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Ķazaķstannyṇ Klinikalyķ Medicinasy
Scopus
ISSN 1812-2892 · National Scientific Medical Center · 718 artikel di indeks
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Artikel Jurnal Teks lengkap
Association of Vaginal Microbiota Composition with Human Papillomavirus Persistence in Cervical Dysplasia and Cervical Cancer: a Systematic Review and Meta-Analysis
Introduction: Persistent high-risk human papillomavirus (hrHPV) infection is the main step in cervical carcinogenesis. The vaginal microbiota may modulate this risk, but the evidence is heterogeneous. This is because previous reviews have not provided a quantitative synthesis that specifically…
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Addressing Underdiagnosis of Chronic Kidney Disease in Kazakhstan: a Public Health Perspective
Chronic kidney disease represents a growing public health challenge in Kazakhstan, yet a substantial proportion of cases remain undiagnosed. National registry data suggest lower recorded prevalence compared with global estimates, while local epidemiological studies indicate that many individuals…
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Effects of Vagus Nerve Stimulation on Upper-Limb Motor Function After Stroke: A Systematic Review and Meta-Analysis of RCTs
Background. Stroke results in persistent upper-limb motor impairment, and survivors experience incomplete recovery despite standard rehabilitation. Vagus nerve stimulation (VNS) has emerged as a potential neuromodulatory adjunct capable of enhancing training-dependent plasticity. This meta-analysis…
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Kazakh-Language Adaptation of the Work-Related Musculoskeletal Disorders Questionnaire: A Pilot Study
Objective. To translate, culturally adapt, and validate the Work-Related Musculoskeletal Disorders Questionnaire (WMSDsQ) into the Kazakh language among nursing professionals, and to assess its psychometric properties to support its use in further research and clinical practice for the evaluation…
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The Methylation Connection: Impact of MTHFR C677T and A1298C Variants on Homocysteine, Folate, and B12 Profiles in Adolescent Cardiovascular Health
Background: Coronary heart disease (CHD) is a leading cause of death in South Asia. Genetic and metabolic factors play a significant role in the burden of CHD. Although associations between homocysteine, MTHFR polymorphisms, and CHD have been previously reported, the synergistic interaction of…
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Investigating the Relationship between COVID-19 Vaccination and ACE2 Gene Expression in Cardiovascular Disease
Background: Cardiovascular disease (CVD) is a major global health problem, and the angiotensin-converting enzyme 2 (ACE 2) gene plays a crucial role in SARS-CoV-2 cell entry and cardiovascular homeostasis. Although COVID-19 vaccines are widely used, their potential effects on ACE2 gene expression…
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Cross-Modal Self-Attention Fusion for Breast Cancer Subtype Classification Using Multi-Omics Data
Background: Accurate classification of breast cancer subtypes is essential for personalized therapy and prognosis. Traditional subtype classification basically relies on gene expression profiling, usually overlooking other genomic signals like copy-number alterations (CNA) and mutations. At the…
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Impact of Microablative Fractional CO₂ Laser Applied in Menopausal Period on Vulvovaginal Atrophy and Dyspareunia: A Systematic Review and Meta-analysis Study
Aim: This study aimed to synthesize current evidence on the clinical effectiveness of microablative fractional CO₂ laser (MFCO₂) therapy for the management of menopausal vulvovaginal atrophy and dyspareunia. Methods: A meta-analysis was conducted to identify relevant studies published within the…
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Prediction of Paroxysmal Atrial Fibrillation in Patients with Sinus Rhythm
Objective: To create a tool for the prediction of paroxysmal atrial fibrillation (PAF) in patients with sinus rhythm. Methods: Single-center, case-control study. None of the patients had a prior diagnosis of AF or reported symptoms of heart arrhythmias. Among the cohort of 6,630 individuals…
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Identification of Hub Genes Associated with Bile Duct Cancer Using Integrated Gene Expression Data with Protein-Protein Interaction Network
Introduction: Bile duct cancer (cholangiocarcinoma) is an uncommon but highly aggressive malignancy characterized by late diagnosis and poor prognosis. Molecular profiling is essential to understand its pathogenesis and identify biomarkers for early detection and targeted therapy. This study aimed…
