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Annals of General Psychiatry
Scopus
ISSN 1744-859X · BMC · 1.591 artikel di indeks
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Artikel Jurnal
Understanding individual and structural factors behind extensive care needs in personality disorders: an interpretative phenomenological analysis
Abstract Extensive care needs, including frequent hospitalizations and compulsory care, are common among individuals with personality disorders (PD), yet the outcomes of such interventions remain uncertain. This study aimed to explore patient perspectives on the individual and structural factors…
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Artikel Jurnal
Benzodiazepines at the crossroads: navigating therapeutic promise and perils of misuse
Abstract Benzodiazepines (BZDs) are a widely prescribed class of psychoactive drugs known for their rapid anxiolytic, anticonvulsant, and sedative effects. Introduced as safer alternatives to barbiturates, BZDs quickly gained popularity across clinical settings but have since become a subject of…
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Artikel Jurnal
Global prevalence of different levels of anxiety and stress symptoms in healthcare students: A meta-analysis and meta-regression
Abstract Background There are limited reviews to report the different levels of anxiety and stress symptoms among students studying nursing, pharmacy, and allied health. Objective To calculate the global prevalence of different levels of anxiety and stress symptoms among healthcare students and…
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Artikel Jurnal
The mediating role of insulin resistance in depression driving phenotypic age acceleration
Abstract Background Depression, characterized by significant psychological and physiological alterations, has been proved to tightly associate with insulin resistance (IR) and hallmarks of biological aging. Phenotypic Age Acceleration (PhenoAgeAccel), which quantifies the discrepancy between…
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Artikel Jurnal
Prevalence and associated risk factors of psychotic experiences in the general population during the COVID-19 pandemic: a systematic review and meta-analysis
Abstract Background COVID-19 is strongly associated with common mental disorders, but little is known about its association with psychotic experiences (PEs). Subclinical psychotic experiences, such as hallucinations and delusions, can precede psychotic disorders. This review sought to consolidate…
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Artikel Jurnal
Beyond inflammation and cholesterol: atherogenic index of plasma mediates the link between hsCRP/HDL-C ratio and depression in US adults NHANES 2015–2020
Abstract Background Dyslipidemia and inflammation play key roles in the pathophysiology of depression and are significantly associated with the plasma atherogenic index (AIP). However, a reliable biomarker for diagnosing depression remains elusive. The hsCRP/HDL-C ratio, combining C-reactive…
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Artikel Jurnal
Transforming treatment-resistant depression (TRD) care in the Gulf Cooperation Council (GCC) countries: a narrative review of emerging therapies, advancements, and implementation barriers
Abstract Background Treatment-resistant depression (TRD) remains a major clinical challenge worldwide and across the Gulf Cooperation Council (GCC) countries, where the burden of mental health disorders continues to rise. Conventional TRD therapies, including antidepressants, augmentation…
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Artikel Jurnal
Mechanisms and clinical potential of combined tDCS and virtual reality in psychiatric disorders: a systematic review
Abstract Background Transcranial direct current stimulation (tDCS) and virtual reality (VR) have emerged as promising non-invasive interventions in treating psychiatric disorders. Despite their individual efficacy in improving symptoms of various psychiatric conditions, the understanding of the…
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Artikel Jurnal
The prefrontal–striatal signatures of reduced model-based learning in depressed patients
Abstract Background Anhedonia is the core symptom of major depressive disorder (MDD). Accumulating evidence indicates that an imbalance between model-based (MB) and model-free (MF) reinforcement learning (RL) characterizes MDD, but the underlying neural substrates remain unclear. We examined…
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Artikel Jurnal
Perceived social support in mental disorder: insights from the SSQ-6 and its associations with sociodemographic characteristics, clinical features, and admission patterns in a tertiary psychiatric care unit
Abstract Objectives This study aims to evaluate perceived social support (SS) in inpatients with mental disorders, its association with sociodemographic and clinical characteristics, and its impact on hospitalization patterns, highlighting the importance of evaluating and enhancing SS. Methods This…
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Artikel Jurnal
Association between changes in sleep quality and serum pro-inflammatory cytokine levels in patients with major depressive disorder following duloxetine treatment
Abstract Objective Major depressive disorder (MDD) is accompanied by prominent physiological abnormalities, notably sleep disturbances and immune-inflammatory dysregulation. As a serotonin-norepinephrine reuptake inhibitor, antidepressant duloxetine exhibits both anti-inflammatory effects and…
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Artikel Jurnal
Associational pathway analyses of depression and impulsivity in the relationship between internet addiction and non-suicidal self-injury among adolescents: a cross-sectional case–control study
Abstract Background Adolescents undergo important developmental changes, characterized by profound biological and psychosocial changes. This period is also associated with increased vulnerability to mental health challenges and engagement in risky/problematic behaviors. Non-suicidal self-injury…
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Artikel Jurnal
Normative modeling reveals functional connectivity heterogeneity in internet gaming disorder
Abstract Background Internet gaming disorder (IGD) is associated with abnormal functional connectivity (FC) in brain networks. However, findings from resting-state functional magnetic resonance imaging studies are highly inconsistent, likely due to individual heterogeneity in IGD-related neural…
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Artikel Jurnal
Pre-/pro and synbiotics on anxiety and depression symptoms: a GRADE assessed systematic review and meta-analysis of randomized controlled trials
Abstract Background The influence of pre-/pro-/synbiotics on depressive and anxiety symptoms remains ambiguous. This systematic review and meta-analysis aimed to clarify the impact of these interventions on mental health outcomes in adults. Methods A systematic search was conducted across PubMed…
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Artikel Jurnal
Efficacy and safety of repetitive transcranial magnetic stimulation in anorexia and bulimia nervosa: a systematic review and meta-analysis
Abstract Objective This systematic review and meta-analysis aimed to evaluate the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in patients with anorexia nervosa (AN) and bulimia nervosa (BN), focusing on its impact on psychological, psychopathological, neurocognitive…
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Artikel Jurnal
A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets
Abstract Background Trazodone, an antidepressant, has only been approved for use in major depressive disorder (MDD), but has demonstrated potent therapeutic potential in various conditions, such as insomnia and anxiety. It targets multiple serotonergic, adrenergic, and histaminergic receptors…
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Artikel Jurnal
Antidepressant prescribing patterns and patient-reported adverse effects: a cross-sectional study from Pakistan
Abstract Background Antidepressant prescribing practices and Adverse-effect profiles are poorly characterised in Pakistan, highlighting the need for systematic evaluation. This study aimed to assess prescribing patterns, validate the Urdu version of the Antidepressant Side-Effect Checklist…
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Artikel Jurnal
Patient perspectives on the challenges, obstacles, and opportunities in discussing and managing anhedonia in major depressive disorder (MDD): a focus group study
Abstract Background Major depressive disorder (MDD) is a common mental health disorder and a leading cause of disease burden. Anhedonia—defined for participants in this study as diminished interest, motivation, or ability to experience pleasure in daily activities—is a core symptom required for…
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Artikel Jurnal
Examining clinical relevance of interpretation inflexibility in social contexts
Abstract Growing research highlights interpretation inflexibility as a key transdiagnostic mechanism across psychopathologies. Yet, few studies have examined its role in everyday socio-emotional processing. This review bridges that gap by exploring how interpretation inflexibility contributes to…
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