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Pharmaceutical Biology
Scopus
ISSN 1744-5116 · Taylor & Francis Group · 1.310 artikel di indeks
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Artikel Jurnal
Triptolide in renal disorders: dual roles of therapeutic potential and nephrotoxicity: a narrative review
Background Triptolide (TP), derived from Tripterygium wilfordii, exhibits anti-inflammatory, immunosuppressive, and antifibrotic properties with potential for treating renal diseases, but its clinical use is restricted by dose-dependent nephrotoxicity.Objective The aim of this review is to…
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Artikel Jurnal
Jianpi Zishen Decoction ameliorates renal damage induced by systemic lupus erythematosus through inhibition of the TLR4/MAPK pathway
Context Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems. Jianpi Zishen Decoction (JZD) is a TCM formula used to improve proteinuria in SLE, which has been widely used in the treatment of renal damage in SLE.Objective To investigate the potential targets and…
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Artikel Jurnal
Cyanoglycosides isolated from Moringa oleifera seeds inhibited PFKFB3/TGF-β1/smads pathway to alleviate diabetic nephropathy through driving metabolic reprogramming
Context Diabetic nephropathy (DN) is a major complication of diabetes. Moringa oleifera seeds are recognized as a source of bioactive compounds with potential health benefits, prompting investigation into their specific components and effects on DN.Objective This study aimed to isolate bioactive…
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Artikel Jurnal
(±)-Rutacycoumarins A and B: two pairs of unprecedented coumarin enantiomers from the aerial part of Ruta graveolens L. and chemically synthesized
Context Benzofuran derivatives are important structural motifs found in natural products, often exhibiting significant biological activities. Ruta graveolens L. is a plant source known for containing diverse bioactive compounds.Objective This study aimed to isolate and characterize compounds from…
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Artikel Jurnal
Graveoumarins A–C: chiral resolution, absolute configuration, and anticoagulant/anti-inflammatory activities of 3′-methyl-3′-butenyl coumarins from ruta graveolens L
Context Several coumarins have been isolated from Ruta graveolens L., but the chirality of many remains uncharacterized or their absolute configurations unresolved.Objective This study aimed to comprehensively separate and characterize the chirality of 3′-methyl-3′-butenylcoumarins from R…
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Artikel Jurnal
Turmeric (curcuma longa) rhizome essential oil: analytical profile of authenticated and commercial samples, safety and pharmacology review
Context Turmeric (Curcuma longa) rhizome essential oil is the volatile and aromatic fraction of turmeric rhizome. Despite increasing commercial availability and scientific interest, variability in production practices and oil composition has created challenges for quality, safety, and…
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Artikel Jurnal
Mechanistic insight into the anti-inflammatory and lung-protective effects of Agrimonia pilosa extract via NF-κB/MAPK inhibition in ovalbumin- and lipopolysaccharide-induced respiratory inflammation models
Context Asthma and COPD involve airway inflammation, oxidative stress, and epithelial cell apoptosis. While corticosteroids are common, long-term use can cause adverse effects, prompting interest in plant-based anti-inflammatory alternatives. Agrimonia pilosa (AP) shows promise, but its…
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Artikel Jurnal
Comparative analysis of in vitro immunomodulatory potential of four Gentiana species
Context Among Gentiana species present in the Balkan Peninsula, eight are used in traditional medicine mainly for the treatment of gastrointestinal disorders, but other applications have also been recorded, including improving the immune system and health maintenance.Objective To examine the…
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Artikel Jurnal
Comparative cardioprotective effects of Kuanxiong Aerosol and its individual components in a rat model of acute myocardial infarction
Context Kuanxiong Aerosol (KXA), composed of volatile oils from sandalwood (Santalum album L.), galangal (Alpiniae Officinarum Rhizoma), asarum (Asari Radix), pepper (Piper longum L.), and borneol, is used to treat cardiovascular conditions. However, its scientific basis and the contribution of its…
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Artikel Jurnal
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes
Context Osteoarthritis is a chronic degenerative disease characterized by metabolic dysregulation, inflammation, and oxidative stress. MALAT1 plays a key role in OA pathogenesis. Pae exhibits anti-inflammatory activity, but its regulatory role in cholesterol-oxidative stress-iron metabolism in…
