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Biology Direct
Scopus
ISSN 1745-6150 · BMC · 1.072 artikel di indeks
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Artikel Jurnal
Microvesicles, exosomes and their combinations with cytoplasmic organelles: from their discovery to their innovative roles in clinical medicine
Abstract Extracellular Vesicles (EVs), two types of different size: microvesicles and exosomes, generated by all types of cells. EV interactions with lysosomes and/or autophagosomes, induce establishment of combined forms. EVs are composed by a surface membrane of lipid bilayer rich of specific…
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Artikel Jurnal
Resilient gut microbiome is linked to immune control in HIV-1 infection
Abstract Background HIV-1 affects millions of people globally, and in rare cases, individuals known as “elite controllers” (EC) maintain undetectable viral load without antiretroviral therapy (ART). Given the crucial role of the gut microbiota in maintaining immune system homeostasis, this study…
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Artikel Jurnal
A phospho-switch to trigger mitotic chromosome condensation
Abstract One of the most eye-catching events in cell biology is the condensation of chromosomes. During mitosis, the diffuse interphase chromatin rearranges into compact, rod-shaped chromosomes that can be precisely segregated between the daughter cells. This drastic reorganization of the DNA…
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Artikel Jurnal
Acrylamide disrupts meiotic G2/M transition and SAC activity during oocyte maturation
Abstract Acrylamide is a synthetic material which is widely used in water treatment and paper manufacturing, and it is also generated from food formation, which shows neurological effects, skin irritation, or reproductive toxicity. Several studies focused on the effects of acrylamide on…
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Artikel Jurnal
Radix Rehmanniae Preparata polysaccharide promoted zebrafish heart regeneration by activating the IFN-γ/NF-κB signaling axis
Abstract Radix Rehmanniae Praeparata polysaccharide (RRPP), a primary bioactive component of the traditional Chinese medicine Rehmannia, possesses diverse pharmacological activities including immunomodulatory effects. While its cardioprotective potential has been noted, the role of RRPP in…
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Artikel Jurnal
Revealing FPR1 as a potential pathogenic biomarker for aortic dissection based on Mendelian randomization, single-cell transcriptome and clinical data analysis
Abstract Background Aortic dissection is characterized by immune cell infiltration and vascular inflammation, yet its molecular mechanisms remain unclear. This study investigates the role of immune-related genes in AD pathogenesis. Methods We integrated Mendelian randomization and transcriptomic…
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Artikel Jurnal
Integrative multi-omics analysis widens annotation and functional insights into long non-coding RNAs of Arabidopsis thaliana
Abstract Background Long non-coding RNAs (lncRNAs) play key roles in regulating plant growth, development, and stress responses. Despite their increasing identification in plant transcriptomes, a systematic characterization of lncRNAs is still lacking, leaving a significant knowledge gap. To…
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Artikel Jurnal
GPR43 alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome activation via β-arrestin 2
Abstract Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe respiratory ailments globally, with the NLRP3 inflammasome playing a crucial role in the progression of ALI. G protein-coupled receptor 43 (GPR43) plays a role in regulating the immune system and…
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Artikel Jurnal
A novel synergistic action of phage vB_PaeP_GZMU_A1002 with allicin against carbapenem-resistant Pseudomonas aeruginosa
Abstract The increasing problem of bacterial resistance to antibiotics necessitates the exploration of innovative antimicrobial strategies. Phage therapy is a promising solution; however, naturally occurring phages targeting resistant pathogens remain limited. This study aimed to isolate and…
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Artikel Jurnal
Comprehensive pan-cancer analysis reveals SH3GLB1 is a novel prognostic biomarker with immunomodulatory potential
