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Molecular Pain
Scopus
ISSN 1744-8069 · SAGE Publishing · 1,627 articles in the index
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Journal Article
Differential expression of µ-, δ-, and κ-opioid receptors in muscle afferents from male and female rats
Small diameter unmyelinated (group IV) and myelinated (group III) muscle afferents transmit action potentials to signal muscle pain and the exercise pressor reflex (EPR). The EPR helps to drive the cardiovascular response to exercise. µ- (µOR), δ- (δOR), and κ - (κOR) opioid receptors (OR) have…
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Journal Article
Electroacupuncture alleviates inflammatory pain through AMPK-autophagy signaling and suppression of iNOS and IL-1β in inflamed tissues
Electroacupuncture (EA) effectively alleviates inflammatory pain, yet its underlying mechanisms remain incompletely understood. Emerging evidence implicates AMP-activated protein kinase (AMPK) and autophagy in modulating inflammation, but whether they mediate EA’s analgesic action is unknown. This…
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Journal Article
CD200/CD200R1 activation alleviates central sensitization in chronic migraine via STAT6
Objective Chronic migraine (CM) is characterized by central sensitization (CS), in which microglial activation plays a key role. The neuron-glia communication axis CD200/CD200R1 is a critical immunomodulatory pathway. This study investigated whether and how CD200/CD200R1 signaling modulates CS in a…
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Journal Article
Copper chelator ammonium tetrathiomolybdate ameliorates the visceral hypersensitivity in dextran sulfate sodium-induced colitis mice
Background: Visceral hypersensitivity is a prevalent and debilitating symptom in inflammatory bowel disease (IBD), severely impairing quality of life. Although mechanisms remain incompletely understood, recent studies have reported abnormal copper metabolism and elevated serum copper in IBD…
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Journal Article
CYP gene variants show preliminary evidence of association with patient-reported outcomes in active-duty service members with chronic pain
Chronic pain is highly prevalent among active-duty service members (ADSMs) and contributes to substantial physical, psychological, and social burden. Genetic factors are recognized as central to pain susceptibility and treatment response. While few studies have examined the genes involved in…
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Journal Article
Arrow promotes nociceptive sensitivity in
Normal sensitivity of the Drosophila larval nociceptor requires the activity of the Wg/WNT signaling pathway. When the nociceptor expression of Wg/WNT co-receptor Arrow, Drosophila ortholog of LRP5/6, is impaired by RNA interference, the larva becomes significantly hyposensitive to noxious thermal…
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Journal Article
Mechanical needling and sterile water hydrodissection modulate nociception via extracellular matrix perturbation and ion channels
Background: Musculoskeletal disorders are increasingly recognized as conditions involving extracellular matrix dysregulation, characterized by fibrosis, calcification, fascial adhesions, and altered nociceptor signaling. These features highlight the role of mechanobiology in pain generation and…
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Journal Article
Olfactory ensheathing cell transplantation targets macrophage extracellular traps and NKCC1 to alleviate pain after spinal cord injury
Spinal cord injury (SCI) triggers neuropathic pain through inflammatory secondary injury. Olfactory ensheathing cells (OECs) hold therapeutic promise, but their pain-relieving mechanisms are unclear. This study investigated whether OEC transplantation alleviates pain by modulating macrophage…
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Journal Article
Dezocine alleviates cancer-induced bone pain and suppresses intraosseous tumor growth in renal cell carcinoma via the NAMPT/NAD+ axis
Bone metastasis–associated pain is a major cause of morbidity in advanced renal cell carcinoma (RCC), and effective therapies that concurrently mitigate pain and intraosseous tumor burden remain limited. Here, we evaluated dezocine as a potential dual-action agent and explored the involvement of…
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Journal Article
Combination of GABA-derived short peptides and pregabalin in neuropathic pain: In vivo and in silico evaluation
Neuropathic pain is a significant clinical issue due to the limited efficacy and adverse effects of existing therapies. This study evaluated the antinociceptive effects of the GABA-derived short peptides pyroglutamylGABA, pyroglutamylGABA ethyl ester, and pyroglutamyl diGABA in combination with…
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Journal Article
Whole-blood miRNA candidate prioritization for longitudinal pain change suggests synaptic and neuronal organization pathway involvement in early rheumatoid arthritis
Pain is a major clinical outcome in chronic inflammatory disease, yet molecular correlates of within-person pain change remain unclear and must be distinguished from inflammatory change. We used longitudinal whole-blood multi-omics data from the RA-MAP/TACERA early rheumatoid arthritis cohort to…
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Journal Article
Characterisation of neurotensin-expressing interneurons in the mouse spinal dorsal horn
The spinal dorsal horn contains numerous excitatory interneurons, which can be assigned to functional classes based on morphological, electrophysiological and neurochemical criteria. One population consists of neurons that express neurotensin, and these belong to a larger group defined by the…
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Journal Article
Intrathecal injection in MaFIA mouse model inflicts localized reduction of macrophage populations within the dorsal root ganglia
Macrophages represent an essential component of the innate immune system that regulates multiple nervous system functions. This is highlighted in previous research that identifies an important somatosensory role for macrophages in peripheral dorsal root ganglia (DRG). In several pre-clinical pain…
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Journal Article
Average pain over time, but not current pain, is associated with salivary secretory immunoglobulin a in chronic back pain: A cross-sectional study
Chronic pain is accompanied by widespread physiological dysregulation, yet the mucosal immune system has received little attention. Salivary secretory-immunoglobulin-A (S-IgA) is a non-invasive biomarker of mucosal immunity modulated by sustained stress and autonomic activity. This cross-sectional…
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Journal Article
Pharmacological inhibition of MKP-1 exacerbates central post-stroke pain and neuroinflammation in mice
Central post-stroke pain (CPSP) remains difficult to treat due to limited understanding of its underlying mechanisms. Emerging evidence implicates microglia-driven neuroinflammation in CPSP development. Mitogen-activated protein kinase phosphatase-1 (MKP-1) negatively regulates MAPK signaling and…
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Journal Article
Endoplasmic reticulum stress contributes to high-dose radiation-induced chronic mechanical and thermal neuropathic pain
Introduction Exposure to high doses of radiation can cause serious harm to human health and lead to long-term chronic pain. However, the mechanisms underlying pain caused by radiation overexposure remain largely unknown. Methods In this study, the double hind paws and tail of mice were exposed to…
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Journal Article
Resveratrol alleviates neuropathic pain after spinal cord injury by suppressing δ-catenin palmitoylation-mediated membrane accumulation of Nav1.6 in the spinal dorsal horn
Neuropathic pain is a severe adverse complication of spinal cord injury (SCI) for which effective therapies are currently lacking. Resveratrol, a natural phytoalexin found in many plants and fruits, has been shown to relieve chemotherapy- and nerve injury-induced neuropathic pain and to promote…
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Journal Article
Precursor signaling redefined: Proneurotrophin-3, not neurotrophin-3, in primary sensory neurons as an instigator in neuropathic pain
Neurotrophin-3 (NT3), one member of the nerve growth factor family of neurotrophins, is initially synthesized as a large precursor, termed proneurotrophin-3 (proNT3), which undergoes proteolytic cleavage to generate mature NT3. A growing body of evidence suggests that proNT3 and its mature form…
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