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Epigenetics & Chromatin
Scopus
ISSN 1756-8935 · BMC · 653 articles in the index
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Journal Article
Daphnia magna diapause-interrupted embryogenesis has changes in histone modifications at H3K9
Abstract As a key component of freshwater ecosystem, Daphnia survives environmental challenges by entering a state of developmental arrest known as diapause. Diapause is not simply a sudden halt in growth and development, but a genetically regulated program involving a sequence of coordinated…
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Journal Article
DNA variants affecting chromatin structure are key to the genetic architecture of obsessive compulsive disorder
Abstract Background Obsessive Compulsive Disorder (OCD) affects 2 to 3% of the population and is marked by intrusive thoughts and repetitive behaviours. OCD is increasingly recognized as a polygenic disorder involving gene-environment interactions, with genetic risk largely driven by common…
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Journal Article
Interaction of serotonin transporter and TGFB1 facilitates histone serotonylation-mediated synaptic plasticity following environmental enrichment in stressed mouse Mus booduga
Abstract Background Environmental enrichment (EE) has been used as a non-pharmacological intervention to facilitate neurotransmission and improve neurobehaviour. In this study, we examined whether EE improves learning and memory in mice subjected to social isolation (SI)-induced stress through…
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Journal Article
CancerSubtyper: a deep learning framework for cancer subtyping through DNA methylation data
Abstract Background Molecular subtyping is essential for precision oncology, enabling the classification of tumors into biologically and clinically relevant categories. DNA methylation has emerged as a promising biomarker for cancer subtyping, yet its application remains limited by high…
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Journal Article
Human Alu loci gain enhancer-type epigenetic modifications in monocytes during response to bacterial LPS
Abstract Background Bacterial lipopolysaccharide (LPS) potently activates innate immunity. Transposable elements (TEs), particularly lineage-specific short interspersed elements (SINEs), have been implicated in immune regulatory evolution, yet their epigenomic roles during immune activation remain…
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Journal Article
Contributions of DNA mechanics and trans-regulation to nucleosome positioning in Schizosaccharomyces pombe and its role in co-transcriptional splicing
Abstract Background Nucleosome positioning critically regulates chromatin functions, yet species-specific mechanisms remain incompletely understood. This study revisits nucleosome organization in Schizosaccharomyces pombe ( S. pombe) using a DNA deformation energy model and a high-resolution…
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Journal Article
The impact of fulvestrant on estrogen receptor-driven chromatin dynamics in breast cancer cells
Abstract Background Epigenetic dysregulations are linked to several diseases, including cancer. Among them, breast cancer is the second leading cause of cancer-related deaths in women, with 50% of mortalities attributable to estrogen receptor-positive (ER +) tumors. Endocrine therapies targeting…
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Journal Article
Loss of maternal PADI6 disrupts DNA methylation and genomic imprinting maintenance in late preimplantation mouse embryos
Abstract Background The maternal-effect protein PADI6, which is part of the subcortical maternal complex, is involved in proper spindle assembly, organelle distribution, ribosome storage, and cytoplasmic lattice organization in mouse oocytes. In humans, variants of PADI6 are associated with female…
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Journal Article
Integrating single-cell transcriptomics and epigenetics in a multi-omics MR framework identifies PARK7 as a causal gene in streptococcal septicemia
Abstract Background Streptococcal septicemia is associated with high mortality and morbidity, yet the underlying epigenetic mechanisms, particularly those involving mitochondrial genes, remain poorly understood. This study employed a multi-omics Mendelian randomization (MR) framework to investigate…
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Journal Article
Epigenetic deciphering of ovarian aging: multilayer interactive mechanisms and targeted reversal strategies
Abstract Ovarian aging leads to the progressive loss of reproductive and endocrine functions. As an upstream regulatory hub, epigenetic modifications synergistically impair these two functions through multi-dimensional mechanisms, collectively contributing to the occurrence of clinical phenotypes…
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Journal Article
Temporal stratification of promoter-proximal versus enhancer VDR binding directs vitamin D-responsive transcription
Abstract Background The active vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) activates the vitamin D receptor (VDR) in immune cells, altering the epigenome to drive diverse responses. However, how the temporal dynamics, genomic positioning, and inducibility of VDR binding are…
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Journal Article
Pathway-level epigenetic modeling illuminates the methylation architecture to asthma risk across tissues
Abstract Background Asthma is a clinically heterogeneous airway disorder characterized by complex interactions between environmental exposures, immune activation, and molecular regulatory programs, whose underlying mechanisms are not fully elucidated by known genetic loci. DNA methylation serves as…
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Journal Article
The marsupial imprinted gene MLH1 has retrocopies in three marsupial families
Abstract Background The mut-L homologue 1 gene (MLH1) is a DNA repair gene. Loss of biallelic expression of MLH1 in humans leads to increased predisposition to several cancer types. In the koala (Phascolarctos cinereus) and brushtail possum (Trichosurus vulpecula), MLH1 is imprinted, resulting in…
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Journal Article
From two to one: spatiotemporal mapping of chromatin remodelling in the protamine-lacking early zygote of zebrafish
Abstract Background At fertilization, two highly specialized gametic genomes must rapidly reprogram into a single totipotent nucleus. In mammals, this transformation is marked by a dramatic protamine-to-histone exchange and pronounced asymmetry between the parental pronuclei. Zebrafish offer a…
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Journal Article
Role of LDHA in senescent fibroblast exosomes promoting ferroptosis via histone lactylation-mediated ACSL4 regulation in skin photoaging
Abstract Objective This study aimed to elucidate the mechanism of Lactate Dehydrogenase A (LDHA) in senescent fibroblast-derived exosomes during skin photoaging, focusing on the molecular pathway by which it regulates Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) expression through histone…
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Journal Article
Delineating SWI/SNF gene and subtype expression in cancer
Abstract Background Approximately 20% of all cancers contain mutations in genes coding for components of the SWI/SNF chromatin remodeling complex, which exists in three main subtypes: cBAF, PBAF, and GBAF. Mutations in SWI/SNF genes may disrupt chromatin remodeling and deregulate epigenetic…
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Journal Article
Epigenetic and chromatin remodeling mechanisms across cardiomyopathies: a comprehensive review
Abstract Cardiomyopathies constitute a heterogeneous group of myocardial disorders representing leading causes of heart failure and cardiovascular mortality worldwide. While genetic mutations have been extensively characterized across different cardiomyopathy subtypes, the mechanistic links between…
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Journal Article
Drosophila Rumpelstiltskin regulates Polycomb cis and trans interactions and Homie barrier activity
Abstract Background Three-dimensional genome organization is maintained in part by chromatin insulators, DNA–protein complexes that create boundaries between active and inactive chromatin and regulate enhancer-promoter interactions. In Drosophila, the Homing insulator at eve (Homie) sequence…
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Journal Article
H1.3 depletion in AML cells prompts H1.2 redistribution, chromatin remodeling and cell cycle defects
Abstract Linker histone H1 variants play critical, yet distinct, roles in chromatin organization and gene regulation. However, their specificity in cancer cells is not well understood. Our previous studies have shown that acute myeloid leukemia (AML) patients who were H3K27me3HIST1-positive…
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Journal Article
Host-cell dependent epigenetic profiles associated with survival outcomes in T. gondii infection
Abstract Toxoplasmosis is a widespread parasitic disease affecting roughly one-third of the global population. In immunocompromised individuals or during pregnancy, infection can result in severe complications. Following primary infection, Toxoplasma gondii forms dormant bradyzoite cysts in tissues…