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Mobile DNA
Scopus
ISSN 1759-8753 · BMC · 394 artikel di indeks
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Artikel Jurnal
Expression of endogenous retroviral elements is associated with extracellular matrix remodeling in prostate cancer
Abstract How endogenous retroviral elements (ERVs), a family of transposable elements, may promote tumor progression is not well understood. Tripartite motif-containing 28 (TRIM28/TIF1b/KAP1) is a key transcriptional co-repressor protein that represses ERV expression in many cell types including…
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Artikel Jurnal
Acute testicular hyperthermia leads to rapid loss of global piRNA and a concurrent increase in LINE1 activity within heat sensitive male germ cells
Abstract Background Spermatogenesis is a highly temperature sensitive process, which occurs 2–6 °C below core body temperature. Testicular hyperthermia rapidly affects male precursor cells, including spermatocytes and round spermatids, leading to elevated DNA damage. To understand the immediate…
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Artikel Jurnal
Tracing ancient viral footprints: a comprehensive study of endogenous viral elements in Bombus species
Abstract Background Endogenous Viral Elements (EVEs) are viral sequences integrated into the host germline and passed to offspring. Most virus types can integrate, often with the help of host retroelements, especially for non-retroviral RNA viruses. It is known that EVEs are widespread across…
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Artikel Jurnal
Unifying Repbase and Dfam: a new open foundation for transposable element research
Abstract Repbase and Dfam, the two foundational resources for transposable element annotation, are being unified into a single, fully open access framework, with Repbase released under CC-0 and its core curation team joining the Dfam project.
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Artikel Jurnal
HERV-K HML-2 transcriptional profiling and splicing pattern unveiled by direct single-molecule long-read RNA sequencing
Abstract Background The evolution of human genome has been inextricably linked to germ cell infectivity and retrotransposition activity of endogenous retroviruses (ERVs). In result, 8% of the modern human DNA is occupied by human ERVs (HERVs), which although non-infectious and replication…
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Artikel Jurnal
Howler monkey Platy-1 and Alu SINEs: a resource for Alouatta genomics
Abstract Recent discovery of two lineage-specific Platy-1 SINE (Short INterspersed Element) subfamilies, active within the genome of mantled howler monkey (Alouatta palliata) [AloPal_v1], prompted analyses by polymerase chain reaction (PCR) to evaluate their utility for population genetics. A…
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Artikel Jurnal
Hide and seek: de novo identification in sugar beet reveals impact of non-autonomous LTR retrotransposons
Abstract Plant genomes are filled with retrotransposons and their derivatives, constantly undergoing sequence diversification and structural rearrangement. Among them, short, non-autonomous retrotransposons lack full coding capacity and often form subfamilies. As a result, non-autonomous…
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Artikel Jurnal
Transposable element dynamics and regulatory role in sika deer (Cervus nippon) antler development
Abstract Background Deer antlers represent one of the few mammalian organs capable of complete regeneration, yet the underlying genomic regulatory mechanisms remain incompletely understood. Transposable elements (TEs), as key drivers of genome evolution and gene regulation, may play pivotal roles…
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Artikel Jurnal
G lomhopper—a subfamily of DUF3504-encoding CryptonA elements in Glomeromycota
Abstract Background Transposable elements drive genomic changes and are mobilized by specific nucleases. Among them are tyrosine recombinases (YRs), which mediate DNA cleavage and rejoining. YR-encoding elements, such as DIRS, Ngaro, Crypton, and Starships, occur in diverse eukaryotes and display…
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Artikel Jurnal
Dynamic transposable element expression during Hydra head regeneration
Abstract Transposable elements (TEs) contribute to genome expansions, gene duplications, and the evolution of gene regulatory networks. Recent work has highlighted the role of TE domestication in contributing to regulatory programs during animal development. Likewise, a role for TEs in regeneration…
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Artikel Jurnal
Stones in genomic storms: transposable element-driven variation in Prunus fruit trees
Abstract Transposable elements (TEs) are major components of plant genomes and drivers of structural and functional diversification. In Prunus species, including peach, almond, apricot, cherry, and plum, TEs constitute more than half of the genome and shape evolutionary trajectories and phenotypic…
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Artikel Jurnal
Transposable elements in hematopoietic stem cells upon aging and myeloid malignancies
Abstract Transposable elements (TEs) constitute nearly half of the human genome and profoundly influence hematopoietic stem cell (HSC) biology. In this review, we synthesize current evidence demonstrating that TEs exert dual and context-dependent roles in HSCs during steady-state hematopoiesis…
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Artikel Jurnal
Transposable elements in the era of data science EMBO course: a call for open, accessible, and collaborative TE resources
Abstract This community letter represents a collective outcome from the EMBO Practical Course “Transposable Elements in the Era of Data Science” held at the Rosalind Franklin Institute from 12 to 16 May 2025, Didcot, United Kingdom ( https://meetings.embo.org/event/25-transposable-elements )…
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Artikel Jurnal
Boundary-associated propagation of a processed pseudogene dissects pre-existing limitations of genome annotation in the T2T era
Abstract Background Processed pseudogenes and retrogenes are defined by their RNA-mediated origin and, by virtue of this origin-based definition, are often interpreted as discrete genomic insertions. The completion of telomere-to-telomere (T2T) reference assemblies has substantially improved the…
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Artikel Jurnal
scTELL: a single-cell ATAC-seq tool for locus-specific transposable element identification in chromatin accessibility
Abstract Background Transposable elements (TEs) constitute a substantial fraction of the human genome and contribute to gene regulatory programs. However, systematic analysis of TEs at the individual locus level remains technically challenging, particularly in single-cell contexts. While…
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Artikel Jurnal
Massive proliferation of retrotransposons contributes to genome size expansion in species of the Pseudocercospora genus
Abstract Genome size expansions are common among eukaryotic lineages. Enlarged genomes can be bioenergetically demanding, and active mobile elements can trigger chromosomal rearrangements and loss of gene function. What triggers genome size expansions remains largely unexplored in many biological…
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Artikel Jurnal
The extraordinary satellitome diversity of freshwater crayfish: a driver of genome evolution
Abstract Background Repetitive elements, particularly satellite DNA (satDNA), play a significant role in genome evolution and organisation. However, their diversity and evolutionary dynamics remain poorly understood in non-model organisms. Freshwater crayfish (Decapoda, Astacidea) have large…
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Artikel Jurnal
A phylogenetic estimate of canine retrotransposition rates based on genome assembly comparisons
Abstract Background Due to their history of domestication and breed formation, dogs are a powerful system for studying the phenotypic impact of genetic variation. Comparison of canine genome assemblies show that retrotransposons, mobile elements that mobilize via an RNA intermediate, are a major…