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Cell Division
Scopus
ISSN 1747-1028 · BMC · 330 articles in the index
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Journal Article
Research progress on vasculogenic mimicry in colorectal cancer: mechanisms and therapeutic
Abstract Colorectal cancer (CRC) is the third most common malignant tumor worldwide and is characterized by high incidence and mortality rates. In the chemotherapeutic treatment of CRC, antiangiogenic therapy is utilized throughout the entire disease course, particularly for highly metastatic…
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Journal Article
The TMPO-AS1/hsa-let-7b-5p regulatory axis shapes transcriptional heterogeneity and immune landscape in lung adenocarcinoma
Abstract Background Lung adenocarcinoma (LUAD) is a highly heterogeneous malignancy with poor clinical outcomes, underscoring the urgent need for robust prognostic biomarkers and therapeutically tractable regulatory molecules. Long non-coding RNAs (lncRNAs) have emerged as key modulators of tumor…
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Journal Article
PTTG1-mediated the transcription of c-myc promotes retinoblastoma progression
Abstract Purpose The oncogenic potential of pituitary tumor-transforming gene-1 (PTTG1) has been well-documented in multiple cancer types. This study explored the biological role and molecular mechanism of PTTG1 in retinoblastoma. Methods PTTG1 and c-myc expression levels were assessed through…
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Journal Article
Role of cadherin gene dysregulation in WNT signaling and nasopharyngeal carcinoma
Abstract Background Nasopharyngeal carcinoma (NPC) is a malignancy associated with genetic alterations and tumor progression. Cadherin genes (CDH1, CDH2, and CDH3) play key roles in cell adhesion, migration, and tissue integrity, and their role in NPC remains underexplored. This study investigates…
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Journal Article
p53 overexpression counteracts the pro-survival effect of Bcl-2 by restoring MAMs function in cutaneous squamous cell carcinoma
Abstract Background Cutaneous squamous cell carcinoma (cSCC) is a prevalent type of skin cancer, and its development is strongly associated with impaired regulation of apoptosis. The anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) and the tumor suppressor p53 play pivotal roles in controlling…
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Journal Article
Esculentoside A suppresses the malignant progression of hepatocellular carcinoma by promoting RORB
Abstract Hepatocellular carcinoma (HCC) is a highly aggressive disease associated with a poor prognosis. The present study attempts to discover the potential of esculentoside A (EsA) in inhibiting HCC progression. Cell viability was assessed using the Cell Counting Kit-8 assays. At the same time…
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Journal Article
Overexpression of ENDOD1 inhibits proliferation, migration, and invasion of colorectal cancer
Abstract Objective This study aimed to investigate the biological function and the molecular mechanism of ENDOD1 in colorectal cancer (CRC) progression. Methods CRC-related differentially expressed genes (DEGs) were screened by analyzing GEO datasets (GSE41657, GSE8671, GSE41328, and GSE75548). The…
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Journal Article
The adipogenesis-related gene CEBPD as a prognostic biomarker and functional tumor suppressor in breast cancer
Abstract This study explores the role of adipogenesis-related genes (ARGs) in breast cancer, focusing on CEBPD, a key gene linked to adipogenesis. Using the TCGA-BRCA dataset, differentially expressed ARGs (DARGs) were identified, revealing 26 upregulated and 57 downregulated genes. CEBPD emerged…
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Journal Article
Linalool targets NR3C2 to inhibit NF-κB-mediated gastric cancer progression
Abstract Gastric cancer (GC) is a major global health challenge. This study explores the efficacy of linalool in GC and further elucidates its underlying mechanisms. Linalool inhibited the proliferation, migration, and invasion of GC cells and prevented transplanted tumor growth in nude mice…
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Journal Article
IL-8 drives EMT and malignant progression in chronic obstructive pulmonary disease-associated lung cancer via STAT3 signaling
Abstract Background Chronic obstructive pulmonary disease (COPD) increases the risk of lung cancer (LC), but the underlying mechanisms remain unclear. Interleukin-8 (IL-8), a proinflammatory cytokine, has been implicated in tumor progression and epithelial–mesenchymal transition (EMT). This study…
