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Stem Cell Research & Therapy
Scopus
ISSN 1757-6512 · BMC · 4.630 artikel di indeks
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Artikel Jurnal
Safety profile of autologous adipose-derived stromal vascular fraction in clinical use: an exhaustive literature review
Abstract Adipose tissue–derived stromal vascular fraction (SVF) has rapidly emerged as a promising tool in regenerative medicine due to its accessibility, autologous origin, and potent reparative potential. However, despite encouraging preclinical outcomes, the clinical safety of SVF across organ…
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Artikel Jurnal
A serum-free culture medium for long-term expansion of human airway basal stem cells
Abstract Background Human basal stem cells, with their self-renewal and multilineage differentiation capacity, are essential tools for modeling airway diseases and advancing regenerative medicine. However, existing culture systems often rely on undefined components like serum, bovine pituitary…
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Artikel Jurnal
Extracorporeal cardiac shock wave stimulation enhances the therapeutic efficacy of intravenously delivered endothelial colony-forming cells via PI3K/AKT signaling in a rat myocardial infarction model
Abstract Background Extracorporeal cardiac shock wave (ECSW) therapy enhances the function of endothelial colony-forming cells (ECFCs), but whether it can serve as a preconditioning strategy to enhance myocardial infarction (MI) therapy remains unclear. This study investigated the efficacy and…
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Artikel Jurnal
Human umbilical mesenchymal stem cell-derived mitochondria transplantation suppresses sFLT-1 secretion by regulating calcineurin-NFAT-dependent pathways in angiotensin II-induced preeclampsia rats
Abstract Background Mitochondrial transplantation (Mito-T) is a novel therapeutic strategy for ischaemic cardiovascular diseases. This study aimed to test the efficacy of human umbilical mesenchymal stem cell-derived mitochondrial transplantation (Mito-T) on preeclampsia (PE). Methods PE was…
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Artikel Jurnal
OSBPL2-mediated lipid metabolism alteration governs lung cancer stem cells properties
Abstract Lung cancer is the first leading cause of cancer death worldwide. oxysterol-binding protein-like 2 (OSBPL2), is a lipid transport protein regulating cholesterol homeostasis. Here, we clarified the previously unreported role of OSBPL2 in lung cancer stemness properties. We observed that…
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Artikel Jurnal
Apoptotic vesicles from endothelial cells promote endothelial progenitor cell differentiation and angiogenesis via miR-30a-5p mediated activation of the EGFR/PI3K/AKT/VEGF pathway
Abstract Background Endothelial cells (ECs) are crucial for tissue repair and wound healing but are prone to damage and apoptosis. When tissues or blood vessels are injured, endothelial progenitor cells (EPCs) are quickly activated, home to the site, and differentiate into ECs for endothelial…
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Artikel Jurnal
Retinoblastoma: unveiling molecular pathogenesis and pioneering organoid-driven therapeutic innovations
Abstract Retinoblastoma (RB), which is the most common pediatric intraocular malignancy driven by RB1 inactivation, presents with clinical challenges, such as treatment toxicity, relapse, and resistance. Traditional models inadequately replicate human RB genetics or tumor heterogeneity, warranting…
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Artikel Jurnal
Therapeutic efficacy of extracellular vesicles from hiPSC-derived MSCs in serum-containing and xeno-free media for osteoarthritis treatment
Abstract Background Extracellular vesicles derived from human induced mesenchymal stromal cells (hiEVs) constitute a promising cell-free therapeutic option for osteoarthritis. To facilitate transition to the clinic we evaluated the therapeutic effects of hiEVs for osteoarthritis treatment…
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Artikel Jurnal
Enhanced proliferation tracer reveals Dorsal-Ventral asymmetry in tracheal epithelial Renewal
Abstract To elucidate spatiotemporal dynamics of tissue renewal, we developed evProTracer, an enhanced dual-recombinase lineage tracing system for cumulative in vivo labeling of proliferating cells. Robust longitudinal tracing using evProTracer in murine tracheal epithelium revealed near-complete…
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Artikel Jurnal
Mesenchymal stromal cells alleviate pulmonary arterial hypertension by suppressing pulmonary arterial adventitial fibroblast activation and extracellular matrix remodeling via the SOCS3/STAT3 pathway
Abstract Background Pulmonary arterial hypertension (PAH) is a fatal condition characterized by progressive vascular remodeling in the pulmonary arteries, eventually leading to right heart failure and death. Dysregulated extracellular matrix (ECM) remodeling is central to PAH pathogenesis and…
