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Therapeutic Advances in Musculoskeletal Disease
Scopus
ISSN 1759-7218 · SAGE Publishing · 594 artikel di indeks
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Artikel Jurnal
Implementation of clinical decision support tools for treatment selection in knee osteoarthritis: a scoping review
Knee osteoarthritis (KOA) presents heterogeneous phenotypes, motivating a need for clinicians to deliver targeted therapies. There is a plethora of options that can be encompassed in KOA treatment regimes. Clinical decision support (CDS) tools that incorporate individual patient data have the…
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Artikel Jurnal
Real-world trajectories in psoriatic arthritis under risankizumab therapy
Background Risankizumab, a selective IL-23p19 inhibitor, has demonstrated efficacy in randomized clinical trials, but real-world data remain limited. Objectives To evaluate the real-world effectiveness and safety of risankizumab in PsA, and to identify baseline predictors of treatment response…
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Artikel Jurnal
Pitavastatin use and risk of osteoporosis and osteoporotic fractures: A nationwide retrospective cohort study
Background Osteoporosis and dyslipidemia share overlapping pathophysiological mechanisms, and statins have been suggested to exert pleiotropic effects on bone metabolism. However, the comparative skeletal impact of individual statins, particularly pitavastatin, remains insufficiently characterized…
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Artikel Jurnal
Dynamics and clinical determinants of QuantiFERON-TB gold status changes in patients with inflammatory arthritis receiving TNF-α inhibitors
Background Screening and longitudinal monitoring for latent tuberculosis infection (LTBI) using interferon-gamma release assays (IGRAs), such as QuantiFERON-TB Gold (QFT), are mandatory during tumor necrosis factor-alpha (TNF-α) inhibitor therapy. However, the long-term dynamics of serial QFT…
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Artikel Jurnal
Cost-effectiveness analysis of X-ray- and MRI-based diagnostic pathways in axial spondyloarthritis
Background Diagnostic imaging plays a central role in the diagnosis of axial spondyloarthritis (axSpA). Current guidelines recommend a stepwise imaging approach, starting with X-ray and, in negative cases, following with magnetic resonance imaging (MRI), are increasingly questioned. Objectives The…
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Artikel Jurnal
The paradox of osteoporosis in axial spondyloarthritis: Why antiresorptives may not be enough and anabolic therapy could be prioritized
Osteoporosis (OP) in radiographic axial spondyloarthritis (r-axSpA) exhibits a paradoxical mechanism. Chronic inflammation driven by pro-inflammatory cytokines (TNF-α, IL-17A/F, and IL-23) leads simultaneously to accelerated trabecular bone resorption with deterioration of bone microarchitecture…
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Artikel Jurnal
Ultrasound-mediated cavitation of microbubble-infused dressings increases the therapeutic efficacy of piroxicam gel for hand arthritis: An intraindividual randomized controlled trial
Background Combining ultrasound (US) with microbubbles (MBs) increases epidermal permeability and thus facilitates the transfer of drugs into deeper tissues. Objectives To investigate the efficacy of combining US-mediated MB cavitation with piroxicam gel for hand arthritis. Design A single-center…
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Artikel Jurnal
Disease-related readmission in anti-SRP-positive immune-mediated necrotizing myopathy: Incidence and exploratory associated factors in a retrospective cohort study
Background Anti-signal recognition particle (anti-SRP)-positive immune-mediated necrotizing myopathy (IMNM) is a severe subtype of idiopathic inflammatory myopathy, but its long-term prognosis and determinants of adverse outcomes remain insufficiently defined. Because relapse is difficult to…
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Artikel Jurnal
Early identification of difficult-to-manage axial spondyloarthritis using machine-learning decision trees
Background: Axial spondyloarthritis (axSpA) is an inflammatory disease in which, despite expanding therapeutic options, a substantial proportion of patients do not achieve the desired treatment target, highlighting the emerging concept of difficult-to-manage (D2M) axSpA. Objectives: To identify…
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Artikel Jurnal
Precision imaging biomarkers for gout: artifact-specific spectral CT parameters for personalized differentiation of tophi in a prospective study
Background: Spectral computed tomography (CT) enables non-invasive visualization and quantification of monosodium urate deposits and has an important role in gout diagnosis and monitoring. However, artifact-related false-positive findings may reduce diagnostic confidence, particularly when…
