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BMC Medicine
Scopus
ISSN 1741-7015 · BMC · 4.898 artikel di indeks
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Artikel Jurnal
Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study
Abstract Background Observational studies link high blood pressure in pregnancy to numerous adverse pregnancy and perinatal outcomes; however, findings may be affected by residual confounding or reverse causation. This study aimed to assess the causal effect of blood pressure during pregnancy on a…
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Artikel Jurnal
Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa
Abstract Background Immune responses after SARS-CoV-2 infection remain poorly characterized in African populations, despite widespread viral transmission and proportionally lower COVID-19 severity and mortality than in other regions. We aimed to define the determinants and durability of humoral and…
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Artikel Jurnal
Prevalence of use and interest in using glucagon-like peptide-1 receptor agonists for weight loss: a population study in Great Britain
Abstract Background This study aimed to assess the prevalence of glucagon-like peptide-1 (GLP-1) receptor agonist use and interest in using medications for weight loss among adults (≥ 18 years) in Great Britain. Methods Nationally representative household survey, January–March 2025 (n = 5893)…
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Artikel Jurnal
Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma
Abstract Background Cholangiocarcinoma (CCA) remains a highly lethal malignancy with a dismal prognosis, primarily driven by therapeutic resistance. A dominant resistance mechanism involves overexpression of anti-apoptotic BCL-2 proteins (BCL-XL, BCL-2, MCL-1). While direct inhibition of these…
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Artikel Jurnal
Disproportionate climate burden of rising temperatures on low birth weight in Pakistan
Abstract Background Warming temperatures add to the global health burden, with disproportionate effects on pregnant women and newborns. Low birth weight is a major neonatal health issue in Pakistan, leading to neonatal mortality and impaired long-term health. We assessed the impact of extreme…
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Artikel Jurnal
Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy
Abstract Background Cytotoxic T-cell-mediated tumor lysis is a key mechanism of oncolytic virotherapy. While oncolytic viruses expressing bispecific T-cell engagers (BiTE) enhance tumor targeting, they lack costimulatory signals, leading to T-cell exhaustion. We developed an oncolytic adenovirus…
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Artikel Jurnal
CardioMetAge estimates cardiometabolic aging and predicts disease outcomes
Abstract Background Existing aging clocks, designed to quantify biological aging, primarily capture systemic changes and may overlook alterations crucial for cardiometabolic diseases (CMDs). Methods In this study, we developed the CardioMetAge model, an aging clock tailored to predict CMD-related…
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Artikel Jurnal
Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4
Abstract Background Hypertension (HTN) has been linked to changes in DNA methylation. However, longitudinal epigenome-wide analyses are still limited. Methods We analyzed data from the KORA F4 and FF4 studies, conducted approximately 7 years apart. The dataset included 2614 participants, each with…
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Artikel Jurnal
Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis
Abstract Background Psychoactive substance use (PSU) and cancer are frequently observed comorbidities that have reciprocal influences and shared behavioral traits of the affected patients. While, e.g., nicotine and alcohol are major carcinogens in the etiology of lung and head and neck cancers…
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Artikel Jurnal
Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children
Abstract Background Approximately half of the epilepsy cases lack a documented cause. Despite growing evidence linking maternal diabetes to pregnancy complications and impaired child neurodevelopment, little is known about its potential association with child epilepsy. This study aims to determine…
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Artikel Jurnal
How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project
Abstract Background It remains unclear whether reengaging in lifestyle weight loss interventions is effective for the long-term. Methods We conducted the CENTRAL (trial 1, T1) lifestyle weight-loss trial in 2012–2014, and the DIRECT-PLUS (trial 2, T2) weight-loss trial in 2017–2018. All…
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Artikel Jurnal
ADHD and adherence to antihypertensive medication treatment: a multinational cohort study
Abstract Background Adherence to antihypertensive medication, alongside lifestyle modifications, is fundamental to managing hypertension and reducing the risk of cardiovascular disease. Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder associated with a range…
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Artikel Jurnal
Patient-centred postpartum care provision: virtual delivery, tiered escalation, and tensions between efficiency, preference, and clinical concern
Abstract Background Good quality postnatal care is of key importance for maternal and infant health. During the pandemic, healthcare services were reconfigured with increased virtual delivery, reducing infection transmission risk for pregnant women, new mothers, newborn babies, and healthcare…
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Artikel Jurnal
Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis
Abstract Background Neurological sequelae from acute meningitis are estimated to affect more than 30% of survivors worldwide, though often underreported or undetected due to inadequate follow-up, limited access to healthcare services, and diagnostic challenges. The aim of this systematic review and…
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Artikel Jurnal
Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilities
Abstract Background Older adults (> 65 years) residing in long-term care facilities (LTCFs) are at elevated risk of severe outcomes from respiratory infections. Infections often remain undetected or present atypically in this population, leading to underdiagnosis. Our study aimed to estimate the…
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Artikel Jurnal
Time for change in implementation research and practice
Abstract Background We argue implementation research pays insufficient attention to time. We were prompted by learning gained from the Harnessing Innovation in Global Health for Quality Care (HIGH-Q) programme to explore implementation through time as an analytical lens. Time directly underpins how…
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Artikel Jurnal
Association of parental education with offspring psychiatric diagnoses, violent crimes, and suicidal behavior: a nationwide Swedish quasi-experimental study
Abstract Background Higher parental educational attainment is associated with a reduced risk of mental health problems in offspring. However, these associations might partially reflect unmeasured confounding rather than causal effects. Aims To investigate the association between parental education…
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Artikel Jurnal
Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel
Abstract Background Spontaneous preterm birth (sPTB) remains a major contributor to neonatal morbidity and mortality, with limited reliable early prediction tools. Existing biomarkers, such as the insulin-like growth factor-binding protein 4 (IBP4) to sex hormone-binding globulin (SHBG) ratio…
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Artikel Jurnal
Social networking site use, depressive and anxiety symptoms in adolescents: evidence from a longitudinal cohort study (SCAMP)
Abstract Background The growing and pervasive use of social network sites (SNS) has raised concerns about their impact on adolescent mental health during this sensitive developmental phase. Existing longitudinal studies are constrained by methodological limitations and limited exploration of…
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Artikel Jurnal
ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics
Abstract Background Cancer stem cells (CSCs) play a crucial role in breast cancer (BRCA) progression and lymph node metastasis. This study aimed to elucidate how CSCs reshape the immune microenvironment during metastatic dissemination, with a particular focus on macrophage and T-cell regulation…
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