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Artikel Jurnal
Deficiency of extracellular vesicles miR-32 from bone marrow mesenchymal stem cells alleviates vascular calcification in type 2 diabetes by inhibiting endothelial ferroptosis
Abstract Background The development of vascular calcification (VC) in diabetes is closely related to the endothelial-to-mesenchymal transition (EndMT). We found that microRNA-32-5p (miR-32) was elevated in the plasma of calcification patients. However, it is unclear whether miR-32 mediates the…
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Artikel Jurnal
Molecular and functional characterization of GMP-manufactured neural stem cells and their extracellular vesicles for innovative therapeutic applications
Abstract Human neural stem cells (hNSCs) are promising candidates for regenerative medicine due to their self-renewal capacity, differentiation potential, and ability to modulate inflammation. However, several reports showed that the regenerative properties of stem cells are tied to the…
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Artikel Jurnal
Immunomodulatory effect of mesenchymal stromal cell overexpressing HLA-G1 in cell-based therapy for myocardial infarction
Abstract Background Our previous study revealed that intravenous administration of mesenchymal stromal cells (MSCs) increases local cell engraftment and improves heart function. This study aims to investigate whether MSCs overexpressing HLA-G1 have further increased local transplanted cells…
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Artikel Jurnal
HucMSC-derived exosomes alleviate chemotherapy-induced premature ovarian insufficiency via SMURF1-mediated inhibition of ferroptosis in ovarian granulosa cells
Abstract Background Human umbilical cord mesenchymal stem cell-derived exosomes (HucMSC-Exo) have shown great therapeutic promise in the treatment of primary ovarian insufficiency (POI). Ferroptosis, a distinct form of cell death, has been associated with the pathogenesis of POI. However, whether…
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Artikel Jurnal
Mesenchymal stem cell-derived extracellular vesicles in musculoskeletal regeneration: mechanisms, applications, and future prospects
Abstract Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as promising cell-free therapeutic strategies for musculoskeletal regeneration. MSC-EVs, which are enriched with diverse cargos, exert multifaceted biological effects, including the modulation of inflammation, the…
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Artikel Jurnal
Exosomal miRNA–mRNA interactions highlight MSC-like molecular signatures in dental pulp fibroblasts
Abstract Background Exosomes derived from mesenchymal stem cells (MSCs) are increasingly recognized as promising mediators of tissue regeneration. However, most studies have focused on exosomes from purified MSC populations, and the regenerative relevance of exosomes secreted by fibroblast-dominant…
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Artikel Jurnal
Hybrid endometrial-derived hydrogel and human endometrial organoids synergize for uterine regeneration in an immunocompetent murine model
Abstract Background The human endometrium is a regenerative tissue essential for fertility, but pathological conditions like Asherman syndrome, endometrial atrophy, and thin endometrium can impair its function. Current therapies lack efficacy, driving demand for innovative regenerative therapies…
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Artikel Jurnal
Klotho protects the osteogenic function of human periodontal ligament stem cells in periodontitis by inhibiting NOX4-mediated ferroptosis
Abstract Background Periodontitis, the leading cause of tooth loss worldwide, is closely linked to the compromised regenerative capacity of human periodontal ligament stem cells (hPDLSCs). Stem cell-based tissue engineering is a promising treatment for periodontitis. Sustaining the osteogenic…
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Artikel Jurnal
CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation
Abstract Background Ovarian aging (OA), which is characterized by a decline in the quality and quantity of oocytes, represents a major challenge in reproductive medicine. However, the therapeutic targets and therapeutic methods of OA remain poorly defined. Previous studies have suggested that the…
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Artikel Jurnal
FHOD3 deficiency disrupts sarcomere organization and activates caMKII signaling in human stem cell-derived cardiomyocytes
Abstract Background Inherited cardiomyopathy (ICM) is a genetic disorder characterized by abnormal myocardial structure and function, often progressing to heart failure. FHOD3, a member of the Formin gene family, plays a crucial role in cardiomyocyte cytoskeletal organization. Mutations in FHOD3…
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