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Artikel Jurnal
Formulation-dependent dissolution and bioaccessibility of curcuminoids and (S)-ar-turmerone from eight commercial turmeric extract- and curcumin-containing dietary supplements
Context Curcumin-containing dietary supplements are widely marketed with claims of enhanced bioavailability, despite well-recognized limitations related to poor aqueous solubility, chemical instability, and extensive first-pass metabolism. Comparisons among commercially available products using…
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Artikel Jurnal
Total flavonoids of Abelmoschus manihot (L.) medic attenuate early renal injury in diabetic kidney disease by modulating the LINC00665/miR-379-5p axis
Context: Huangkui capsule (HKC), derived from Abelmoschus manihot (L.) Medic, is clinically utilized for diabetic kidney disease (DKD) treatment. Its primary bioactive components are the total flavonoids of A. manihot (L.) (TFA). Evidence has implicated the negative interaction between long…
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Artikel Jurnal
Harnessing nature: a systematic exploration of in vitro antileishmanial and antihuman African trypanosomal properties in traditional medicinal plants and their active principles
Context Current treatments for leishmaniasis and Human African Trypanosomiasis (HAT) are constrained by toxicity, high costs, and the growing threat of parasite resistance. In this context, natural products have emerged as promising alternatives, offering the potential for safer and more…
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Artikel Jurnal
Phytochemical study of Homalanthus giganteus: isolation, antiproliferative activity, and computational mechanistic insights of tigliane diterpenes against colorectal cancer
Context Colorectal cancer is the third most common and second deadliest cancer worldwide. Late diagnosis, poor outcomes in metastatic cases, and multidrug resistance emphasize the need for new therapies.Objective This study aimed to isolate bioactive compounds from Homalanthus giganteus Zoll. ex…
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Artikel Jurnal
Zexie decoction alleviates hyperlipidemia through modulation of the PPAR signaling pathway and lysophospholipid metabolism
Context Zexie Decoction (ZXD) is a classical traditional Chinese medicine prescription that has long been used for the treatment of hyperlipidemia. However, its material basis and underlying mechanisms remain unclear.Objective This research aims to explore the effective compounds and lipid-lowering…
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Artikel Jurnal
Lavandula angustifolia as a dual pharmacological system: from essential oil to polyphenol-rich biomass
Context Lavandula angustifolia Mill. is a widely used medicinal and aromatic plant with well-documented pharmacological activity, primarily attributed to its essential oil. However, the contribution of nonvolatile constituents and post-distillation biomass remains insufficiently characterized…
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Artikel Jurnal
CB001 bioactive compounds mitigate intestinal immune dysregulation induced by simulated microgravity and radiation via B cells modulation
Background Gastrointestinal discomfort is a prevalent issue during spaceflight, yet targeted therapeutic strategies remain elusive. Existing research largely relies on single-factor modeling, limiting a comprehensive understanding of the underlying pathologies.Methods We established a composite…
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Artikel Jurnal
Natural products targeting hepatitis B virus X protein and HBx-associated pathways in HBV-related hepatocellular carcinoma: mechanisms and therapeutic potential
Context Hepatocellular carcinoma (HCC), largely driven by chronic hepatitis B virus (HBV) infection, remains a major global health challenge with limited curative options in advanced stages. The hepatitis B virus X protein (HBx) is a multifunctional viral oncoprotein that plays a central role in…
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Artikel Jurnal
A design of experiments approach to production of medicinal bioactives in Mitragyna speciosa (Korth.) Havil
Context Mitragyna speciosa (Korth.) commonly known as ‘kratom’ is a tropical tree native to southeast Asia, that produces psychoactive monoterpenoid indole alkaloids including mitragynine. Kratom products are growing in popularity for increasing energy, improving mood and alleviating minor pain…
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Artikel Jurnal
Chemical standardization of kava (Piper methysticum) extract using UHPLC-MS/MS and the method of standard addition
Background Kava (Piper methysticum G.Forst.) is used traditionally in the South Pacific for ceremonial and medicinal purposes and as a dietary supplement for its anxiolytic effects. The pharmacological activity of kava is attributed to kavalactones and flavokavains, including desmethoxyyangonin…
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