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Immunity & Ageing
Scopus
ISSN 1742-4933 · BMC · 634 artikel di indeks
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Artikel Jurnal
Exercise-induced changes in circulatory aging-related biomarkers among older adults: longitudinal analysis of a multi-stage randomized clinical trial
Abstract Background Long-term trials evaluating exercise’s impact on systemic aging biomarker profiles in older populations remain limited, particularly regarding multi-component exercise (MCE)-the modality prioritized in the WHO’s 2020 physical activity guidelines. Methods The original study…
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Artikel Jurnal
Impaired function of Vγ9Vδ2 T cells in frail elderly
Abstract Background Frailty, a geriatric syndrome of multisystem physiological decline, elevates vulnerability to adverse health outcomes and involves immunosenescence. While T cell dysfunction is implicated, alterations in the major circulating γδ T cell subset, Vγ9Vδ2 T cells, remain largely…
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Artikel Jurnal
Physical frailty in relation to immunosenescence involving pDC function in the Japanese elderly: a cross-sectional survey study
Abstract Background Physical frailty leads to a decline in both immune function and physical function, which can lead to a worsening of infections in the elderly; however, the mechanisms have not been fully elucidated. This observational study investigated and clarified the relationship between…
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Artikel Jurnal
Age-dependent patterns of inflammatory and autoimmune markers: CRP-RF correlation emerges after age 50 in asymptomatic adults
Abstract Background Inflammatory markers are widely used clinically, yet their age-dependent interrelationships remain incompletely characterized. This study analyzed 5,218 adults (mean age 43.7 ± 15.2 years, 66.8% female) with elevated C-reactive protein (CRP > 10 mg/L) to investigate correlations…
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Artikel Jurnal
Respiratory virus immune response in the aged host
Abstract Viruses are a major cause of acute respiratory illness in older adults and pose a substantial burden as the elderly population continues to grow. In the current COVID-19 global health crisis, achieving a better understanding of the aging immune system proves to be an imperative step in…
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Artikel Jurnal
Kaempferol alleviates T-cell immunosenescence and inflammaging in aged mice via the SIRT3-LKB1-AMPK-mitophagy pathway
Abstract Background Immunosenescence, characterized by progressive immune dysfunction accompanied by chronic low-grade inflammation (inflammaging), is a key driver of systemic ageing. Senescent T cells are central to this process, yet effective interventions remain limited. Kaempferol is a natural…
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Artikel Jurnal
Acute viral respiratory infections are not associated with an increased IMMune Age indeX (IMMAX) four weeks after infection: a prospective observational cohort study
Abstract Background The factors that determine how quickly immunosenescence occurs in individuals are not yet fully understood. Viral infections throughout one’s life span are suggested to be a relevant modulator. Latent chronic infections, such as CMV or EBV, occupy immune space and are associated…
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Artikel Jurnal
Longitudinal humoral and memory B-cell responses to repeated SARS-CoV-2 vaccination in long-term care facilities residents
Abstract Background Long-term care facility (LTCF) residents represent one of the populations most vulnerable to SARS-CoV-2 infection and have experienced repeated vaccination and natural viral exposure since the beginning of the COVID-19 pandemic. The long-term dynamics of humoral and cellular…
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Artikel Jurnal
Advances in skin aging: integrating epigenetic, cellular, and immune mechanisms for targeted therapy
Abstract As the largest and most externally exposed organ, the skin is particularly vulnerable to aging, rendering skin aging a widespread clinical and aesthetic concern. Driven by both intrinsic and extrinsic factors, skin aging is characterized by progressive functional decline and structural…
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Artikel Jurnal
Aging-related immune phenotypes are associated with subclinical coronary atherosclerosis in a middle-aged population: a subcohort of the Swedish CArdioPulmonary bioImage Study
Abstract Aging-related immune perturbations, including lower proportions of regulatory T (Treg) cells, shifts in naïve/memory T cells, and elevated monocyte and neutrophil counts, are well documented in patients with manifest coronary artery disease (CAD). In a cross-sectional study, we…
