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Gut Pathogens
Scopus
ISSN 1757-4749 · BMC · 787 articles in the index
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Journal Article
Clinical and microbial correlates of response to lifestyle intervention in pediatric metabolic dysfunction-associated steatotic liver disease
Abstract Background Lifestyle modifications are fundamental in managing metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to evaluate the effects of a 12-week lifestyle intervention on hepatic steatosis, liver function, and gut microbiota composition in pediatric…
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Journal Article
Microbial modulators of the epigenome: probiotic regulation of MiRNAs and LncRNAs in health and disease and preventive medicine
Abstract Current improvements in microbiome research have illuminated the serious function of probiotics in modulating host gene expression through epigenetic mechanisms, particularly via the regulation of non-coding RNAs (ncRNAs) such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). These…
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Journal Article
Broad-spectrum antibiotic treatment reshapes the gut microbiome, resistome, and colonization potential of opportunistic pathogens: a metagenomics study
Abstract Background The gut microbiota (GM) harbors diverse antibiotic resistance genes (ARGs), which are primarily disseminated through horizontal gene transfer (HGT), contributing to the emergence and spread of multidrug-resistant (MDR) pathogens. Broad-spectrum antibiotics are commonly used to…
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Journal Article
Metagenomic analysis of the human gut virome reveals functional signatures and viral stability across hospitalized and non-hospitalized diarrheal and non-diarrheal individuals
Abstract Background The human gut virome is a fundamental yet understudied component of the intestinal microbiome. However, its taxonomic composition and functional potential in Latin American populations remain poorly understood, particularly under clinical stressors such as hospitalization and…
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Journal Article
Shigella flexneri 1c bacteremia in a child: a case report
Abstract Background Shigellosis is a significant public health issue in developing countries, particularly affecting young children under the age of five. While it primarily causes gastrointestinal infections, there are rare complications, such as bacteremia, that mainly occur in young children. We…
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Journal Article
Modulatory role of Akkermansia muciniphila in cancer pathophysiology: a systematic review and meta-analysis of preclinical studies
Abstract Akkermansia muciniphila (A. muciniphila), a health-promoting bacterium in the human gut, is recognized for its role in improving immune function and metabolic health. Recent studies have uncovered its potential use as a therapeutic intervention for cancer treatment. This meta-analysis…
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Journal Article
Assessing whether rectal swabs reflect appendiceal microbiota profiles in acute appendicitis: a 16S rRNA-based comparative study
Abstract Background Acute appendicitis is associated with characteristic changes in the intestinal microbiota, but direct sampling of appendiceal contents is invasive and cannot be performed in healthy controls. We therefore evaluated whether rectal swabs could partially capture appendiceal…
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Journal Article
Sodium butyrate augments the antibacterial activity of tetracycline against clinical isolates of multidrug-resistant Vibrio cholerae
Abstract Background Antibiotic resistance poses a major challenge in treating Vibrio cholerae infections. One promising method to counter resistance is the co-administration of antibiotics with non-antibiotic adjuvants to enhance their efficacy. This study investigated the combined action of sodium…
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Journal Article
Gut microbiome-based strategies for HIV prevention and therapy, current challenges and future prospects
Abstract The gut microbiome has become a primary controller of host immunity as well as the pathogenesis of human immunodeficiency virus (HIV) infection. Commensal microbes in healthy persons keep the intestinal and other body barriers intact and regulate mucosal and systemic immune responses and…
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Journal Article
Species-level dynamics of gastric microbiome after Helicobacter pylori eradication in high-risk Mongolian population
Abstract Background Species-level resolution is essential to understand gastric microbiome recovery after Helicobacter pylori eradication, yet short-read 16 S rRNA approaches often obscure clinically relevant changes. Methods Gastric biopsies from 121 adults in Bayan-Ölgii, Mongolia (71 H…
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Journal Article
Multi-aspect therapeutic effects of a polyphenolic herbal formulation Cirsium japonicum, Scutellaria baicalensis, Paeonia japonica, and Glycyrrhiza uralensis on ulcerative colitis: inflammation modulation, gut microbiota remodeling, and metabolite profiling
Abstract Ulcerative Colitis (UC) is a chronic illness that commonly demands the use of medication, sometimes for long term. In a DSS mouse model, we examined 5-aminosalicylic acid (5ASA) in comparison to a defined polyphenol-rich herbal mixture CSPG: Cirsium japonicum, Scutellaria baicalensis…
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Journal Article
Tropical sprue: a narrative review of a neglected malabsorption syndrome
Abstract Tropical sprue, a rare malabsorption syndrome, remains a significant yet underrecognized gastrointestinal disorder endemic to tropical regions, including South and Southeast Asia (e.g., India, Pakistan) and Caribbean islands (e.g., Puerto Rico, the Dominican Republic, Haiti). Its etiology…
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Journal Article
Enhanced pathogen detection and gut microbiome alterations in pyogenic liver abscess: insights from next-generation sequencing
Abstract Objectives Pyogenic liver abscess (PLA) is a life-threatening infection with high mortality in Asia. Although Klebsiella pneumoniae is commonly implicated, emerging data suggest a more diverse microbial spectrum. This study investigated pathogen detection using conventional culture and…
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Journal Article
Contrasting the gut microbiome in Colombian patients with diarrhea: a comparative metagenomic study in hospitalization and emergency room services
Abstract Background Diarrhea remains a major cause of morbidity worldwide, particularly in low- and middle-income countries. Hospital environments impose strong selective pressures on the gut microbiome through antimicrobial exposure, invasive procedures, and pathogen transmission, yet differences…
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Journal Article
Feco-prevalence and risk factors of Helicobacter pylori infection among adults with dyspepsia in Mogadishu, Somalia: a cross-sectional study
Abstract Background Helicobacter pylori is one of the most prevalent bacterial infections in humans, affecting more than half of the global population. It is a major contributor to gastric disorders among patients attending gastroenterology clinics. Therefore, this study aimed to evaluate the fecal…
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Journal Article
Levofloxacin-based concomitant versus sequential therapy for Helicobacter pylori eradication in treatment-naïve Syrian patients: a randomized trial showing no superiority of sequential therapy
Abstract Background Helicobacter pylori (H. pylori) infection remains highly prevalent worldwide, including the Eastern Mediterranean region. In Syria, standard triple therapy effectiveness has declined due to increasing antibiotic resistance, misuse, and healthcare limitations. As…
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Journal Article
Insights into the dynamics of antibiotic resistance genes in the human gut microbiome across populations
Abstract The human microbiome serves as a reservoir of antibiotic resistance genes (ARGs), collectively known as the resistome, which has crucial implications for human health. However, the distribution of ARGs across diverse bacterial taxa and their variation across populations, disease states…
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Journal Article
Serial serum interleukin-8 trajectories are associated with progression from Helicobacter pylori–associated precancerous lesions to gastric cancer: a prospective longitudinal cohort study
Abstract Background Gastric cancer remains the fourth leading cause of cancer-related mortality worldwide, with delayed diagnosis contributing to poor prognosis. Current biomarkers lack sensitivity for early detection. Interleukin-8 (IL-8), a pro-inflammatory chemokine implicated in H…
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Journal Article
Cytomegalovirus gastritis in an immunocompetent host: insights into gut viral pathogenesis and mucosal barrier disruption
Abstract Background Cytomegalovirus (CMV) is a ubiquitous herpesvirus and an important, often underappreciated, viral pathogen of the gastrointestinal tract.Although CMV infection is typically asymptomatic in immunocompetent individuals, gastric involvement, a rare manifestation of gut CMV disease…