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Al-Mustansiriyah Journal of Pharmaceutical Sciences
ISSN 1815-0993 · College of Pharmacy / Mustansiriyah University · 704 artikel di indeks
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Artikel Jurnal
Disability Status and Quality of Life in Iraqi Patients with Multiple Sclerosis; an Observational Study
Background: Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system and a major non-traumatic disabling in young adults. Disability adversely affects quality of life, daily activities, and psychological abilities, reducing independence. Therefore, evaluating…
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Correlation between Diabetic Control and Visual Outcomes of Aflibercept versus Bevacizumab Therapy in Iraqi Patients with Diabetic Macular Edema
Background: Diabetic retinopathy represents a significant burden on the public healthcare system in Iraq. While anti-vascular endothelial growth factor (anti-VEGF) agents have revolutionized management. However, a limited number of studies on the effectiveness of these agents and their comparison…
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Assessment of the Diagnostic Potential of Lecithin-Cholesterol Acyltransferase in Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic liver disorder characterized by fat accumulation in hepatocytes. Lecithin-cholesterol acyltransferase (LCAT) is a liver-derived enzyme involved in lipid metabolism and may serve as a biomarker of hepatic metabolic function. The…
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Artikel Jurnal
Prevalence of Cardiac Remodeling among Non-Dialysis Dependent Chronic Kidney Disease Outpatients in a Sample of the Iraqi Population: A Preliminary Study
Background: Pressure overload, uremic toxins, and deteriorating renal function are the main causes of ventricular hypertrophy in chronic kidney disease, which increases with the severity of the condition. Aims: The study aims to investigate the types and prevalence of cardiac remodeling among…
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Artikel Jurnal
Ameliorative role of Omega-3 fatty acids and Vitamin E against Carbamazepine induced Hepatoxicity in Rats
Background: Carbamazepine has been utilized to treat epilepsy and neuralgic conditions. Drug-induced liver injury triggered by Carbamazepine. Drug-induced liver injury from Carbamazepine consequently leads to liver failure. Existing research found that Omega-3 fatty acids and vitamin E known for…
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Pharmacological Activities of Ribwort Plantain and its Key Constituents: a Review
Ribwort plantain has shown considerable pharmacological properties that are related to its wide-range secondary metabolites. The present review is aimed to highlight the recent progress on the antimicrobial, anti-inflammatory, antioxidant, neuroprotective, anticancer and wound healing effects of…
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Influence of medication related burden on asthma control and medication adherence among Iraqi asthmatic patients
Background: Medication-related burden (MRB) reflects negative patient experiences with treatment, including adverse effects, concerns about dependency, and the complexity of different regimens. Asthmatic patients are subjected to multiple inhalers and oral drugs that can heighten the MRB, reduce…
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Artikel Jurnal
Antimicrobial treatment pattern and Medications Adherence among Iraqi T2DM patients with recurrent urinary tract infection in Wasit province
Background: Recurrent urinary tract infections (rUTIs) are common in type 2 diabetes mellitus (T2DM) patients due to impaired immunity, glycosuria, and chronic comorbidities. Antimicrobial resistance complicates therapy, and inappropriate use further worsens recurrence. Objective: To evaluate…
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The effect of Mangosteen on Inflammation, Oxidative Status, and Hepatorenal Function in Patients with Type 2 Diabetes Mellitus
Background: Oxidative stress (OS) and inflammation are significant factors in the etiology of type 2 diabetes mellitus (T2DM). Mangosteen (MG) possesses anti-inflammatory and antioxidant activities due to its high concentrations of xanthones, particularly (α-MG) and (γ-MG). Objectives: This study…
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Artikel Jurnal
Resveratrol Enhances Gemcitabine-Induced Apoptosis in A549 Non-Small Cell Lung Cancer Cells
Background: Lung cancer is the commonest cause of cancer related mortality. Non-small cell lung cancer (NSCLC) is the most prevalent kind of lung malignancies. Gemcitabine is a first line drug used in NSCLC. However, the therapeutic efficacy of gemcitabine is constrained by the drug resistance and…