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Artikel Jurnal
Inflammaging and the role of micronutrients as immunomodulators: a pathway to healthy aging
Abstract Background Healthy aging is increasingly challenged by inflammaging, a chronic, low‑grade inflammatory state primarily exacerbated by gut microbiota dysbiosis and declining immune function. Persistent digestive and systemic inflammation, along with immunosenescence, contributes to multiple…
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Artikel Jurnal
Age-associated B cells, key players in autoimmune pathogenesis
Abstract Age-associated B cells (ABC) are a unique subset of antigen-experienced B cells that were first identified in old female mice. ABC have both physiological and pathological roles in humans and they are important in the progression of some immune disorders, chronic infections, and even in…
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Artikel Jurnal
Immunoinflammatory biomarkers for sepsis-associated acute kidney injury: a multicenter prospective cohort study
Abstract Background Immune dysregulation is central to sepsis-related organ injury, yet standard clinical indicators show limited predictive value for sepsis-associated acute kidney injury (SA-AKI) in older adults(aged ≥ 65 years). This study evaluated whether immuno-inflammatory biomarkers improve…
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Artikel Jurnal
Toll-like receptor 2 modulates age-associated insulitis and fibrotic remodeling of Langerhans islets
Abstract Background The steadily increasing aging population highlights the importance of maintaining health at an advanced age. Metabolic diseases are among the most prevalent age-related disorders, and the Langerhans islets, critical regulators of glucose homeostasis, are particularly susceptible…
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Artikel Jurnal
An immune-associated mitochondrial DNA variant with sex differences reveals a putative novel microprotein called MASL
Abstract The use of mitochondrial wide association studies (MiWAS) to link mitochondrial DNA variants (mtSNPs) to phenotypes of interest has uncovered important connections between mitochondrial genes and human health. The recent introduction of a re-annotated mitochondrial genome that accounts for…
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Artikel Jurnal
Age- and sex-dependent heterogeneity during LPS-induced murine acute lung injury
Abstract Acute respiratory distress syndrome (ARDS) remains difficult to treat due to its heterogeneous etiology. In this study, a mouse model of intratracheal lipopolysaccharide (LPS) instillation was used to investigate age- and sex-dependent immune responses. After six hours of LPS exposure and…
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Artikel Jurnal
CD8+ effector memory and regulatory T cell dynamics predict subclinical atherosclerotic plaque formation in healthy aging
Abstract Background Subclinical atherosclerotic plaque (SAP) develops silently in older adults. Biological changes that predict plaque formation are not well defined. We examined whether circulating immunological, metabolic, and functional measures identify vascular vulnerability before clinical…
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Artikel Jurnal
IL-35 promotes synovial fibroblast senescence via activation of cGAS-STING-TBK1-IRF3 pathway in rheumatoid arthritis
Abstract Interleukin-35 (IL-35) exerts immunosuppressive effects in rheumatoid arthritis (RA), but its direct impact on synovial fibroblasts (SFs) remains unclear. This study aimed to redefine the role of IL-35 in RA by uncovering its therapeutic mechanism through the induction of STING-dependent…
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Artikel Jurnal
Immune risk phenotype and long-term mortality after community-acquired pneumonia in older adults: clinical and immune determinants
Abstract Background Community-acquired pneumonia (CAP) has been associated with poor long-term outcomes in older adults. In most pre-pandemic studies, long-term mortality was assessed with a focus on comorbidity burden. Although immunosenescence is a key determinant of CAP, post-acute immune…
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Artikel Jurnal
Insights into the heterogeneity of pneumococcal polysaccharide vaccine immunogenicity in older adults
Abstract Background Older adults are at increased risk of pneumonia and invasive pneumococcal disease, yet vaccine-induced immunity varies substantially within this population. We evaluated antibody responses to the 23-valent pneumococcal polysaccharide vaccine (PPV23) in 188 Dutch adults aged…