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Infectious Agents and Cancer
Scopus
ISSN 1750-9378 · BMC · 990 artikel di indeks
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Artikel Jurnal
Role of gut microbiota in cancer modulation: molecular mechanisms and emerging therapeutic strategies
Abstract The gut microbiota exerts profound effects on host physiology, immunity, and disease susceptibility, with growing evidence implicating its role in cancer initiation, progression, and therapy response. Dysbiosis and microbial-derived metabolites contribute to oncogenesis by modulating…
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Artikel Jurnal
Investigation of the presence of cervical human papillomavirus and the distribution of preinvasive lesions in patients using immunomodulators-Inosine Pranobex
Abstract Background Human papillomavirus treatment is known to benefit from humoral and cellular immunity. It has been demonstrated that the immunomodulatory drug Inosine Pranobex (IP) increases T-cell proliferation, the number and function of natural killer cells, and the levels of T helper 1-type…
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Artikel Jurnal
Illuminating the pathological, immunohistochemical, and molecular investigations of myelocytomatosis in chicken embryos
Abstract Avian leukosis virus Subgroup-J (ALV-J) is an avian retrovirus affecting a wide range of avian species, and has posed a great threat to the local poultry with significant losses. In Egypt, ALV-J has been actively monitored in various breeder flocks. This study investigated 200 eggs from…
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Artikel Jurnal
Viral zoonosis and human cancer: further perspectives and considerations
Abstract A recent review by Aguayo appearing in Infectious Agents and Cancer gave a timely overview of viruses that have been associated with human breast cancer. In this Matters Arising article, we discuss some critical additional points and concerns that are pertinent for this important and…
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Artikel Jurnal
Prevalence of Gardnerella vaginalis in HR HPV-positive women and its association with squamous intraepithelial lesions
Abstract Background The human papillomavirus (HPV) is the most common sexually transmitted infection (STI) worldwide. Only a small percentage of high-risk (HR) HPV infections progress to cervical precancer and cancer. Recent research indicates the potential association between the variation of…
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Artikel Jurnal
The prognosis characteristics of HIV/HBV co-infection after antiviral therapy: a comprehensive review
Abstract Co-infection of HIV and HBV is still a major global public health concern. Co-infected people have a nearly threefold increased risk of end-stage liver disease, with a noticeably faster development to cirrhosis and hepatocellular carcinoma than those with HIV mono-infection. Based on the…
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Artikel Jurnal
Prevalence of high-risk human papillomavirus types among women aged 30–49 years in the Chuy region, Kyrgyzstan
Abstract Introduction Human papillomavirus (HPV) is a leading cause of cervical cancer globally. High-risk (HR) HPV types HPV16 and 18 are responsible for 70% of cases. However, limited data exist for Kyrgyzstan, where cervical cancer is the second most common cancer in women. This study aimed to…
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Artikel Jurnal
Differential expression and prognostic role of ACACA, ACLY, and FASN in schistosomiasis-associated versus hepatitis B virus-related liver cancer
Abstract Objective To investigate the clinicopathological differences between schistosomiasis-related liver cancer (Sj-LC) and hepatitis B virus-related liver cancer (HBV-LC), as well as the expression and prognostic significance of key lipid metabolism enzymes (ACACA, ACLY, FASN). Methods A…
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Artikel Jurnal
Silencing HPV: the rise of RNA therapeutics in cervical cancer
Abstract Despite the availability of preventative HPV vaccinations, cervical cancer remains a worldwide health concern. It is mostly caused by persistent infection with high-risk human papillomaviruses. Therapeutic techniques targeting the viral oncogenes E6 and E7, which are constitutively…
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Artikel Jurnal
Bacterial vaginosis in microscopic examination of Pap smears in patients with high-risk HPV is associated with viral persistence and cytological progression in a longitudinal study
Abstract Background The vaginal microbiome is increasingly studied using sequencing approaches; however, the exact bacterial community structure in vaginal diseases, e.g. bacterial vaginosis (BV), remains unclear. Vaginal Pap smears routinely obtained in preventive screening programs can also be…
