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Allergy, Asthma & Clinical Immunology
Scopus
ISSN 1710-1492 · BMC · 1,182 articles in the index
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Journal Article
Effects of sublingual immunotherapy for dust mite on Th 17 / Treg cells in children with asthma
Abstract Objective observing the clinical effects of dust mite sublingual immunotherapy (SLIT) on children with asthma, changes of Th17 / Treg cells and related cytokines in order to investigate the possible pathological mechanism of immune tolerance induced by SLIT. Methods Sixty children with…
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Journal Article
WHIM syndrome in a child without the classic tetrad: a case confirmed by de novo CXCR4 mutation
Abstract Background WHIM syndrome is a rare autosomal dominant primary immunodeficiency characterized by the classical tetrad of warts, hypogammaglobulinemia, infections, and myelokathexis. The majority of cases are associated with gain-of-function mutations in the CXCR4 gene. Recent studies have…
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Journal Article
Early-life antibiotics and childhood allergy: a multi-center cohort
Abstract Background Antibiotic use in infants is hypothesized to alter the gut microbiota, influencing immune system dysregulation and increasing allergy risk. We aim to assess the prevalence of allergic diseases in children treated with different classes of antibiotics in early life. Methods A…
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Journal Article
Advancing allergen characterization in Perilla seed: an oil body purification approach
Abstract Perilla seed (PS), a common food in East Asia, has emerged as a leading cause of seed-induced anaphylaxis in Korean children, yet its allergenic proteins remain unidentified. Oleosins, hydrophobic oil-body (OB)–associated storage proteins, are recognized allergens in peanuts, hazelnuts…
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Journal Article
CTLA-4 haploinsufficiency presenting with chronic myeloid leukemia, bullous pemphigoid, and PLA2R-positive membranous nephropathy: a case report
Abstract Background Cytotoxic T-lymphocyte–associated protein 4 (CTLA-4) haploinsufficiency is a primary immune-regulatory disorder characterized by T-cell overactivation and multisystem autoimmunity. Malignancies, particularly lymphomas and gastric cancer, have been reported in approximately…
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Journal Article
Mepolizumab reduces healthcare resource utilization in patients with chronic rhinosinusitis with nasal polyps: a linked EMR and claims-based pre-post study
Abstract Background Real-world evidence on the effectiveness of mepolizumab at reducing healthcare resource utilization (HCRU) and clinical symptoms in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) is limited. Methods This real-world study used linked electronic medical record and…
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Journal Article
One size does not fit all: uncontrolled T2 inflammation on tezepelumab—a case series
Abstract Background Tezepelumab is the most recent human monoclonal antibody in the therapeutic arsenal of patients with severe uncontrolled asthma. It neutralizes thymic stromal lymphopoietin (TSLP). Phase 2 and phase 3 studies showed a significant reduction in asthma exacerbations in the severe…
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Journal Article
Gender and geographic representation in editorial boards of allergy and immunology journals
Abstract Background Editorial boards shape academic publishing, yet disparities in gender and geographic representation persist across disciplines. To date, these disparities have not been comprehensively investigated in Allergy and Immunology journals. Objective To examine gender and geographic…
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Journal Article
Asthma control and exacerbation risk following SARS-CoV-2 infection in the post-acute COVID-19 phase: a systematic review
Abstract Background The post-acute respiratory consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with asthma remain incompletely understood. While early coronavirus disease 2019 (COVID-19) research focused on acute infection severity, less is…
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Journal Article
Parent perspectives on guided self-care approaches to ensure timely access to therapy in infants with food allergy
Abstract Background Early allergen immunotherapy (AIT), including oral immunotherapy (OIT), is increasingly recognized as a disease-modifying intervention for infants with Immunoglobulin E (IgE)-mediated food allergy. However, limited access to allergy specialists and long wait times often prevent…
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Journal Article
Frequency and severity of systemic reactions during beta-lactam skin testing in adults with immediate hypersensitivity allergy
Abstract Hypersensitivity to beta-lactams (BL) is the most frequent drug allergy, and skin testing (ST) remains the first-line diagnostic tool. Although generally safe, systemic reactions (SR) during ST are a concern. We conducted a 7-year ambispective study (2018–2025) including 216 adults with…
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Journal Article
Declining venom immunotherapy: patient characteristics and clinical outcomes
Abstract Background A largely unknown proportion of Hymenoptera venom-allergic patients do not undergo venom immunotherapy (VIT) despite positive allergy testing and counselling. We aimed to identify factors associated with the refusal of VIT, and evaluate the natural course of venom allergy in…
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Journal Article
Triggers, clinical spectra and outcomes of pediatric anaphylaxis in a tertiary center: impact of comorbidities and cofactors on severity
Abstract Purpose Anaphylaxis is a potentially life-threatening systemic hypersensitivity reaction. While triggers, clinical manifestations, and severity are influenced by age and sociocultural factors, most evidence regarding the impact of comorbidities and cofactors comes from adult studies. This…
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Journal Article
Longitudinal FeNO monitoring in pediatric asthma: association of FeNO and its trajectory patterns with asthma control status
Abstract Background Fractional exhaled nitric oxide (FeNO) is a non-invasive biomarker of type 2 inflammation with potential for personalized asthma management. However, the longitudinal patterns of FeNO and their association with childhood asthma control remain insufficiently characterized…
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Journal Article
Preventive effect of heat-killed Lactiplantibacillus plantarum FM8 in an ovalbumin-induced food allergy murine model
Abstract Background Paraprobiotics, the non-viable microbial cells with health benefits, have gained interest as candidates for preventing food allergies owing to their safety and stability. Heat-killed Lactiplantibacillus plantarum FM8 (FM8) has been reported to induce interleukin (IL)-10…
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Journal Article
Oral immunotherapy for the treatment of pumpkin seed allergy: a real-world case series
Abstract Background Pumpkin seed, a member of the Cucurbitaceae family, is increasingly consumed because of its high protein content and perceived health benefits. Along with its growing use, cases of pumpkin seed allergy are being reported. However, data on pumpkin seed allergy and oral…
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Journal Article
Would the number of new cases of hereditary angioedema decrease due to declining fertility rates?
Abstract Hereditary angioedema (HAE) is a rare, potentially life-threatening disorder caused by autosomal dominant mutations in the SERPING1 gene, leading to deficiency or dysfunction of C1 esterase inhibitor. Recent estimates of global HAE prevalence are 1.22 per 100,000 individuals. With total…
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Journal Article
Unrecognized ciliary motility disorders in neutrophilic severe asthma exacerbations
Abstract Background Airway bacterial infections are frequent in severe asthma and are often under-appreciated as contributors to symptoms and exacerbations. We report our experience using integrative diagnostic methods to identify ciliary motility disorders as contributors to neutrophilic…
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Journal Article
Knowledge, attitudes, and practices toward food allergies among early childhood educators in Taiwan: a cross-sectional study
Abstract Background The prevalence of food allergies among Taiwanese children has risen to 10.4%, which is notably higher than that in many other Asian regions. However, despite this trend, Taiwan lacks specialized legislation or standardized national protocols for the management of food allergies…
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Journal Article
Development and validation of a quality of life scale for pediatric mastocytosis
Abstract Background Mastocytosis imposes a considerable burden on patients’ quality of life. While validated QoL instruments are available for adults with systemic mastocytosis, no disease-specific quality-of-life measure has yet been developed for pediatric populations. Objective This study aimed…
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