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Particle and Fibre Toxicology
Scopus
ISSN 1743-8977 · BMC · 737 articles in the index
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Journal Article
Inhalation toxicity, pulmonary clearance, and biotransformation of ferric oxide nanoparticles in rats
Abstract Background Ferric oxide (Fe2O3) nanoparticles are widely used in industrial and biomedical applications, raising concerns regarding inhalation exposure, particularly in occupational settings. Although the inhalation toxicity of magnetite (Fe3O4) was reported, no studies have addressed the…
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Journal Article
Particulate matter 2.5 promotes bladder cancer cell migration and invasion through the crosstalk between integrin-mediated MAPK/ERK and Wnt/β-catenin pathways
Abstract Background Fine particulate matter 2.5 (PM2.5), a key indicator of air pollution, is classified as a human carcinogen. However, the link between air pollution and bladder cancer (BC) progression remains unclear. Dysregulation of the Wingless-related integration site (Wnt)/β-catenin and…
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Journal Article
Modulatory effects of CeO2 nanoparticles on bleomycin-induced active pulmonary disease processes in animal and human airway epithelium models
Abstract Background Understanding the impacts of inhaled insoluble nanomaterials as they are encountered in the environment and workplace, in injured lungs remains limited, particularly with respect to their role in the progression or mitigation of lung pathology. While some studies suggest…
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Journal Article
Lung retention, distribution and persistence of polymer particles in rats exposed via inhalation
Abstract Background Microplastics have been repeatedly detected in the human body, yet uncertainties surround their bioavailability and fate due to experimental challenges and limitations, especially regarding their nano-sized counterparts. Knowing that toxicokinetics information is essential for…
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Journal Article
Supplemental exposure to polystyrene nanoplastics synergistically amplifies calcium oxalate crystal–induced injury to renal tubular epithelium, accelerating the formation of calcium oxalate kidney stones
Abstract Background With the escalating issue of polystyrene microplastic pollution, microplastic particles have been detected in human urine. While calcium oxalate (CaOx) crystals are well-established mediators of renal stone formation, the role of microplastics, particularly polystyrene…
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Journal Article
Impact of carbon-based fibers morphologies on their carcinogenic potential
Abstract Background Carbon based fibers are considered to exhibit a carcinogenic potency when inhaled into the deep lung. Mesotheliomas develop after intraperitoneal application of multi-walled carbon nanotubes (MWCNTs) exceeding a diameter of about 37 nm, whereas carcinogenic potency decreases for…
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Journal Article
Susceptibility to systemic autoimmunity rather than the presence of the HLA-DR4 peptide binding domain alone leads to severe inflammatory arthritis following inhalation of crystalline silica
Abstract Background The mucosal origins hypothesis of rheumatoid arthritis (RA) posits that inhalant exposures, such as cigarette smoke and crystalline silica (c-silica), trigger immune responses in the lungs that contribute to joint disease onset. However, the relationship between inhalants, lung…
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Journal Article
A quantitative definition for poorly soluble particles
Abstract Poorly soluble low toxicity particles (PSLT) have long been a concept in particle toxicology and regulatory frameworks addressing inhalation hazards. The term PSLT refers to particles that exhibit low toxicity and minimal solubility in biological fluids, leading to prolonged retention in…
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Journal Article
A comparative biodistribution and toxicity study of single and multi-component nanomaterials: NMs: TiO2, SiC, and SiC@TiO2
Abstract Background With the increasing integration of nanomaterials (NMs) into daily life, their technological advantages have become evident. However, their intricate interactions with biological systems introduce complexities that can lead to unpredictable toxicological outcomes. This study…
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Journal Article
Gut-ovary axis mediated synergistic reproductive toxicity of polystyrene nanoplastics and perfluorobutanoic acid co-exposure: pyroptotic signaling and probiotic mitigation
Abstract Polystyrene nanoplastics (PS-NPLs) and perfluorobutanoic acid (PFBA) are pervasive contaminants of great concern and can enter human body primarily through gastrointestinal tract. However, their single and combined effects on female reproductive health remain poorly explored. In this…
