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Research in Pharmaceutical Sciences
Scopus
ISSN 1735-5362 · Wolters Kluwer Medknow Publications · 633 artikel di indeks
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Artikel Jurnal
Synergistic cytotoxicity of recombinant IGFBP-3 and cisplatin in HPV18-positive HeLa cells via NF-κB inflammatory modulation
Background and purpose: Insulin-like growth factor-binding protein-3 (IGFBP-3), a tumor suppressor and inhibitor of nuclear factor kappa B (NF-kB), has emerged as a promising candidate for therapeutic application across diverse pathological conditions. Given NF-kB’s role in cervical cancer…
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Artikel Jurnal
Effects of PPARα, PPARγ, and dual PPARα/γ agonists on liver tissue and biochemical markers in NAFLD-induced Wistar rats
Background and purpose: Non-alcoholic fatty liver disease (NAFLD) is the most common liver-related metabolic disorder worldwide, affecting approximately 25% of the global population. Peroxisome proliferator-activated receptor (PPAR) agonists play an important role in NAFLD management through…
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Artikel Jurnal
Effects of pomegranate seed extract and ellagic acid on miR-16-5p and miR-34a-5p expression, cell cycle, and apoptosis in MCF-7 cells
Background and purpose: The expression of Homo sapiens (has)-miR-16-5p and hsa-miR-34a-5p with anti-tumor effects is downregulated in cancer cells. To maintain these gene expressions in cancer cells, we evaluated the effects of pomegranate seed extract (PSE) and ellagic acid (EA) on hsa-miR-16-5p…
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Artikel Jurnal
Ferula gummosa in colorectal cancer: a bioinformatics and experimental validation study
Background and purpose: Colorectal cancer (CRC) is a significant global health challenge, necessitating a comprehensive molecular understanding for personalized treatments. Molecular profiling has elucidated key biomarkers that are essential for prognosis, treatment responsiveness, and targeted…
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Artikel Jurnal
Enhancing soluble expression and purification of a bispecific scFv antibody in Escherichia coli using chaperones
Background and purpose: The use of a bispecific antibody engineered as a tandem single-chain fragment variable antibody (scFv-BsAb) offers several advantages over full-length antibodies, including enhanced tissue penetration and the potential for production in bacterial cells. However, production…
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Artikel Jurnal
New 5-(pyridin-3-yl)-1,3,4-oxadiazoles derivatives as VEGFR2 inhibitors: in silico study, synthesis, and cytotoxicity evaluation
Background and purpose: Angiogenesis, regulated by vascular endothelial growth factor receptor 2 (VEGFR-2), has a key role in tumor progression, especially in common cancers, including colorectal and renal cancer. Inhibiting VEGFR-2 is a promising therapeutic approach. This research aimed to…
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Artikel Jurnal
Molecular docking, synthesis, and cytotoxic evaluation of novel quinazoline-quinazolinone hybrid compounds
Background and purpose: Cancer represents a significant public health challenge and a leading cause of mortality globally. Quinazolinones represent a class of privileged structures that exhibit a broad spectrum of biological activities such as anticancer, antihypertensive, antifungal…
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Artikel Jurnal
Caffeic acid phenethyl ester protects mice against nicotine-induced seizures by attenuating oxidative stress and inflammation
Background and purpose: A seizure is a neurological disorder in the brain that is caused by changes in the function of brain neurons. Caffeic acid phenetyl ester (CAPE), as a polyphenol, has antioxidant, antiinflammatory, and anticancer effects. Since the effects of CAPE on the neurotoxins and…
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Artikel Jurnal
Thymoquinone and pentoxifylline modulate 5-fluorouracil-induced senescence and apoptosis in colorectal cancer spheroids
Background and purpose: Targeting senescent tumor cells with senotherapeutic agents represents a novel therapeutic strategy in overcoming chemotherapy resistance during 5-fluorouracil (5-FU) treatment of colorectal cancer (CRC). This study aimed to evaluate the senotherapeutic potential of…
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Artikel Jurnal
Aseptic meningitis induced by monoclonal antibodies used in cancer treatment: a systematic review
Background and purpose: Monoclonal antibodies (MAbs) have revolutionized cancer treatment but are associated with a spectrum of adverse events, including neurological complications. Understanding the mechanism and management of complications is crucial for optimizing patient care. The present…
