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BMC Biology
Scopus
ISSN 1741-7007 · BMC · 2.968 artikel di indeks
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Artikel Jurnal
Absence of conserved immune signalling pathways and increased pathogen susceptibility associated to photosymbiosis in acoels
Abstract Background Host immunity plays an important role in coral symbiosis with dinoflagellates. Photosymbiosis (the association between hosts and photosynthetic endosymbionts) has evolved multiple times within animals, e.g. within acoels, which are soft-bodied marine invertebrates whose immunity…
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Artikel Jurnal
Reduced prediction updating shapes serial dependence in autistic traits
Abstract Background Serial dependence, the influence of prior experience on current perception or decision, has typically been studied in static, perceptual contexts. Here, we investigate whether serial dependence reflects not just passive carryover but feedback-based updating of internal models…
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Artikel Jurnal
Parental fasting effects on offspring immune gene expression, epigenetic patterns, and gut microbiota in a species with male pregnancy (Syngnathus typhle)
Abstract Background Intermittent fasting is widely promoted for its potential to improve health and extend lifespan, yet these benefits may come at a reproductive cost, potentially reducing parental fitness and offspring quality. While the inter- and transgenerational effects of fasting are…
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Artikel Jurnal
Butterfly brains change in morphology and in gene splicing patterns after brief pheromone exposure
Abstract How insect brains differ between the sexes and respond to sex-specific pheromones is still not well understood. Here we briefly exposed female Bicyclus anynana butterflies to wild type and modified male sex pheromone blends, previously shown to modify females’ sexual preferences, and…
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Artikel Jurnal
The first RNA viruses detected in a trypanosome
Abstract Background Trypanosomatids are parasitic flagellates best known for human pathogens causing sleeping sickness, Chagas disease, and leishmaniasis. RNA viruses infecting these protists have recently gained attention for their role in disease severity. While numerous such viruses have been…
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Artikel Jurnal
Increased prolactin levels in pregnancy affect colorectal cancer aggressiveness
Abstract Background Colorectal cancer (CRC) is diagnosed during approximately 1 in 13,000 pregnancies and is associated with worse outcomes, including a higher incidence of metastatic disease at diagnosis and reduced maternal survival compared to non-pregnant patients. In this study, we…
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Artikel Jurnal
Transposable element dynamics in Arthropoda genomes and their impacts on the evolution of functional genes
Abstract Background Transposable elements (TEs) are critical in shaping genomic architecture and evolutionary processes, driving genome size expansion and functional innovation. TE dynamics and their contribution to genome expansions have been reported extensively; yet, there is a gap in…
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Artikel Jurnal
Long-read sequencing reveals increased isoform diversity in key transcription factor effectors of intercellular signalling at the invertebrate-vertebrate transition
Abstract Background Several intercellular signalling pathways (including wingless (Wnt), hedgehog (Hh), and bone morphogenetic protein (BMP)) are used repeatedly in animals throughout development and evolution and are also frequent targets for disease-associated disruptions. We have previously…
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Artikel Jurnal
IbinA and IbinB regulate the Toll pathway-mediated immune response in Drosophila melanogaster
Abstract Background To combat infection, an immune system needs to be promptly activated but tightly controlled to avoid destruction of host tissues. IbinA and IbinB are related short peptides with robust expression upon microbial challenge in Drosophila melanogaster. Results Ibin genes are…
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Artikel Jurnal
Proteomics analysis of human mesenchymal stromal/stem cell sarcomagenesis model identifies ALDH1A3 and CD99 as potential targets in the transformation process
Abstract Background Mesenchymal stromal/stem cells (MSC) may represent the cell-of-origin for sarcoma development. A collection of human MSCs sequentially mutated with an increasing number of oncogenic hits served to recreate a step-wise process of sarcomagenesis. To identify potential protein…
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Artikel Jurnal
Remodeling of the cell membrane-associated protein pool affects adhesive membrane properties in filaggrin insufficient keratinocytes and impacts distinct cellular and organellar functions
Abstract Background Atopic dermatitis (AD) is a highly prevalent inflammatory skin disease, affecting up to 30% of children at some point in their life and frequently persisting into adulthood. Insufficiency in the late epidermal protein filaggrin is frequently observed in the lesional skin of…
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Artikel Jurnal
The key role of cheaters in the persistence of cooperation
Abstract Background Evolution of cooperation is a major, extensively studied problem in evolutionary biology. Cooperation is beneficial for a population as a whole but costly for the bearers of social traits such that cheaters enjoy a selective advantage over cooperators. Here, we focus on…
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Artikel Jurnal
Tryptophan catabolism reprograms immunity to prevent hemolymph bacterial dysbiosis and support molting in Spätzle-deficient Helicoverpa armigera larvae
Abstract Background Molting is a critical yet vulnerable stage in insect development, during which the peritrophic matrix is temporarily disrupted. This transient loss of gut barrier integrity can allow gut bacteria to escape into the hemocoel, where they may proliferate in the nutrient-rich…
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Artikel Jurnal
BRD4-mediated transcriptional activation of PDLIM4 enhances p21 stability and chemosensitivity in lung adenocarcinoma independent of p53
Abstract Background Understanding p53-independent regulatory mechanisms is crucial for predicting outcomes in lung adenocarcinoma (LUAD) and developing improved therapeutic strategies. Results We found that PDLIM4 is highly expressed in LUAD tumor tissues, where it induces G2/M phase cell cycle…
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Artikel Jurnal
Shaping with water: linking moisture perception to development in plant roots
Abstract Water is the most limiting resource for plant growth and development. Heterogeneity in the environmental distribution of water requires plants to direct root growth toward water and to avoid investing resources in areas that lack water. Roots use hydrosignaling pathways—hydrotropism…
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Artikel Jurnal
Cyclohexyl acetate functions like a volatile sex pheromone mimic in Caenorhabditis nematodes
Abstract Background Nematodes communicate via diverse sex pheromones, including long-range volatile signals, short-range chemical cues, and contact-dependent molecules. While the ascaroside family of small molecules that mediate short-range attraction is well characterized, the identities and roles…
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Artikel Jurnal
Major transitions in early coral development: novel insights enabled by visualisation of a comprehensive transcriptomic dataset for Acropora millepora
Abstract Background Given the ecological importance of reef-building corals (Scleractinia), it is perhaps surprising that the molecular mechanisms underlying many of the morphological and metabolic changes during their development remain unclear. In part, this is due to the lack of a comprehensive…
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Artikel Jurnal
Dragon Kill Points: applying a transparent working template to relieve authorship stress
Abstract Classifying and ranking academic authorship lists is complex in practice, despite existing frameworks, and can lead to conflict. We propose Dragon Kill Points, adapted from multiplayer gaming, to track contributions throughout a project’s lifecycle. Dragon Kill Points is based on five…
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Artikel Jurnal
METTL16-m6A-PGC-1α axis contributes to exercise-induced mitochondrial adaptations in skeletal muscle of high-fat diet-fed insulin-resistant mice
Abstract Background The dynamic change of N6-methyladenosine (m6A) modification on substrate RNA molecules plays a critical role in different biological processes and disease pathogenesis. Although the beneficial effects of exercise training (ET) on skeletal muscle insulin resistance (IR) are…
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Artikel Jurnal
TPST2-mediated tyrosine sulfation orchestrates porcine preimplantation development
Abstract Background Tyrosine sulfation is a widespread posttranslational modification in mammals and is known to influence protein function and signaling. However, its functional significance during porcine preimplantation development remains poorly understood. Results In this study, we demonstrate…
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