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Journal Article
PRRX2-CNTN3 axis promotes epithelial-to-mesenchymal transition and metastasis in colorectal cancer
Abstract Objective The study investigates the role of CNTN3 in colorectal cancer (CRC) progression and its transcriptional regulation by PRRX2, exploring their potential contributions to epithelial-to-mesenchymal transition (EMT) and metastasis. Methods Bioinformatics analysis of CRC datasets…
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Journal Article
SOCS3 suppresses glioblastoma growth via JAK-STAT inhibition and mitochondrial unfolded protein response activation
Abstract Introduction Glioblastoma (GBM) represents one of the most aggressive brain malignancies, characterized by rapid proliferation and pronounced resistance to apoptosis, resulting in poor therapeutic outcomes. Suppressor of cytokine signaling 3 (SOCS3), a crucial negative regulator of the…
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Journal Article
The roles and pathways of Hsa_circ_0000285 in cancer: a potential target for cancer therapy
Abstract Circular RNA (circRNA) is a unique type of non-coding RNA molecule characterized by a closed circular structure, exceptional stability, and the ability to act as miRNA sponges, thereby relieving their inhibitory effects on downstream target genes, thus regulating cancer cell growth and…
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Journal Article
hsa-let-7b-5p-associated BUB1/TMPO-AS1 ceRNA axis identified as a potential biomarker in lung adenocarcinoma
Abstract Objective BUB1, a key mitotic checkpoint kinase, is often dysregulated in cancer, yet its regulatory mechanism remains unclear. This study investigates the BUB1-centered miRNA–lncRNA–mRNA (ceRNA) network, its role in cell cycle regulation and immune modulation. Methods Prognostic…
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Journal Article
FOXP3-activated KCNMB2-AS1 promotes clear cell renal cell carcinoma through the miR-744-3p/CD1D axis
Abstract Background Long noncoding RNAs (lncRNAs) are key regulators in cancer progression. Among them, KCNMB2 antisense RNA 1 (KCNMB2-AS1) has been identified as an oncogenic lncRNA in several tumor types; however, its role in clear-cell renal cell carcinoma (ccRCC) remains largely unexplored…
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Journal Article
Role of LINC00332 in colorectal cancer progression and paclitaxel resistance
Abstract Background Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer deaths. Standard therapeutic management is faced with challenges like treatment resistance and late-stage diagnosis, highlighting a need for better diagnosis. LncRNAs are crucial in CRC…
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Journal Article
METTL3-mediated m6A methylation of LncRNA DUXAP8 promoted esophageal squamous cell carcinoma progression by activating the PI3K/AKT signaling pathway
Abstract Background To uncover the mechanism of METTL3 and LncRNA DUXAP8 in esophageal squamous cell carcinoma (ESCC) progression. Methods LncRNA DUXAP8 expression was assessed by qRT-PCR. Its overexpression and knockdown in ESCC cells were evaluated for effects on viability and metastasis. WB…
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Journal Article
HOXD13 knockdown attenuates apoptosis in prostate cancer via the upregulation of MDM2/p53 signaling
Abstract Background Prostate cancer (PCa) is a common leading cause of death worldwide and is recognized as the second most frequently diagnosed cancer in the male population, making it a significant focus of long-term oncological research. The HOXD13 gene, belonging to the HOX gene family, has…
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Journal Article
LncPRESS1 promotes the progression and cisplatin resistance of breast cancer through upregulation of ENO1 and activation of glycolysis
Abstract Background Overexpression or downregulation of long noncoding RNA (lncRNA) plays an essential role in the progression and chemotherapy-resistant of breast cancer (BRCA). LncPRESS1 is a lncRNA regulated by p53, suggesting its potential in participating in carcinogenesis. However, few…
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Journal Article
FGF4 drives tumor progression in triple-negative breast cancer via IL6/STAT3-mediated macrophage M2 polarization and immune suppression
Abstract Objective This study investigates how Fibroblast Growth Factor 4 (FGF4) drives triple-negative breast cancer (TNBC) progression by modulating macrophage polarization through the IL6/STAT3 signaling axis, with a focus on immune suppression and tumor microenvironment remodeling. Methods TNBC…