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Therapeutic Advances in Neurological Disorders
Scopus
ISSN 1756-2864 · SAGE Publishing · 1,162 articles in the index
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Journal Article
Brain volume and network changes in pediatric MOGAD: A retrospective cohort study based on non-acute brain MRI
Background Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), as the most common type of pediatric central nervous system idiopathic inflammatory demyelinating diseases, has an unclear impact on brain volume and brain networks in children. Objective To investigate differences…
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Journal Article
Telitacicept as add-on therapy for myasthenic crisis: A retrospective cohort study
Background Myasthenic crisis (MC) is a life-threatening exacerbation of myasthenia gravis (MG) that often requires mechanical ventilation (MV) and intensive care. Following acute stabilization, optimal maintenance immunotherapy remains uncertain in some patients. Objectives To evaluate the efficacy…
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Journal Article
Bridging the autonomic divide: Closed-loop spinal cord stimulation as a dynamic therapy for parkinsonian orthostatic hypotension
Neurogenic orthostatic hypotension (nOH) in Parkinson’s disease (PD) represents a potential “central-peripheral disconnection” rather than an isolated peripheral deficit. Driven by progressive sympathetic denervation, this uncoupling leaves the peripheral effectors in a fragile, “sick-but-not-dead”…
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Journal Article
Cladribine use for multiple sclerosis with autoimmune comorbidities: retrospective analysis of the French MS registry, case series, and therapeutic considerations
Background: Autoimmune (AI) comorbidities are common in people with multiple sclerosis (MS) and may complicate therapeutic management, particularly when dual immunosuppression is required. Cladribine, an immune reconstitution therapy approved for relapsing MS, has shown potential benefit in…
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Journal Article
Remote brainstem lesion associated with lower cervical spinal dural arteriovenous fistula—venous outflow bottleneck: a case report and literature review
Spinal dural arteriovenous fistula (SDAVF) is an important cause of venous congestive myelopathy, as timely treatment offers the potential for neurological recovery. However, it is sometimes misdiagnosed when presenting with atypical intracranial or brainstem lesions. Although venous congestion in…
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Journal Article
Residual early neurological deterioration following dual antiplatelet in stroke: post hoc analysis of the ATAMIS trial
Background: A clinically significant proportion of patients experience early neurological deterioration (END) despite receiving dual antiplatelet therapy (DAPT) for acute ischemic stroke. It is crucial to identify this specific population for risk stratification and targeted intervention…
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Journal Article
Clinical, imaging, and immunotherapeutic features in MOGAD: a retrospective real-world cohort in Northern China
Background: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a clinically heterogeneous demyelinating disorder. Current knowledge of its phenotypic spectrum and optimal treatment strategies, especially in Asian populations, remains limited. Objectives: This study aimed to…
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Journal Article
Narcolepsy with co-occurring epilepsy: diagnostic pitfalls and management strategy
Narcolepsy and epilepsy are chronic neurological disorders that occasionally coexist. Overlapping symptoms, such as sudden loss of muscle tone and uncertainty regarding preservation of awareness, frequently complicate accurate diagnosis and ambiguity remains regarding optimal therapeutic…
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Journal Article
Single-channel EEG captures tDCS-induced changes in neural reactivity: a pilot study in disorders of consciousness patients and healthy controls
Background: Understanding and enhancing neural recovery in disorders of consciousness (DoC) remains a critical challenge in clinical care. Clinical scales such as the Coma Recovery Scale–Revised (CRS-R) are essential, but reflect behavioral responsiveness and may not fully capture subtle…
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Journal Article
Clinical heterogeneity and immunotherapy outcomes in anti-GAD65 antibody-associated autoimmune encephalitis: a retrospective study
Anti-glutamic acid decarboxylase 65 (GAD65) antibody-associated autoimmune encephalitis (AE) is characterized by diverse neurological manifestations and systemic autoimmune comorbidities, posing diagnostic and therapeutic challenges. This study aimed to investigate the clinical heterogeneity…
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Journal Article
Complement C5 inhibitors as add-on rescue treatment in severe AQP4-antibody neuromyelitis optica spectrum disorder attacks: a case series and literature review
Acute attacks of aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-Ab NMOSD) are typically managed with intravenous methylprednisolone, with therapeutic plasma exchange (PLEX) reserved for severe episodes. Despite these interventions, a subset of patients fails to respond and may…
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Journal Article
Changes in vaccination status, willingness and knowledge in patients with multiple sclerosis: Results from a five-year longitudinal study
Background Multiple sclerosis (MS) is a chronic immune-mediated disease requiring long-term management. Both the disease itself and disease-modifying therapies increase susceptibility to severe infections. Ensuring adequate vaccination in patients with MS is therefore essential. However, vaccine…
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Journal Article
Telitacicept for primary angiitis of the central nervous system: A real-world retrospective study
Background Primary central nervous system vasculitis (PACNS) is a rare inflammatory disease with limited treatment options. Telitacicept and high-resolution vessel wall imaging (HR-VWI) may offer new strategies for therapy and disease monitoring. Objective To evaluate the clinical efficacy and…
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Journal Article
Efficacy and safety of interleukin-6 receptor inhibitors in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD): A systematic review and meta-analysis
Background Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) can follow a relapsing course, yet evidence for effective maintenance therapy remains limited. Interleukin-6 receptor (IL-6R) inhibition has emerged as a potential relapse-prevention strategy. Objectives To evaluate…
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Journal Article
Spinal muscular atrophy: Biology, pathogenesis, and therapeutic advances
Recently instituted world-wide newborn screening programs for spinal muscular atrophy (SMA) permit identification of at-risk individuals prior to clinical presentation of the disease. Early intervention with one or more of the available disease-modifying therapies has dramatically changed the…
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Journal Article
Treatment patterns, access, and multidimensional burden of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in China: A nationwide cross-sectional study
Background Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare demyelinating disorder with evolving diagnostic and treatment landscape. Real-world evidence on treatment patterns, access, and disease burden remains limited, particularly in China. Objectives To…
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Journal Article
Evaluating the cognitive efficacy of marine-derived drugs in Alzheimer’s disease: A systematic review and Bayesian network meta-analysis
Background In recent years, marine-derived drugs for Alzheimer’s disease (AD) have attracted growing attention, but their comparative cognitive efficacy and safety remain uncertain because of inconsistent findings across studies. Objectives To compare the efficacy and safety of marine-derived…
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Journal Article
Relapse risk and functional outcomes in anti-LGI1 encephalitis: A multicenter retrospective analysis
Background Anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis presents relapse risk and potential functional impairment, with no established maintenance treatment guidelines. Objectives The study aimed to uncover prognostic signatures, and identify predictors of relapse and poor…
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Journal Article
Current practices in delirium prevention and treatment after acute stroke: results of a multicentre survey
Background: Delirium affects 10–30% of acute stroke patients, is associated with poor outcomes and places a substantial burden on healthcare staff. Evidence-based prevention and treatment strategies are limited, resulting in heterogeneous and poorly standardised delirium management in acute stroke…
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