathways in Neurodegenerative Diseases
Defective Wnt signaling is found to be associated with various neurodegenerative diseases. In the canonical pathway, the Frizzled receptor (Fzd) and the lipoprotein receptor-related proteins 5/6 (LRP5/LRP6) create a seven-pass transmembrane receptor complex to which the Wnt ligands bind. This…
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AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia
The role of hypoxia in benign meningiomas is less clear than that in the malignant meningiomas. Hypoxia-induced transcription factor 1 subunit alpha (HIF-1α) and its downstream signaling pathways play a central role in the mechanism of hypoxia. HIF-1α forms a complex with the aryl hydrocarbon…
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RuX: A Novel, Flexible, and Sensitive Mifepristone-Induced Transcriptional Regulation System
Inducible gene regulation methods are indispensable in diverse biological applications, yet many of them have severe limitations in their applicability. These include inducer toxicity, a limited variety of organisms the given system can be used in, and side effects of the induction method. In this…
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Assessment of Cytogenotoxicity of Plastic Industrial Effluent Using Allium cepa Root Tip Cells
The effects of plastic effluent in Kano Metropolis on cytotoxicity and genotoxicity were examined using a test on Allium cepa root cells. The physicochemical characteristics of industrial wastewater were assessed, and the results showed values that were higher than the required criteria; this…
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miRNAs: The Key Regulator of COVID-19 Disease
As many parts of the world continue to fight the innumerable waves of COVID-19 infection, SARS-CoV-2 continues to sculpt its antigenic determinants to enhance its virulence and evolvability. Several vaccines were developed and used around the world, and oral antiviral medications are being…