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Artikel Jurnal
Development and validation of a clinical scoring system for the prediction of methotrexate treatment response in rheumatoid arthritis patients: a multicenter real-world study
Background: Methotrexate (MTX) remains the anchor drug in rheumatoid arthritis (RA) management. However, treatment response varies widely. Objectives: This study aimed to develop and validate a simple scoring model for predicting MTX monotherapy treatment success at 6 months. Methods: We conducted…
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Artikel Jurnal
Patients with poorer health status are more likely to have difficult-to-manage axial spondyloarthritis: insights from a real-world cohort
Background: Predicting difficult-to-manage (D2M) axSpA remains challenging, as both inflammatory and non-inflammatory factors contribute to treatment failure. Functional impairment captured by Health Assessment Questionnaire–Disability Index (HAQ-DI) and Multidimensional Health Assessment…
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Artikel Jurnal
Towards an individualised approach to pain management in inflammatory arthritis
Pain management in inflammatory arthritis (IA) remains challenging. The contribution of multiple mechanistic factors to the initiation and maintenance of pain, and the interplay of sensory, psychological and social factors that modulate perceptual outcomes, requires a multi-faceted approach that…
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Artikel Jurnal
Central sensitization in psoriatic arthritis: prevalence, clinical correlates, and association with therapeutic refractoriness in an unselected cohort excluding fibromyalgia
Background: Central sensitization (CS) contributes to persistent pain in psoriatic arthritis (PsA), yet its prevalence, independent predictors, and association with therapeutic refractoriness remain incompletely characterized across disease phenotypes. Objectives: To evaluate CS prevalence and…
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Artikel Jurnal
Incidence of interstitial lung disease in seropositive rheumatoid arthritis patients receiving biologics, Janus kinase inhibitors, or methotrexate
Background: The relationship between biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) and the incidence of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) remains unclear. Objective: To investigate the influence of b/tsDMARDs on the…
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Artikel Jurnal
Serum IgG N-glycosylation profiles distinguish primary Sjögren’s disease, rheumatoid arthritis, and systemic lupus erythematosus and are associated with disease activity in Sjögren’s disease
Background IgG N-glycosylation regulates immune effector functions and inflammation, but disease-specific patterns in primary Sjögren’s disease (SjD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are insufficiently defined, particularly in SjD. Objectives To identify serum IgG…
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Artikel Jurnal
Bridging with a single glucocorticoid injection in psoriatic arthritis: Real-world evidence of short-term effectiveness, safety, and enhanced response in high-inflammatory burden patients
Background The use of adjunctive systemic glucocorticoids (GC) as bridging therapy in psoriatic arthritis (PsA) remains controversial due to limited disease-specific evidence and safety concerns. Although clinical experience suggests potential benefits in selected patients, clear criteria for…
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Artikel Jurnal
Predictors of intramuscular glucocorticoid bridge therapy failure in rheumatoid arthritis: a real-world observational study
Background: Intramuscular glucocorticoid (GCs) bridge therapy is an equivalently recommended bridging strategy to oral GCs for rheumatoid arthritis (RA) under predefined tapering and discontinuation schemes. Objectives: We aimed to investigate the risk factors of intramuscular GCs bridge therapy…
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Artikel Jurnal
Towards a consensus definition of “refractory osteoarthritis”. A systematic review
Background Osteoarthritis is a highly prevalent and debilitating joint disease. Some patients continue to experience substantial symptoms despite recommended, well-conducted treatment, but the absence of a widely accepted definition of “refractory OA” complicates their identification and…
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Artikel Jurnal
More is less: Glucocorticoid-sparing agents in polymyalgia rheumatica
Polymyalgia rheumatica (PMR) is one of the most common inflammatory rheumatic diseases in older adults. Glucocorticoids (GC) are very effective in treating PMR, but their use is associated with adverse events such as infections, osteoporosis or ophthalmological diseases. In patients with relapsing…