871 results
Showing 1–20 · 0.20 seconds · RSS
Asian Journal of Pharmaceutical Sciences
Scopus
ISSN 1818-0876 · KeAi Communications Co., Ltd. · 871 articles in the index
-
Journal Article
Injectable dual-affinity self-assembling peptide hydrogels for local controlled delivery of therapeutic antibodies
Therapeutic monoclonal antibodies have revolutionized the treatment of cancers, infectious diseases and immune disorders; however, their efficacy is compromised by limitations associated with systemic administration, including systemic toxicity, poor patient compliance and inadequate drug…
-
Journal Article
A drug-repurposing nanotheranostic for synergistic management of resistant bacterial pneumonia
The rising threat of antibiotic resistance severely compromises the treatment of bacterial pneumonia, underscoring the urgent need for innovative and comprehensive therapeutic strategies. Here, we developed an innovative theranostic nanoplatform (Dex/BTGd) through the coordinated assembly of…
-
Journal Article
Engineered GLUT1-targeted STING polyproagonists: Redox-triggered activation and enhanced endosomal escape for cancer immunotherapy
The stimulator of interferon genes (STING) pathway plays a critical role in bridging innate and adaptive antitumor immunity, representing a promising target in cancer immunotherapy. However, the clinical application of STING agonists is limited by poor pharmacokinetics, low cytosolic delivery…
-
Journal Article
Bioactive hydrogels for bone tissue engineering: Design strategies, bioactive cargo delivery, and artificial intelligence–assisted clinical translation
The functional reconstruction of bone defects caused by trauma, infection, surgical resection and degenerative diseases poses substantial clinical challenges. Bone tissue engineering (BTE) holds immense potential for treating bone defects while avoiding complications commonly associated with…
-
Journal Article
Oral probiotic delivery-based therapeutic strategies for inflammatory bowel disease
Over the past decade, accumulating evidence supporting the efficacy of probiotics in gut microbiota modulation has spurred interest in their therapeutic potential for inflammatory bowel disease (IBD), a chronic intestinal disorder for which safer and more sustainable alternatives to conventional…
-
Journal Article
Janus microneedles enabling orderly vitiligo treatment through spatiotemporal sequential promoting melanogenesis to transfer via PAR2 activation
Vitiligo is characterized by a complex pathogenesis involving multiple factors, necessitating therapeutic strategies that simultaneously achieve immune regulation, melanocyte regeneration, and melanosome transfer modulation. Here, we designed a Janus microneedle (Janus MN) based on a core-shell…
-
Journal Article
Hydrogel co-delivery of 5-fluorouracil and siRNA attenuates TGF-β1-mediated MMT to prevent postoperative peritoneal metastasis and adhesion in colorectal cancer
Cytoreductive surgery is the treatment protocol for colorectal cancer. Nonetheless, a major medical challenge remains to fully eliminate malignant tumor cells, along with a number of complications such as peritoneal adhesion and tumor peritoneal metastasis. The occurrence of peritoneal adhesions…
-
Journal Article
Carrier-free doxorubicin nanomedicine integrates chemotherapy and chemodynamic therapy to achieve anti-tumor efficacy
Nanomedicines have been constructed to enhance the efficacy and safety of traditional anti-cancer drugs. However, the clinical translation of these nanomedicines was hindered by the complexity of carrier materials and functional integration. In this study, a carrier-free nanomedicine composed of…
-
Journal Article
Melatonin-inspired hybrid spheroids accelerate intestinal repair via YAP-driven fetal reprogramming
Following injury, prostaglandin E2 (PGE2) drives intestinal epithelial repair by inducing revival stem cells (RSCs), which compensate for the loss of homeostatic Lgr5+ stem cells. Using intestinal organoid models, we demonstrate that melatonin potentiates the PGE2- or damage-induced RSC emergence…
-
Journal Article
A barrier-crossing and immune checkpoint-blocking antibody fusion protein for enhanced glioma-targeted immunotherapy
With low five-year survival estimates, poor prognosis, and high recurrence probabilities, glioma is considered one of the most intractable malignant tumors. Despite the discovery of lymphatic vascular system and immune system in the central nervous system (CNS), immune checkpoint blockade…
-
Journal Article
Carrier-free reduction-responsive self-assembling paclitaxel dimer nanoprodrug synergizing with celastrol for enhanced chemoimmunotherapy
Chemotherapeutic paclitaxel (PTX) formulations are widely used in clinical cancer treatment; however, they are also associated with concomitant programmed death-ligand (PD-L1) upregulation and an immunosuppressive microenvironment. Herein, we rationally designed carrier-free, reduction-sensitive…
-
Journal Article
Inhalable stem cell-derived artificial nanovesicles for targeted siRNA delivery to effectively alleviate asthma symptoms
Asthma, one of the most prevalent chronic inflammatory diseases, remains challenging to manage effectively. Current therapies commonly alleviate symptoms through broad immunosuppression and bronchodilation but fail to target disease-specific molecular pathways. Genetic intervention using small…
-
Journal Article
Dual-functional self-assembled nanosystems with enhanced protease resistance: Promoting bacterial aggregation and immune activation for multidrug-resistant bacterial infection
Multidrug-resistant bacterial infections are increasing globally and posing a greater threat to human health. The application of direct bactericidal agents can induce secondary infections and treatment failures. The antibacterial strategy of the innate immune system brings inspiration. Here, we…
-
Journal Article
Controlled release of berberine modulates the wound microbiome to accelerate wound healing
The wound microbiome has been shown to play a significant role in influencing the wound healing process. Coptis chinensis, a traditional Chinese medicine (TCM) known for its heat-clearing properties, contains berberine (BER) as major active ingredient, which exhibits notable antibacterial activity…
-
Journal Article
A programmable nanoreactor for photothermal immunotherapy via NIR-II triggered enzyme-catalyzed immunogenic tumor microenvironment remodeling
The complicated and immunosuppressive tumor microenvironment usually obstruct the efficiencies of various therapeutic schedules including immunotherapy. Here, we report a programmable polymer-based nanoreactor for photothermal-enhanced immunotherapy through second near-infrared (NIR-II)…
-
Journal Article
Nose-to-brain delivery of donepezil within a small dose improves bioavailability and efficacy for Alzheimer’s disease treatment
Oral administration of donepezil (Don) is the first-line medication for Alzheimer’s disease (AD); however, the dysphagia of elderly patients and severe gastrointestinal side effects substantially restrict administration compliance. Herein, we exploit a nose-to-brain pathway for Don administration…
-
Journal Article
Advances in molecular glue degraders for targeted protein degradation: Focus on NEK7, WEE1, CDK2, GSPT1 and VAV1
Molecular glues (MGs), a class of small-molecule degraders, exhibit drug-like properties that generally conform to Lipinski's rule of five, while uniquely mediating the stabilization or induction of protein-protein interactions. By altering the surface properties of either target proteins or E3…
-
Journal Article
Advances in nanotechnology for the diagnosis and management of autoimmune diseases
Autoimmune diseases (AIDs) are chronic, heterogeneous disorders that are often diagnosed after irreversible tissue damage and treated with broad immunosuppression that fails to deliver durable remission. Nanotechnology offers opportunities to sense early immune perturbations and to deliver…
-
Journal Article
ACQ-FRET dual-functional near-infrared fluorescent probes for the bioimaging of nanocarriers
Förster resonance energy transfer (FRET) and aggregation-caused quenching (ACQ) are well-established mechanisms with promising potential to eliminate interference from free probes in studies of in vivo nanocarrier behavior. However, both approaches have a critical limitation, fluorescence…