Abstract Background Cancer continues to represent a significant global health challenge, underscoring the urgent need for novel biomarkers to enhance early diagnosis and prognosis prediction. SH3 domain-containing GRB2-like B1 (SH3GLB1), also known as Bax interaction factor 1 (BIF-1), is a key…
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Artikel Jurnal
Solute carrier family (SLC) amino acid transporters are upregulated in cutaneous squamous cell carcinoma
Abstract Solute carrier family (SLC) amino acid transporters play key role in maintaining a continuous supply of nutrients to cancer cells. Non melanoma skin tumours, the most common cancer type worldwide, undergo extensive metabolic rewiring to survive under hostile conditions. To adapt to…
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Artikel Jurnal
S100A4 triggeres the pyroptosis of vsmcs: association with mitochondrial damage, impaired mitophagy, and Ca2+ dysregulation
Abstract Background Atherosclerotic occlusive disease of the lower extremities (ASO-LE) is associated with high rates of disability and mortality, and even after surgery, the rate of long-term lumen patency remains low. Vascular smooth muscle cells (VSMCs) are key players in atherosclerosis. The…
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Artikel Jurnal
Synergistic anticancer effects of cabozantinib and cuproptosis induction driven by DHRS2-KAT2A-H3K27ac axis in clear cell renal cell carcinoma
Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of kidney cancer, representing about 70–80% of all renal cell carcinomas. Cuproptosis, a recently identified mode of cell death, has increasingly been linked to tumor initiation, progression, and drug…
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Artikel Jurnal
Polarity protein Par3 deficiency promotes metastasis of bladder cancer via interaction of Ppp1r12c
Abstract Background Bladder cancer (BC) remains the leading global mortality and poor prognosis in genitourinary malignancies, especially in patients with metastasis. Results In this study, we demonstrate that loss of polarity protein partitioning defective 3 (Par3, encoded by PARD3) is correlated…
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Artikel Jurnal
Catalase inhibits tumor growth by alleviating oxidative stress and promoting the polarization of tumor-associated macrophage from M2 to M1 phenotype in non-small cell lung cancer
Abstract Background Catalase (CAT) plays a crucial role in converting hydrogen peroxide (H₂O₂) into water and oxygen, which can help alleviate oxidative stress in body. However, whether CAT is associated with the prognosis and immunotherapy response in patients with non-small cell lung cancer…
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Artikel Jurnal
Robust SH2 binding affinity indicates minimal SH3-to-SH2 communication in Grb2
Abstract Growth factor receptor–bound protein 2 (Grb2) is a modular adaptor that links activated receptor tyrosine kinases to downstream signaling pathways through its SH3–SH2–SH3 architecture. Previous studies showed that perturbations in the SH2 domain can influence ligand binding at the…
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Artikel Jurnal
Running exercise alleviates chronic heart failure by promoting cardiomyocyte autophagic flux through the NEAT1–QKI affecting Beclin1/LC3B mRNA stability
Abstract As the end-stage manifestation of cardiovascular diseases (CVDs), chronic heart failure (CHF) is associated with high morbidity and mortality. Our previous study showed that Running exercise could improve CHF by inducing autophagy, but the underlying mechanisms and applicability remain…
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Artikel Jurnal
The PTHR1/PKA/CREB1 axis promotes osteosarcoma progression by activating the PVT1/miR-590-3p/AXIN2 ceRNA network to induce epithelial-mesenchymal transition
Abstract Background Osteosarcoma (OS) remains a clinically challenging primary bone tumor because of its strong metastatic potential and unsatisfactory outcomes in advanced cases. Parathyroid hormone receptor 1 (PTHR1), a receptor closely associated with bone-related signaling, has not been fully…
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Artikel Jurnal
Identification and prognostic analysis of genes related to CTNNB1 mutations in hepatocellular carcinoma
Abstract Background Mutations in CTNNB1 are recognized oncogenic drivers of hepatocellular carcinoma (HCC); however, the downstream effector molecules and their prognostic significance remain incompletely defined. In this study, we developed a mutant CTNNB1 gene signature (MCGS) to predict CTNNB1…
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