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Klinicist
Scopus
ISSN 1818-8338 · ABV-press · 603 articles in the index
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Journal Article
Pathogenetic features of pulmonary hypertension in systemic sclerosis
Systemic connective tissue diseases may be associated with various forms of pulmonary hypertension (PH). The prevalence of PH varies among different systemic connective tissue diseases, with systemic scleroderma (SSc) having the highest rate, ranging from 8 to 12 %. With SSc, PH is one of the…
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Journal Article
Osteoarthritis associated with metabolic syndrome: epidemiology, pathogenesis, treatment
Metabolic syndrome (MS) is a complex of metabolic disorders, including insulin resistance, abdominal obesity, diabetes mellitus, hyperuricemia and arterial hypertension. According to the World Health Organization, the number of people with obesity worldwide is steadily increasing, taking on the…
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Journal Article
Difficult-to-treat rheumatoid arthritis: predictors and prevention possibilities (analysis of the Moscow unified register of arthritis data)
Aim. To search for factors associated with the occurrence of a difficult-to-treat state, reflecting the characteristics of both the patient and his disease, as well as preceding treatment. Materials and methods. The analysis includes data of patients with rheumatoid arthritis (RA) from the Moscow…
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Journal Article
Bradyarrhythmias in patients with obstructive sleep apnea
Aim. To compare patients with bradyarrhythmias and obstructive sleep apnea (OSA) and patients without OSA; to study the predictive capabilities of questionnaires in OSA screening.Material and methods. The study included 134 patients with bradyarrhythmias hospitalized for pacemaker implantation or…
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Journal Article
Early osteoarthritis – current state of the art
Osteoarthritis (OA) is increasingly recognized as a complex degenerative joint disease that develops under the influence of mechanical, biochemical and genetic factors. The pathogenesis of OA includes a complex of interactions at both cellular and molecular levels, leading to progressive damage to…
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Journal Article
Prevalence of metabolically associated steatotic liver disease in the elderly: analysis and perspectives
Metabolically associated steatotic liver disease (MASLD) is becoming a major public health problem, especially among the elderly. The recent change in nomenclature from “nonalcoholic fatty liver disease” to “MASLD” reflects a more accurate understanding of the pathogenesis of the disease, linking…
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Journal Article
Clinical case and features of progression of dermatomyositis with anti-Mi2 antibodies
Aim. To present a clinical case and describe the features of dermatomyositis (DM) with myositis-specific anti-Mi2 antibodies (MSAs).Material and methods. Clinical manifestations, abnormalities of laboratory and immunologic tests, strategy and efficacy of pharmacotherapy in a patient with DM are…
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Journal Article
Mental disorders in patients with cystic fibrosis
Introduction. Cystic fibrosis (CF) is a genetic disease that leads to dysfunction of internal organs and significantly increases the risk of respiratory infections. According to the N. P. Bochkov Medical and Genetic Research Center, 1 out of 9,000 newborns suffers from CF. Chronic disease has a…
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Journal Article
Therapeutic potential of interleukin 6 inhibitors in difficult-to-treat patients with rheumatoid arthritis (results of a retrospective study)
Aim. To investigate predictors of achieving low disease activity (LDA) in patients with difficult-to-treat (DtT) rheumatoid arthritis (RA) and to assess the role of interleukin 6 (IL-6) inhibitors in reaching the target disease activity in this patient population.Material and methods. Analysis of…
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Journal Article
Use of neuroprotective therapy in nontraumatic intracranial hemorrhage: results of open-label randomized trial
Aim. To investigate the effectiveness and safety of Cellex® drug (active substance is polypeptides from the brain of pig embryos) in nontraumatic intracranial hemorrhage.Material and methods. The study included 116 patients with hypertensive intracranial hemorrhage aged between 30 and 80 years…
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Journal Article
A case of differential diagnosis of REM sleep behavior disorder and sleep-related hypermotor epilepsy
Aim. To describe a clinical case of differential diagnostics of motor phenomena during sleep. Materials and methods. Patient B., 37 years old. Visit to a somnologist at the University Clinic. Complaints were mainly made by the patient’s wife, since the patient himself does not remember these…
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Journal Article
Phenotypes of patients with asymptomatic hyperuricemia living in the Russian Federation
Aim. To identify the phenotypes of patients with asymptomatic hyperuricemia (HU) in the Russian Federation by analyzing demographic and clinical and laboratory parameters in outpatient practice.Material and methods. The data obtained in the framework of the non-interventional multicenter program…
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Journal Article
Neurodegenerative diseases and dementia: the role of blood-brain barrier dysfunction (based on recent evidence)
The review describes the molecular architecture and physiology of the blood-brain barrier (BBB), modern methods for assessing the condition of the BBB, the role of its dysfunction in some neurodegenerative diseases, and the contribution of vascular pathology. The pathogenetic mechanisms by which…
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Journal Article
Modern possibilities of echocardiographic diagnosis in pulmonary arterial hypertension
Pulmonary Hypertension (PH) is a hemodynamic and pathophysiological condition characterized by an increase in mean pulmonary artery (PA) pressure by at least 20 mm Hg at rest, measured during right heart catheterization. One of the fastest and most accessible screening non-invasive diagnostic…
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Journal Article
Visual hallucinosis in patients with Parkinson’s disease
Aim. To determine the effect of visual impairment on the formation of visual hallucinosis.Materials and methods. We studied 87 patients with Parkinson’s disease (PD). The average age of the patients was 65.16 ± 8.22 years. The patients underwent a comprehensive neurological and ophthalmological…
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Journal Article
Alcoholic cardiomyopathy: aspects of pathogenesis and clinic
Alcoholic cardiomyopathy is the most common form of myocardial damage caused by ethanol. Ethanol and its main active metabolite acetaldehyde have a direct toxic effect on the myocardium. The mechanisms of the cardiotoxic effect of ethanol are diverse and include membranotropic action, damage to…