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Comparative Study of Hydrophilic Polymer-Based Solid Dispersions of Griseofulvin Incorporating HPMC E6, PVP K30, and Soluplus
Solid dispersion approach with hydrophilic carriers is one of the most effective methods for improving the solubility, dissolution profile, and ultimately the oral bioavailability of poorly water-soluble drugs. In this study, Griseofulvin (GF), a BCS class II drug with poor solubility and a strong…
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In Silico Evaluation of Benzimidazole-Derived Heterocycles as CYP51-Targeting Antifungal Agent: Molecular Docking, Dynamics, and ADME Analysis
To counter the rising clinical threat of azole-resistant strains of Candida albicans, here, the design and computational validation of new benzimidazole-based heterocycles designed to inhibit the enzyme CYP51 is investigated. Employing a combination of GOLD-dependent molecular docking and…
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Design, Molecular Docking, and Pharmacokinetic Evaluation of Naproxen-Based 2‑Azetidinone Derivatives for Cancer Treatment
This study investigates the design, molecular docking, and ADME properties of six novel naproxen derivatives featuring a 2-azetidinone ring, targeting EGFR kinase. Molecular docking was conducted using the crystal structure of the EGFR mutant complexed with Osimertinib (PDB ID: 6LUD). The…
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Artikel Jurnal
Antioxidant, anti-inflammatory, and neuroprotective role of pterostilbene in attenuating Alzheimer-like pathology in AlCl3-induced rats’ model of Alzheimer's disease
Background: Alzheimer’s disease (AD) is a degenerative neurological ailment marked by the accumulation of aberrant protein deposits in the brain, including beta-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) formed from tau protein. Objectives: to evaluate the potential preventive effects…
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Artikel Jurnal
The Diagnostic Potential of Glial Fibrillary Acidic Protein (GFAP) in Acute Stroke Patients
Background: Ischaemic stroke (IS) and hemorrhagic stroke (HS) are considered second leading cause of death and causing great disability. Neuroimaging techniques are primarily used to differentiate between them, however they are not available in all centers and can not be used in some patient Aim…
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Artikel Jurnal
Evaluation of The Antioxidant, Hypolipidemic, and Pancreatic Histological Alterations Effects of Tirzepatide in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Rats
Background: Type 2 diabetes mellitus (T2DM) is a complicated and multifaceted metabolic disease defined by insulin resistance, dyslipidemia, oxidative stress, and β-cell dysfunction. Tirzepatide (TZP), a dual GIP and GLP-1 receptor agonist, offers potent glucose-lowering and weight-loss. Objective…
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Artikel Jurnal
High-Dose of oral Montelukast Induces Monoamines Depletion and brain-Derived Neurotrophic Factor BDNF Upregulation in male Rat's Brain
Background: Montelukast, a leukotriene D4 antagonist used for asthma and allergic rhinitis, has been increasingly linked to neuropsychiatric effects, including mood disorders and suicidality. Its impact on central monoamine neurotransmitters and neurotrophic factors remains unclear. Objective: This…
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Artikel Jurnal
Liraglutide Ameliorates Metabolic Dysfunction Targeting the NRF2 Pathway in Obese Rats Induced by a High-Fat Diet
Background: Obesity, driven largely by high-fat diets, is strongly linked to insulin resistance, dyslipidemia, and oxidative stress. The nuclear factor erythroid 2-related factor 2 (NRF2) pathway is very important for keeping the redox balance in cells and guarding against liver damage caused by…
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Artikel Jurnal
In-silico Prediction of Binding Affinities and Pharmacokinetic Parameters of Indoline-2-one Derivatives as Anticancer HDAC Inhibitors
The present work explores the molecular docking and pharmacokinetic features of indoline-2-one derivatives as potential anticancer agents by targeting histone deacetylase enzyme (HDAC1) which is the crucial element in tumor progression. Docking studies on the derivatives were performed based on…
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Artikel Jurnal
Association of Helicobacter pylori Infection with Clinical Characteristics and Steroid Response in Patients with Immune Thrombocytopenia: An Observational Study
Background: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by reduced platelet counts. Helicobacter pylori infection has been implicated in ITP pathogenesis, though its effect on clinical features and initial treatment response remains unclear. Objective: To assess the impact…