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Diabetology & Metabolic Syndrome
Scopus
ISSN 1758-5996 · BMC · 2.200 artikel di indeks
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Artikel Jurnal
Duodenal mucosal intervention in the management of MASLD and type 2 diabetes
Abstract Background The pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes mellitus (T2DM) is rooted in the gut-liver axis dysfunction. To enhance glycemic control and liver fat level, new duodenal mucosal ablation procedures, such as duodenal…
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Artikel Jurnal
Methodological and statistical errors distort the effects of glucagon-like peptide-1 receptor agonist drugs on body composition in patients with type 2 diabetes mellitus
Abstract In August of 2025, Wang and colleagues published a systematic review and meta-analysis quantifying the effects of glucagon-like peptide-1 receptor agonist (GLP1RA) drugs on skeletal muscle mass in patients with type 2 diabetes mellitus. This paper is of considerable clinical importance, as…
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Artikel Jurnal
Repurposing GLP-1 receptor agonists for alcohol use disorder: a systematic review and meta-analysis
Abstract Background Alcohol use disorder (AUD) affects nearly half a billion people globally and is associated with significant physical and psychiatric comorbidities. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), approved for diabetes and obesity, have shown promise in modulating…
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Artikel Jurnal
Impact of Cilostazol versus Cilostazol and Selenium Combination on The Healing of Diabetic Foot Ulcer Patients: A Randomized Controlled Trial
Abstract Background Diabetic foot ulcer (DFU) is a debilitating complication of diabetes mellitus (DM). This study aimed to compare the impact of cilostazol alone or with selenium on wound healing in non-ischemic DFU patients. Methods A randomized controlled trial was conducted on 69 DFU patients…
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Artikel Jurnal
A U-shaped association between vitamin D and ketone levels in type 2 diabetes: a metabolic state–dependent dual regulation mechanism
Abstract Background Beyond bone health, vitamin D plays a pivotal role in glucose and lipid homeostasis. Vitamin D deficiency is prevalent in type 2 diabetes (T2DM), potentially exacerbating β-cell dysfunction and dysregulated energy substrate utilization. This study aimed to characterize the…
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Artikel Jurnal
Myocardial ischemia reperfusion in diabetes: mechanism of injury and its drug treatment
Abstract Diabetes with myocardial ischemia-reperfusion injury(MIRI) represents a common complication of diabetes mellitus (DM), and cardiovascular disease remains the leading cause of death in DM patients. Consequently, preventing cardiovascular disease in individuals with diabetes continues to…
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Artikel Jurnal
Social, psychosocial, and lifestyle determinants of diabetes and prediabetes in US adults before and after COVID-19: a cross-sectional NHANES analysis
Abstract Background Type 2 diabetes and prediabetes are increasingly shaped by social, psychological, and lifestyle determinants beyond traditional biomedical risk factors. The COVID-19 pandemic profoundly disrupted these determinants. We aimed to assess, using a comparative cross-sectional…
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Artikel Jurnal
Association between the remnant cholesterol and the risk of new-onset chronic diseases: evidence from CHARLS
Abstract Background Remnant cholesterol (RC), a key component of triglyceride-rich lipoproteins, is an established predictor of atherosclerotic cardiovascular disease. However, its longitudinal associations with the development of a broad spectrum of other chronic diseases, particularly in…
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Artikel Jurnal
Association of glycemic variability with the risk of new-onset atrial fibrillation and death in critically ill patients without diabetes: analysis of the MIMIC-IV database
Abstract Background Glycemic variability (GV), a prevalent phenomenon of abnormal blood glucose levels in intensive care unit (ICU) is correlated with cardiac arrhythmias and in-hospital mortality. The specific link between GV and new-onset atrial fibrillation (AF), as well as in-hospital…
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Artikel Jurnal
Hepatorenal vulnerability flagged by glomerular hyperfiltration in metabolic liver disease: a large health-screening cohort evidence
Abstract Background The interplay between glomerular hyperfiltration (GHF) and downstream renal dysfunction and hepatic fibrosis in metabolic dysfunction–associated steatotic (or fatty) liver disease (MASLD or MAFLD) remains insufficiently understood. We investigated these associations in a large…
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Artikel Jurnal
