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Alzheimer’s Research & Therapy
Scopus
ISSN 1758-9193 · BMC · 1.888 artikel di indeks
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Artikel Jurnal
Semantic fluency predicts survival of memory clinic patients
Abstract Background Semantic fluency is commonly assessed in the diagnostic work-up of individuals with suspected cognitive impairment due to neurodegenerative disease. Semantic fluency has a predictive value for survival in clinical AD and in healthy elderly individuals, but it is unknown if this…
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Artikel Jurnal
Longitudinal changes of blood β-synuclein in cognitively unimpaired, mild cognitive impairment and sporadic Alzheimer´s disease
Abstract Background β-Synuclein is an emerging synaptic blood biomarker for Alzheimer´s disease (AD) and correlates with cognitive impairment, brain atrophy and amyloid/tau pathology. Longitudinal data from individual patients are missing so far but are important to evaluate how changes of…
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Artikel Jurnal
Ratios of CSF proteins reflect cognitive function in ALS
Abstract Background Cognitive impairment is a recognised feature of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Despite advances in understanding cognitive impairment in ALS, no fluid biomarkers reliably predict these changes. Prior research in Alzheimer disease (AD)…
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Artikel Jurnal
A new paradigm for stratified cognitive assessment: fusing serum Raman spectroscopy and ensemble learning
Abstract Background In China, the growing need for stratified cognitive assessment demands portable solutions. However, in community-based screening, neuropsychological assessments suffer from low acceptance and low efficiency. Thus, we aimed to develop a serum Raman spectroscopy-based ensemble…
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Artikel Jurnal
Reduced serum AHR agonistic activity reflects amyloid dysregulation in AT1 subtypes of Alzheimer’s disease
Abstract Background The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor linking environmental signals to immune regulation and neurodegeneration. While AHR agonists exert protective effects in Alzheimer’s disease (AD) models, their relevance in humans remains unclear. We…
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Artikel Jurnal
Interactive effect of retinal microvascular impairment and larger lesion diameter on cognitive impairment in lacunar infarction
Abstract Background Lacunar infarction (LI), a subtype of ischemic stroke caused by cerebral small vessel disease (SVD), is strongly associated with post-stroke cognitive impairment (PSCI). While neuroimaging biomarkers are critical for diagnosis, their accessibility and cost limit routine use. The…
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Artikel Jurnal
Blood-based biomarkers for Alzheimer’s disease: influence of kidney function
Abstract Background Blood-based biomarkers are increasingly incorporated into the diagnostic work-up of Alzheimer’s disease (AD). Systemic conditions such as kidney dysfunction (KD) may influence their plasma concentrations and complicate clinical interpretation. While the association between KD…
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Are pre-frail and frail amyloid positive individuals eligible to Lecanemab? A cross-sectional analysis from the Cogfrail real-world cohort
Abstract Background Following the positive outcomes of the Clarity-AD trial, Lecanemab received marketing authorization from the European Medicines Agency (EMA) and is expected to become available across Europe. However, the trial did not specifically evaluate frailty, making it difficult to…
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Artikel Jurnal
Exploring neural correlates of automated speech-based cognitive markers through resting-state functional connectivity in aging and at-risk Alzheimer’s disease
Abstract Background Digital speech-based assessments provide scalable tools for detecting subtle cognitive decline. Here, we investigated whether digitally derived speech-based composite score of cognition and individual speech features were associated with alterations in functional connectivity…
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Artikel Jurnal
An RNA biomarker panel for the diagnosis of Alzheimer’s disease from whole blood
Abstract Background Alzheimer’s Disease (AD) diagnosis remains primarily clinical, relying on patient history, cognitive tests, and sometimes brain imaging. Emerging approaches include advanced neuroimaging techniques and the use of protein biomarkers in cerebrospinal fluid and plasma. However…
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Artikel Jurnal
Proof-of-concept study: APOE4 brain endothelial cells as a phenotypic compound screen
Abstract Background Published data suggest that compared to APOE3, APOE4 could increase the risk of neurodegeneration via higher cerebrovascular permeability. We recently proposed the concept that brain endothelial cell APOE is protective for cerebrovascular function in a genotype specific manner…
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Artikel Jurnal
Protective PLCG2 variants associate with a delayed onset of Alzheimer’s disease among heterozygous APOE ε4 carriers
Abstract Background The PLCG2-P522R variant, which encodes a mildly hyperactive form of the PLCγ2 enzyme, has been identified as a protective genetic factor against Alzheimer’s disease (AD). Many recently discovered AD-associated microglial risk genes converge on the TREM2-PLCγ2 signaling pathway…
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Artikel Jurnal
Sex and APOE ε4 genotype modify risk factor associations with cerebral amyloid angiopathy: a multi-cohort autopsy study
Abstract Background This study aimed to identify risk factors and develop statistical models to predict cerebral amyloid angiopathy (CAA). Methods Associations between demographic, cognition, cardiovascular, and AD-related neuropathology and CAA were analyzed using data from three longitudinal…
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Artikel Jurnal
Early aperiodic EEG changes in preclinical and prodromal Alzheimer’s disease
Abstract Background Alzheimer’s disease (AD) is characterized by a gradual buildup of beta amyloid (Aβ) and tau proteins, which disrupt the balance between neuronal excitation and inhibition (E-I), leading to dysfunction in neural network activity. In this study, we examined the aperiodic exponent…
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Artikel Jurnal
Circulating inflammatory proteins predict dementia risk, and are linked to structural brain changes and modifiable risk factors
Abstract Introduction Systemic inflammation has been identified as a key factor in neurodegeneration but the value of circulating inflammatory proteins in dementia risk prediction and their causal role has not been elucidated. Methods We leveraged proteomic data from 43,685 UK Biobank participants…
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Artikel Jurnal
Altered temporal dynamics of prefrontal ERP responses reflecting neural adaptation in patients with amnestic mild cognitive impairment
Abstract Background With increasing life expectancy, age-related cognitive disorders including mild cognitive impairment (MCI) represent major public health challenges, and amnestic MCI (aMCI) has the greatest risk of progression to dementia due to Alzheimer’s disease (AD). Event-related potentials…
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Artikel Jurnal
Real world clinical practice of lecanemab at PUMCH dementia cohort: focus on dynamic imaging and biomarker evolution
Abstract Background Lecanemab is an anti-Aβ antibody approved in China for mild cognitive impairment (MCI) and mild dementia. Real-world application requires comprehensive assessment beyond MMSE scores, considering factors like ARIA risk. This single-center, real-world study aims to evaluate its…
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Artikel Jurnal
When Alzheimer’s pathology meets cardiometabolic risk: intrinsic subcortical–cortical connectivity signatures of retroactive interference in aging
Abstract Background Retroactive interference (RI), the disruption of past memory by new information, has been proposed as a sensitive marker of early vulnerability in aging and Alzheimer’s disease (AD). Yet, its neural bases and links to cardiometabolic risk remain largely unknown. Here, we…
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Artikel Jurnal
Interpretable machine-learning prediction of PSEN1 missense variant pathogenicity based on multi-omics enrichment in six core Alzheimer’s disease genes
Abstract Background and objective The clinical interpretation of Alzheimer’s disease (AD) is frequently complicated by the prevalence of missense variants designated as being of uncertain significance within associated genes. Conventional computational prediction tools often overlook…
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