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Journal Article
Alignment of in vitro and in vivo pulmonary inflammation models using crystalline quartz silica
Abstract Background Systematic in vitro–in vivo comparisons are increasingly used to assess the relevance and predictivity of in vitro lung models for inhalation toxicology and regulatory risk assessment. Here, we compared inflammatory endpoints across established in vitro and in vivo pulmonary…
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Journal Article
Oxidative aging facilitates biological barrier penetration of polyethylene microplastics, amplifying systemic lipotoxicity in aquatic species
Abstract Background Environmental aging processes, such as oxidation, can substantially modify the physicochemical properties and toxicity of microplastics (MPs). Nevertheless, most studies have focused on pristine MPs, overlooking aged forms that more accurately represent environmental exposure…
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Journal Article
Repeated air pollution exposure predisposes to adverse outcomes from acute lung injury
Abstract Background Air pollution exposure is associated with increased risk of developing acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). While the possibility of air pollution priming the immune system to exacerbate ALI is postulated, it lacks experimental evidence…
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Journal Article
Pulmonary toxicity of micro- and nano polyethylene particles following intratracheal instillation in rats
Abstract Background Micro- and nano-sized polyethylene plastics (PE-MPs and PE-NPs) are emerging as potential risk factors for pulmonary disease and risk assessment. Currently, their is no direct evidence suggests this appreciable health risk extends to humans. Furthermore, the toxicological…
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Journal Article
Targeting the PPAR-γ-ABC transporter axis ameliorates secondary pulmonary alveolar proteinosis induced by indium oxide nanoparticles
Abstract Background Pulmonary alveolar proteinosis (PAP) is a rare lung disease with primary (usually autoimmune) and secondary forms. Unlike the autoimmune type, which can be treated with cytokine therapy or whole-lung lavage, the secondary form associated with occupational particulate exposure…
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Journal Article
Cu(OH)2 nanopesticide triggered heart failure-like pathogenesis in mice by potentially targeting mmu-miRNA-590-3p and mmu-miRNA-338-5p in Wnt/β-catenin signaling
Abstract Background Nanopesticides have been progressively incorporated into contemporary agricultural systems owing to their distinctive physicochemical characteristics and superior pest management capabilities. Given their environmental persistence and propensity for bioaccumulation…
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Journal Article
Polystyrene microplastics and hepatic fibrosis-related indices in type 2 diabetes: a cross-sectional analysis with experimental validation
Abstract Background Microplastics (MPs) are emerging environmental contaminants with potential hepatotoxicity, yet direct epidemiological evidence linking internal MP exposure to liver injury is scarce, particularly in individuals with type 2 diabetes (T2D). In this cross-sectional study nested…
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Journal Article
Ultraviolet irradiation-induced enhancement of inflammatory potential of polystyrene nano- and microplastics and effects of dispersion on lung clearance
Abstract Background Microplastics are pervasive environmental pollutants that pose potential risks to human health, particularly through inhalation. Despite growing concerns, limited data exist on how environmental aging, such as ultraviolet (UV) irradiation, affects the pulmonary toxicity of…
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Journal Article
Epithelial NLRP3 drives silica-induced lung injury and fibrosis through IL-18 and pro-fibrotic neutrophil recruitment
Abstract Background Silicosis is a progressive inflammatory and fibrotic lung disease with no effective treatments beyond symptom management. While global NLRP3 inflammasome deficiency attenuates silica-induced pathology, myeloid-specific Nlrp3 deletion provides no protection, suggesting that other…
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Journal Article
Perinatal exposure to nano-polystyrene: deleterious imprinting on inflammatory bowel diseases
Abstract Background The extent of production and use of plastics leads to release of nanoplastics (NPL) into the environment, where they undergo weathering that could alter their toxicological properties. NPL enter the human food chain via contaminated food, and food packaging, and within the body…