Lipid metabolism–inflammation crosstalk and risk of incident cancer, cardiovascular diseases, and stroke among individuals with prediabetes: findings from a nationwide, population based, prospective cohort study
Abstract Background Prediabetes is a well-established risk factor for cardiovascular diseases (CVD), stroke, and cancer, but whether this risk is uniform across all individuals remains uncertain. Additionally, heterogeneity within the prediabetic population, driven by mechanisms like lipid…
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Artikel Jurnal
Prevalence and risk factors of metabolic syndrome in survivors of childhood acute leukemia: a systematic review and meta-analysis
Abstract Background Metabolic syndrome (MetS) is associated with an increased risk of cardiovascular disease and has also been associated with malignancies including leukemia. This systematic review and meta-analysis aimed to assess the prevalence of metabolic syndrome (MetS) and its core…
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Artikel Jurnal
Empagliflozin and its impact on hepatic and metabolic outcomes in patients with type 2 diabetes and NAFLD: a systematic review and meta-analysis
Abstract Background Metabolic dysfunction–associated steatotic liver disease (MASLD), formerly nonalcoholic fatty liver disease (NAFLD), often coexists with type 2 diabetes mellitus (T2DM) due to shared metabolic pathways such as insulin resistance. Empagliflozin, a sodium-glucose cotransporter-2…
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Artikel Jurnal
Impact of admission hyperglycemia on clinical outcomes in patients with acute large ischemic stroke undergoing endovascular treatment
Abstract Background This study aimed to explore the impact of admission hyperglycemia on clinical outcomes in patients with acute large ischemic stroke undergoing endovascular treatment (EVT). Methods Patients with admission blood glucose levels were obtained from a prospective cohort study. We…
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Artikel Jurnal
Comparative risk of gestational diabetes mellitus following fresh and frozen embryo transfers: a retrospective cohort study in Palestinian women undergoing in vitro fertilization
Abstract Background Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy and is increasingly recognized among women conceiving through assisted reproductive technology (ART). However, whether the type of embryo transfer fresh or frozen affects GDM risk remains…
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Artikel Jurnal
Aerobic exercise training attenuates cardiac inflammation and fibrosis in mice with type 2 diabetes and inhibits the advanced glycation end products pathway
Abstract Background Type 2 diabetes mellitus (T2D) is associated with cardiac dysfunction caused by oxidative stress, inflammation, and fibrosis. Exercise has shown cardioprotective effects in T2D. However, the impact on the Advanced Glycation End Products (AGE) and its receptors remains unclear…
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Artikel Jurnal
Infection trajectories and dementia risk in type 2 diabetes
Abstract Background Dementia poses a significant global health burden, with rising prevalence and substantial economic and social costs. Type 2 diabetes mellitus (T2DM) is a well-established risk factor for dementia, yet the impact of recurrent infections—a common complication in T2DM—on dementia…
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Artikel Jurnal
The application of AI-based interventions in diabetes personalized management: a systematic review and meta-analysis
Abstract Background Artificial intelligence (AI)–based interventions are increasingly integrated into diabetes management, but the certainty of their clinical benefits remains uncertain. Methods We conducted a systematic review and meta-analysis of 13 studies assessing AI-based interventions for…
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Artikel Jurnal
Insulin-resistance indices and cardiovascular mortality in cardiovascular–kidney–metabolic syndrome stage 2: a comparative analysis of eGDR, TyG and METS-IR
Abstract Background Cardiovascular–kidney–metabolic syndrome stage 2 (CKM–S2) markedly elevates cardiovascular mortality. Insulin-resistance (IR) surrogates—including the triglyceride-glucose (TyG) index, metabolic score for insulin resistance (METS-IR) and estimated glucose-disposal rate…
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Artikel Jurnal
Acute renoprotective effects of dapagliflozin monotherapy on albuminuria and metabolic derangements in newly diagnosed type 2 diabetes mellitus: a quasi-experimental study
Abstract Background Diabetic kidney disease (DKD) is a globally prominent microvascular sequela of Type 2 Diabetes Mellitus (T2DM), making effective early prevention paramount. The well-established cardiorenal benefits of sodium-glucose co-transporter 2 inhibitors (SGLT2i) are largely derived from…
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