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Journal of Functional Foods
Scopus
ISSN 1756-4646 · Elsevier · 504 articles in the index
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Journal Article
Unveiling the anticancer potential of isoorientin in digestive system cancers: mechanistic insights and nanoformulation strategies
Isoorientin, a C-glycosyl flavonoid belonging to the class of polyphenolic compounds, has recently gained attention for its superior pharmacological profile compared to other polyphenols in anticancer research. Unlike many flavonoids, such as quercetin or luteolin, isoorientin exhibits higher…
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Journal Article
Beta vulgaris L. extract and betanin alleviate dextran sulfate sodium (DSS)-induced colitis in mice by enhancing the intestinal barrier and regulating the gut microbiota to suppress inflammation
The gut microbiota and intestinal barrier are essential for intestinal homeostasis, and their disruption contributes to ulcerative colitis (UC). This study evaluated the protective effects of red beetroot extract (RE) and its major pigment, betanin (BN), against dextran sulfate sodium (DSS)-induced…
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Journal Article
Fucoxanthin mitigates lipopolysaccharide-induced acute liver injury by inhibiting hepatocyte apoptosis and pyroptosis
Acute liver injury (ALI) induced by lipopolysaccharide (LPS) represents a critical clinical challenge due to its high mortality and limited therapeutic options. Fucoxanthin (Fx), a marine-derived xanthophyll carotenoid, exerts hepatoprotective potential owing to its strong anti-inflammatory and…
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Journal Article
Fractionation, characterization, and gastrointestinal stability of anticancer and antioxidant peptides from sea cucumber (Holothuria scabra) hydrolysates
Sea cucumber hydrolysates with antioxidant and anticancer properties were prepared using papain hydrolysis. The protein hydrolysates were fractionated into peptide groups of >10 kDa (SCPH-I), 3–10 kDa (SCPH-II), 1–3 kDa (SCPH-III), and 0.05). The SCPH-III fraction was selected for peptide…
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Journal Article
Digestates of pea and fava bean proteins induce FGF19 in human intestinal HT29 cells: Evidence for a potential role of PPARγ
Plant-based proteins are promising alternatives to animal proteins for supporting muscle synthesis and preventing sarcopenia. This study examined whether protein digestates (PDs) from pea and fava bean isolates modulate intestinal Fibroblast Growth Factor 19 (FGF19), a hormone central to energy and…
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Journal Article
Rice bran fermented by Lactococcus lactis subsp. lactis MJM60392 reduces fat accumulation and adipose tissue on high-fat diet induced obese mice
Obesity, which can develop owing to a high-calorie diet and a sedentary lifestyle, may increase the risk of developing diabetes, hyperlipidemia, and cardiovascular diseases. Therefore, management through exercise and dietary control is essential. However, supplementation may be necessary if…
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Journal Article
Anticancer effects of Chlorella sorokiniana Shihira and R. W. Krauss extract via Bcl-2/Bax modulation and AMPK-α activation in hepatoma cells
Research on selectively inducing apoptosis in cancer cells is ongoing, yet effective natural compounds with fewer side effects are still needed. This study investigated the anticancer potential of Chlorella sorokiniana extract (CSE) in hepatoma cells. CSE showed high TPC (4.49 mg GAE/g DM) and TFC…
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Journal Article
Anti-inflammatory effect of Cyanidin-3-O-lathyroside from Eleutherococcus sessiliflorus in LPS-induced RAW 264.7 cells
The anti-inflammatory effect of cyanidin-3-O-lathyroside was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages by examining cell morphology and quantifying pro-inflammatory cytokine expression by qPCR. Extracellular cytokine levels and the activity of inflammatory mediators…
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Journal Article
A synbiotic supplement reduces body fat and increases GLP-1 secretion in a pilot clinical study
Obesity is closely associated with gut microbiota and their metabolites. We developed a multi-component synbiotic supplement that includes lychee polyphenols, Bifidobacterium longum, Bifidobacterium animalis, methionine, and other supportive ingredients such as prebiotics and postbiotics. A 5-week…
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Journal Article
Sparalide B from Sparassis latifolia inhibits early adipogenesis in 3T3-L1 adipocytes via β-catenin-dependent downregulation of PPARγ and C/EBPα
Sparalide B, a phthalide isolated from Sparassis latifolia (S. latifolia), was structurally assigned as 4,5,7-trihydroxy-6-ethoxyphthalide by high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR) (1H, 13C, heteronuclear multiple bond correlation…