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Artikel Jurnal
Novel C-terminal HBx truncation (G135) in genotype D1 HBV: predicted effects on oncogenic signaling
Abstract Background & aims Hepatitis B virus X protein (HBx) is a multifunctional viral regulator implicated in hepatocellular carcinoma (HCC). We aimed to characterize HBx mutations in liver tissue samples from Iranian patients with HCC and explore their potential structural and functional…
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Artikel Jurnal
Hepatitis B virus pregenomic RNA is associated with malignant phenotypes and postoperative survival in HBV-related intrahepatic cholangiocarcinoma
Abstract Background Chronic hepatitis B virus (HBV) infection contributes to infection-associated liver carcinogenesis. However, the biological and clinical relevance of HBV pregenomic RNA (pgRNA), a marker of residual viral transcriptional activity, in HBV-related intrahepatic cholangiocarcinoma…
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Artikel Jurnal
CD44 expression associates with EBV LMP1, reduced CD8⁺ T cell infiltration, and lower PD-L1 combined positive score in nasopharyngeal carcinoma
Abstract Background Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated malignancy characterized by a highly immune-infiltrated yet clinically heterogeneous tumor microenvironment. Iron metabolism has been proposed as a potential determinant of tumor progression and immune…
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Artikel Jurnal
Paired box 1 gene methylation as a promising triage strategy for atypical squamous cells: a retrospective comparison with high-risk HPV testing in cervical cancer screening
Abstract Background The triage of Atypical Squamous Cells (ASC) is pivotal in cervical cancer (CC) screening. This study aimed to evaluate the performance of paired box 1 gene methylation (PAX1 m ) testing for triaging cervical intraepithelial neoplasia (CIN) grade 3 or worse (CIN3+) in an ASC…
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Artikel Jurnal
Molecular characterization of HPV integrations in high-risk HPV-positive women and development of a prognostic signature based on integration-associated genes for cervical cancer
Abstract Background HPV integration into the human genome is a key molecular event in the progression of cervical cancer carcinogenesis. Methods This study utilized samples from high-risk HPV-positive women to investigate HPV integration. Integration-associated genes were screened based on HPV-DNA…
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Artikel Jurnal
Penile HPV prevalence among high-risk men in Sri Lanka: baseline insight for HPV prevention strategies in a lower-middle-income country
Abstract Background Human Papillomavirus (HPV) infection is the most common sexually transmitted viral infection in the world. Persistent infection lasting more than two years, particularly with High-Risk (HR) HPV genotypes, can lead to malignant transformation. Estimating HPV prevalence among…
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Artikel Jurnal
High-risk human papillomavirus genotypes in cervical squamous cell carcinomas diagnosed in Rwanda
Abstract Background Cervical cancer is driven by long persisting high-risk HPV infections(hrHPV). HIV+ women with hrHPV co-infections are sixfold more likely to develop cervical cancer compared with HIV- women. To inform Rwandan policy on HPV vaccines and screening strategies, we assessed the…
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Artikel Jurnal
Combined C-terminal truncation and point mutations in HBx in genotype D1 HBV-associated hepatocellular carcinoma
Abstract Background Hepatitis B virus (HBV) infection remains a major global cause of hepatocellular carcinoma (HCC), with the X protein (HBx) playing a central role in viral replication and host-virus interactions. Genetic variability within HBx, particularly in genotype D1, may influence disease…
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Artikel Jurnal
Acquired epidermodysplasia verruciformis presenting as isolated genital hypopigmentation in a renal transplant recipient: a rare case report
Abstract Epidermodysplasia verruciformis (EV) is a rare genodermatosis resulting from mutations in the EVER1/EVER2 genes, that increase vulnerability to beta-human papillomavirus (β-HPV) infection. The acquired form (AEV) develops in immunocompromised individuals, particularly organ transplant…
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Artikel Jurnal
High-risk human papillomavirus positivity and associated factors among women living with HIV in public health facilities of Mekelle, Northern Ethiopia
Abstract Background Worldwide, it is believed that high-risk human papillomavirus (hr-HPV) strains are the root cause of many types of cancers, including cervical cancer, anorectal cancers, vaginal cancers, and penile cancers, with an estimated 922, 728 females diagnosed with HPV-related cancer in…