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3-Three Year BAROS Score Outcomes for One anastomosis Gastric Bypass and FundoRing One anastomosis Gastric Bypass
Objective: To compare the 3-year quality of life, weight loss, comorbidity remission, and complication rates between FundoRing One-Anastomosis Gastric Bypass (f-OAGB) and standard OAGB (s-OAGB) in patients with obesity. Background: While OAGB is an effective metabolic procedure, it is associated…
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Study of Serum microRNA-217 Expression Pattern in Different Stages of Diabetic Kidney Disease – a Cross-sectional Study
Background: Diabetic kidney disease (DKD) represents the leading cause of end-stage renal disease worldwide, affecting 30-40% of patients with type 2 diabetes mellitus (T2DM). Some microRNAs (miRNAs), like miRNA-217 are upregulated in Diabetic Kidney Disease (DKD), and known to play a key role in…
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Impact of Nanocellulose-Based Biocomposite Implantation on Rodent Behavior in the Elevated Plus Maze Test
Introduction: For application in regenerative medication, the biomaterial used in implants should have both structural and biological compatibility along with long-term safety with respect to the central nervous system. Nanocellulose (NC) is a promising biomaterial when it comes to…
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Structural and Cognitive Measures Across Childhood, Adolescence, and Adulthood: Associations with Education and Brain Morphometry
Background: The organization of the human brain shows key characteristics through its cortical thickness and brain volume distribution across different regions, and the way both brain hemispheres display their distinct functions. However, age-stratified neuroimaging data that jointly consider…
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The Stroop Test as a Tool for Assessing Cognitive Dysfunction in Patients with Metabolic Syndrome
Abstract Objective: The aim of the study was to evaluate cognitive functions in patients with metabolic syndrome with clinical and metabolic indicators using the Stroop test. Introduction: Metabolic syndrome is a complex of disorders that includes abdominal obesity, insulin resistance, lipid…
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The Effect of Postmenopausal Therapeutic Interventions on Sexual Function: a Meta-analysis Study
Aim: The purpose of this study is to identify how therapeutic interventions after menopause affect sexual function. Methods: For this study, research was conducted by screening studies in PubMed, Web of Science, EBSCOhost, Google Scholar, and YOK Thesis Center databases from May to July 2024. After…
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Bioinformatics Analysis Identifying Key Genes and Signaling Pathways Involved in the Egg Allergy in Young Children: a Retrospective Study
Objective. Identify key genes and signaling pathways involved in IgE-mediated food allergy in young children using bioinformatics analysis. Materials and Methods. The GSE114065 dataset from GEO was utilized for bioinformatic analysis. DEGs were identified using the GEO2R web tool. GO, KEGG, and…
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Multi-Biomarker Stratification of Coronary Artery Disease in Diabetic and Non-Diabetic Patients: Adiponectin, Inflammation, and Insulin Resistance
ABSTRACT Background: Coronary artery disease [CAD] remains a leading cause of global mortality, with higher prevalence among individuals with type 2 diabetes mellitus [T2DM]. Limited data exist on biomarker interactions in CAD patients with and without T2DM. Objective: This study aimed to…
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Cytogenetic Characteristics and Treatment Outcomes of Congenital Acute Leukemia in Children in Kazakhstan: Retrospective Study
Background: Congenital acute leukemia (CAL) is a rare and aggressive hematologic malignancy diagnosed within the first 28 days of life. Cytogenetic abnormalities are essential for risk stratification and prognosis, but data on CAL in Kazakhstan remain limited. Objective: To describe cytogenetic…
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Determination of Body Mass Index Using Machine Learning Regression Methods from Body Composition Parameters
Introducton: Obesity is one of the most significant global health problems increasing today. Body mass index (BMI) is a fundamental parameter widely used to assess obesity. However, evaluating different measurements of body composition may contribute to determining BMI more accurately and…