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Therapeutic Advances in Respiratory Disease
Scopus
ISSN 1753-4666 · SAGE Publishing · 1.040 artikel di indeks
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Artikel Jurnal
Prognostic nutritional index predicts nintedanib outcomes in idiopathic pulmonary fibrosis
Background Malnutrition is common in patients with idiopathic pulmonary fibrosis (IPF), and potentially affects the tolerability of antifibrotic therapy and survival. The prognostic nutritional index (PNI) is a validated prognostic marker in various diseases; however, its role in antifibrotic…
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Artikel Jurnal
Lung organoids as emerging models in idiopathic pulmonary fibrosis research: Current applications, challenges, and future directions
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with progressive, irreversible scarring and a median survival of approximately 3–5 years after diagnosis. Current therapies (nintedanib, pirfenidone) modestly slow progression but do not halt or reverse fibrosis, creating a critical…
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Artikel Jurnal
Patient-reported experiences of pulmonary fibrosis in the UK: The role of sex and disease subtypes in symptomology, diagnosis and care
Background Pulmonary fibrosis (PF) is associated with substantial symptom burden, complex diagnostic pathways and varied access to specialist services. It is important to understand patient and carer experiences to highlight disparities and inform improvements in care. Objectives To explore…
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Artikel Jurnal
Novel hepatic function-based prognostic prediction model for pulmonary arterial hypertension
Background Hepatic dysfunction is increasingly recognized as a contributor to adverse outcomes in patients with pulmonary arterial hypertension (PAH). However, current prognostic models for PAH do not incorporate hepatic function parameters. Objectives To develop and validate a novel risk…
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Artikel Jurnal
The diagnostic and prognostic role of MMP-1 and MMP-9 plasma concentrations in idiopathic pulmonary fibrosis
Background Idiopathic pulmonary fibrosis (IPF) represents a chronic and irreversible progressive disease, while acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) represents a catastrophic event in the course of the disease with high mortality. So far, there is no known accurate biomarker…
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Artikel Jurnal
Real-world analysis on hemodynamic effectiveness and adverse events of selexipag in pulmonary arterial hypertension
Background Selexipag, an oral IP prostacyclin receptor agonist, improves outcomes in pulmonary arterial hypertension (PAH); however, real-world hemodynamic data and the relationship between adverse events (AEs) and treatment response are limited. Objectives The aims of this study were to evaluate…
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Artikel Jurnal
Silent threat: A case report of acute fulminant exogenous lipoid pneumonia leading to severe ARDS
Exogenous lipoid pneumonia (ELP) is a rare pulmonary disorder resulting from the aspiration or inhalation of exogenous lipid substances. While most documented cases follow an indolent, chronic course and are associated with favorable outcomes, fulminant postoperative ELP remains exceedingly…
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Artikel Jurnal
Endoplasmic reticulum stress and maladaptive repair in fibrotic interstitial lung diseases: A human-evidence-based narrative review
Fibrotic interstitial lung diseases (ILDs) are characterized by progressive extracellular-matrix accumulation but arise from biologically diverse injuries. This narrative review examines endoplasmic reticulum (ER) stress as a context-dependent regulator of maladaptive repair, prioritizing evidence…
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Artikel Jurnal
Balloon pulmonary angioplasty for occlusive lesions of pulmonary artery in Takayasu arteritis: A cohort study
Background Occlusive pulmonary arterial lesions represent a major technical challenge for balloon pulmonary angioplasty (BPA) in patients with Takayasu arteritis–associated pulmonary artery involvement. However, evidence and procedural guidance regarding BPA for occlusive lesions in this population…
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Artikel Jurnal
Artificial intelligence responses to bronchiectasis patients’ questions: the AIR-BE study
Background: The popularity of Generative Artificial Intelligence (AI)-powered chatbots is growing, with more patients using AI to understand respiratory conditions, including bronchiectasis. The quality of AI’s responses to bronchiectasis-related questions has not previously been evaluated…
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Artikel Jurnal
Blood eosinophils in COPD: are biologics for everyone?
Background: Type 2 (T2) biologics represent a promising treatment option for chronic obstructive pulmonary disease (COPD) patients with eosinophilic inflammation. Objectives: To evaluate the prevalence of stable COPD patients who may be eligible for T2 biologics. Design: Real-world, retrospective…
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Artikel Jurnal
Impact of early therapeutic modality on 28-day mortality in immunocompromised patients with opportunistic pulmonary infections: a multicenter retrospective study
Background: Opportunistic pulmonary infections remain a significant threat in immunocompromised cases. Objectives: This study aims to evaluate the impact of early therapeutic modalities on 28-day mortality in non-AIDS and non-solid tumor immunocompromised patients hospitalized with opportunistic…
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Artikel Jurnal
Effects of dual bronchodilation on right ventricular function and troponin-I in newly diagnosed, moderate-to-severe chronic obstructive pulmonary disease: a prospective real-world observational study
Background: Chronic obstructive pulmonary disease (COPD) is associated with right ventricular (RV) dysfunction and subclinical myocardial injury. The effects of dual bronchodilation on RV function and cardiac injury biomarkers remain limited. Objectives: To evaluate 12-week changes in pulmonary…
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Artikel Jurnal
Social determinants of health, cystic fibrosis-related diabetes, and mental health in adult patients with cystic fibrosis: a critical synthesis of narrative review
The population of adults with cystic fibrosis (CF) exceeds that of the pediatric CF population, and life expectancy for people with CF (PwCF) continues to improve, resulting in an adult CF population with chronic extrapulmonary comorbid conditions, including CF-related diabetes (CFRD), a common…
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Artikel Jurnal
Diagnostic sensitivity and safety of visceral pleural biopsy under semi-rigid medical thoracoscopy in patients with undiagnosed exudative pleural effusions: a retrospective study
Background: Medical thoracoscopy (MT) is primarily employed to obtain histopathological evidence via parietal pleural biopsy. However, parietal pleural lesions are not uniformly accessible, and evidence on visceral pleural biopsy remains limited. Objectives: This study aimed to investigate the…
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Artikel Jurnal
Clinical, hemodynamic, and safety outcomes of sotatercept in pulmonary arterial hypertension: a meta-analysis of randomized trials with time-to-event data
Background: Pulmonary arterial hypertension (PAH) remains progressive despite contemporary background therapy. Sotatercept is a novel activin signaling inhibitor that targets pulmonary vascular remodeling and may improve clinical and hemodynamic outcomes. Objectives: To evaluate the efficacy…
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Artikel Jurnal
Novel mutations in Birt-Hogg-Dubé patients and potential intervention of mRNA
Background: Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder caused by folliculin ( FLCN ) gene mutations, with ethnically heterogeneous mutational spectra. Current management is primarily supportive and lacks curative therapies. Objectives: This study aimed to characterize the…
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Artikel Jurnal
Arterial stiffness and wave reflection profiles in patients with asthma: the role of hemodynamic determinants
Background: Asthma is a heterogeneous inflammatory airway disease increasingly recognised to be associated with elevated cardiovascular risk. Arterial stiffness, commonly assessed by pulse wave velocity (PWV), is a well-established predictor of cardiovascular events. However, it remains unclear…
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Artikel Jurnal
Cerebral hypoperfusion in pulmonary arterial hypertension: Association with right ventricular dysfunction and risk stratification
Background Pulmonary arterial hypertension (PAH) is a progressive disease that affects the central nervous system. The cardiopulmonary-brain axis hypothesis links right ventricular dysfunction to cerebral hypoperfusion, yet the association between regional cerebral blood flow (CBF) alterations…
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