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Journal Article
Dietary polyphenols as functional food bioactives: Nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant and immunomodulatory mechanisms in combating bacterial infections
The rising threat of antimicrobial resistance (AMR) highlights the need for novel strategies to fight against microbial pathogens while strengthening host defenses. Dietary polyphenols abundant in fruits, vegetables, and food byproducts, could offer dual antimicrobial and host-protective effects…
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Journal Article
Curcumin as a multi-target nutritional intervention alleviates exercise-induced injuries from overtraining: intervention efficacy and mechanism of action
Curcumin (CUR), a natural polyphenol, exerts antioxidant, anti-inflammatory, and metabolic regulatory actions in exercise physiology and may help ameliorate overtraining-induced multi-organ dysfunction and delayed recovery states associated with overtraining syndrome (OTS). This review…
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Journal Article
Gut microbiota and serum metabolites reveal the effects of chongqing tuo tea on glucose and lipid metabolism disorders in high-fat diet-fed mice
Obesity and its associated metabolic disorders constitute a major and growing global health challenge, creating an urgent need for safe and effective dietary interventions. Chongqing Tuo Tea, a traditionally compressed tea produced from summer-autumn leaves, has a distinctive chemical profile…
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Journal Article
Metabolomic study on the inhibitory effect of soluble dietary fiber from foxtail millet on colorectal cancer
Colorectal cancer (CRC) is a malignant tumor of the digestive tract, and previous studies demonstrated that soluble dietary fiber from foxtail millet (FMB-SDF) exhibits significant anti-colorectal cancer effects both in vivo and in vitro. However, the metabolic changes of FMB-SDF in colorectal…
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Journal Article
A polysaccharide from Artocarpus heterophyllus Lam. pulp ameliorates oxidative stress and lipid accumulation in HepG2 cells
Oxidative stress and hepatic lipid accumulation are two key contributors to the development of non-alcoholic fatty liver disease (NAFLD). The present research sought to examine the effect of a polysaccharide from Artocarpus heterophyllus Lam. pulp (JFP-Ps) on alleviating hydrogen peroxide…
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Journal Article
Effects of consumption of selenium biofortified milk on antioxidant and inflammatory biomarkers in children with autism spectrum disorder: A controlled, single-blind intervention study
Children with Autism Spectrum Disorder (ASD) often exhibit food selectivity, which may be associated with inadequate Selenium (Se) intake and imbalances in serum levels of enzymatic and non-enzymatic antioxidants as well as inflammatory cytokines. Several studies suggest an association between…
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Journal Article
Tempeh and microalgae-fortified tempeh exhibit anticancer potential through S-phase arrest and EGFR/PI3K/AKT/mTOR pathway modulation in BT-474 breast cancer cells
Tempeh, a traditional fermented soybean product, is valued for its nutritional and functional properties. Its health benefits can be enhanced through fortification. The diverse anticancer activities of microalgae pose a promising option for tempeh fortification. This study investigated the…
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Journal Article
Erythritol as a functional food ingredient mitigates heat-induced renal injury in mice via integrated metabolomic and transcriptomic analysis
Global warming increases the risk of heat-related renal impairment, while higher ambient temperatures may increase overall fluid and beverage consumption to meet hydration demands. As erythritol is widely used as a dietary sweetener in food and beverage products and is primarily excreted via the…
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Journal Article
Zingiber officinale Roscoe (ginger) extract alleviates age-induced hepatic lipid profile change in rats during ageing
Lipid metabolism undergoes significant alterations with age, contributing to the onset of age-related diseases. Ginger (Zingiber officinale Roscoe) is known for its antioxidant and anti-inflammatory properties, but its effect on hepatic lipid profiles during ageing remains unclear. This study aimed…
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Journal Article
Heat-killed Bifidobacterium longum LB-P23 ameliorates metabolic dysfunction in high-fat and high-sucrose diet-fed mice through gut microbiota modulation
The gut microbiota plays a pivotal role in obesity and metabolic disorders. This study evaluated the anti-obesity effects of heat-killed Bifidobacterium longum LB-P23 in a high-fat, high-sucrose diet-induced obese mouse model. Mice received low (1 × 108 TCC) or high (1 × 109 TCC) doses of B. longum…