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Artikel Jurnal
In silico anti-leishmanial potential of algal and coral compounds using molecular dynamic simulation and docking methods
Background and purpose: Leishmaniasis is a parasitic disease prevalent in subtropical and tropical regions, with limited and often toxic treatments ineffective against drug-resistant strains. This study explored 1,013 compounds from algae and corals for potential anti-leishmanial effects…
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Artikel Jurnal
In silico discovery of CETP inhibitors from ZINC15 compounds using docking, ADMET filtering, and molecular dynamics simulations
Background and purpose: Cholesteryl ester transfer protein is a crucial regulator of lipid metabolism and is considered a promising target for treating atherosclerotic cardiovascular disease. Given the clinical limitations and adverse effects of previous cholesteryl ester transfer protein…
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Artikel Jurnal
Phenolic compounds from Diarthron lessertii: isolation, cytotoxicity, and interaction with cancer signaling pathway, FOXO3a
Background and purpose: Natural products are valuable sources of anticancer agents. This study investigated the phytochemical composition of Diarthron lessertii shoot extract and evaluated the anticancer potential of its isolated phenolic constituents. Experimental approach: Phenolic compounds were…
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Artikel Jurnal
Computational investigation for exploring botanical ingredients as potential negative allosteric modulators targeting metabotropic glutamate receptor 5
Background and purpose: Metabotropic glutamate receptors are class C G-protein-coupled receptors that respond to the neurotransmitter glutamate. In particular, metabotropic glutamate receptor 5 (mGluR5) has been a valuable drug target for the management of psychiatric and neurodegenerative…
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Artikel Jurnal
Pinostrobin pentanoate as a selective estrogen receptor-α antagonist in breast cancer: integrated in silico and in vitro evaluation
Background and purpose: Breast cancer remains the most commonly diagnosed cancer and the leading cause of cancer-related death among women worldwide. Estrogen receptor alpha (ERα) plays a major role in breast cancer cell proliferation, and approximately 70-80% of breast cancer cases are classified…
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Artikel Jurnal
Harmine reduces ROS-mediated hepatotoxicity in a cisplatin mouse model
Background and purpose: Cisplatin, a widely used anticancer agent, has adverse effects on normal tissues during cancer treatment. This study aimed to investigate the use of harmine, a plant β-carboline alkaloid, against pathways associated with ROS-induced apoptosis in the livers of mice…
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Artikel Jurnal
Ethyl acetate extract of Elephantopus mollis Kunth. induced apoptosis, senescence, and inhibited metastasis-associated traits of human lung cancer cells
Background and purpose: Elephantopus mollis Kunth. (EM) is an attractive candidate for cancer treatment research due to its long history of use in traditional cancer remedies. As lung cancer is the most widespread and among the most lethal carcinomas, we assessed the toxicity and anti-metastatic…
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Artikel Jurnal
mPFC hemorrhage induces hippocampal CA1 dendritic spine plasticity and attentional deficits in mice
Background and purpose: Damage to a specific brain region, in addition to its local effects, can influence brain function by inducing neuroplasticity in remote areas. This study hypothesized that hemorrhage of the medial prefrontal cortex (mPFC) is associated with deficits in shifting attention…
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Artikel Jurnal
Investigating the in vivo effects of the human adipose tissue-derived stem cell transplantation and bromelain in myelin regeneration
Background and purpose: Natural compounds combined with human adipose-derived stem cell (hADSCs) transplantation could be considered an effective treatment for multiple sclerosis (MS). In the present study, the effects of bromelain administration in combination with hADSCs transplantation were…
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Artikel Jurnal
IGFBP-3 enhances irinotecan efficacy in colorectal cancer via ROS-mediated apoptosis and β-catenin suppression
Background and purpose: Colorectal cancer, a leading cause of mortality, is treated with surgery early and irinotecan (IRI) chemotherapy in advanced stages. Insulin-like growth factor-binding protein 3 (IGFBP-3), regulated by p53, mediates tumor suppression and apoptosis. This study evaluates the…